Výsledky vyhledávání - "Michelle Gumz"

Adrenal-Kidney Clock Crosstalk: Utilizing Tissue-Specific Clock KO Models

Autor: Hannah Costello, G. Ryan Crislip, Annalisse Mckee, Kit-Yan Cheng, Alexandria Juffre, Jermaine Johnstone, Lauren Douma, Michelle Gumz

Publikováno v: Physiology. 38

Circadian rhythms are 24-hour oscillations that regulate many physiological functions including hormone signaling and electrolyte excretion. These rhythms are coordinated by a molecular clock, comprised of 4 key core clock proteins – BMAL1, CLOCK,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d385dca03e45b841222873cd584d535
https://doi.org/10.1152/physiol.2023.38.s1.5731958

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Differential effects of the clock protein BMAL1, diet, and sex on purinergic receptor expression in the distal nephron

Autor: Jermaine Johnston, Hannah Costello, Charles Wingo, Michelle Gumz, Gene Crislip

Publikováno v: Physiology. 38

The circadian clock protein BMAL1 is a core component of the intrinsic molecular clock mechanism that governs circadian rhythms. We use a kidney-specific Bmal1 knockout mouse model (KS-BMAL1KO) with loss of BMAL1 expression in the distal segments of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdabe2c1edeeebff77fc693ed3d38421
https://doi.org/10.1152/physiol.2023.38.s1.5734912

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Sex-specific differences in kidney clock gene expression in mice in response to a low potassium, high salt diet

Autor: Hannah Costello, Kit-Yan Cheng, Jermaine Johnstone, Alexandria Juffre, Lauren Douma, Michelle Gumz, G. Ryan Crislip

Publikováno v: Physiology. 38

Clinical studies demonstrate that women have exacerbated salt-sensitive blood pressure (BP) responses compared to men. However, most studies examining the molecular mechanisms involved in salt-sensitive hypertension focus on males. Accumulating evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::077f817c88cf69fb891937639fb40e0a
https://doi.org/10.1152/physiol.2023.38.s1.5734672

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Knockout of circadian protein Period1 (Per1) and time of day alter the renal transcriptomic profile of Dahl SS rats

Autor: Lashodya Dissanayake, Adrian Zietara, Michelle Gumz, Alexander Staruschenko

Publikováno v: Physiology. 38

Circadian rhythm in the body is regulated through a central clock in the brain signaling through molecular clocks in the peripheral tissue. PER1, CRY, CLOCK, and BMAL1 are the 4 genes regulating the mechanism of the molecular clock. It has been estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9359af331ef0be7b03e8e915f0b48a79
https://doi.org/10.1152/physiol.2023.38.s1.5730360

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