Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michelle Giehl"'
Autor:
Wiltrud Haaß, Michael Stehle, Stefanie Nittka, Michelle Giehl, Petra Schrotz-King, Alice Fabarius, Wolf-Karsten Hofmann, Wolfgang Seifarth
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42863 (2012)
Separase, an endopeptidase required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as an ane
Externí odkaz:
https://doaj.org/article/9717e87e5e1a4a74b66d1e2ec32705d1
Autor:
Alice Fabarius, Michelle Giehl, Blanka Rebacz, Alwin Krämer, Oliver Frank, Claudia Haferlach, Peter Duesberg, Rüdiger Hehlmann, Wolfgang Seifarth, Andreas Hochhaus
Publikováno v:
Haematologica, Vol 93, Iss 8 (2008)
Background Dasatinib is a multitargeted inhibitor of ABL, the SRC family, and other tyrosine kinases. We sought to evaluate the effects of this drug on cell proliferation, centrosomes, mitotic spindles, and cell cycle progression in vitro and in vivo
Externí odkaz:
https://doaj.org/article/a7e2461f7139401da39de367aa9834ba
Autor:
Alice Fabarius, Claudia Haferlach, Martin C. Müller, Philipp Erben, Tanja Lahaye, Michelle Giehl, Oliver Frank, Wolfgang Seifarth, Rüdiger Hehlmann, Andreas Hochhaus
Publikováno v:
Haematologica, Vol 92, Iss 6 (2007)
Clonal cytogenetic aberrations of the Philadelphia chromosome (Ph) positive hematopoiesis have been associated with the natural evolution of chronic myeloid leukemia (CML) to advanced disease. Clonal aberrations of Ph negative metaphases have been de
Externí odkaz:
https://doaj.org/article/a15df6e25fcb4b948289a70398988ee8
Autor:
Alice Fabarius, Peter Duesberg, Michelle Giehl, Wolfgang Seifarth, Andreas Hochhaus, Rüdiger Hehlmann
Publikováno v:
Cellular Oncology, Vol 30, Iss 6, Pp 503-504 (2008)
Externí odkaz:
https://doaj.org/article/768eb5f15ead4955a966d644238ddb98
Autor:
Andreas Hochhaus, Karl Sotlar, Sven Schneider, Georgia Metzgeroth, Hans-Peter Horny, Alexander Marx, Juliana Schwaab, Karin Hartmann, Philipp Erben, Wolf-Karsten Hofmann, Martina Teichmann, Alice Fabarius, Thomas Ernst, Mohamad Jawhar, Nicholas C.P. Cross, Michelle Giehl, Andreas Reiter, Martin Müller
Publikováno v:
Annals of Hematology. 93:81-88
The activating KIT D816V mutation plays a central role in the pathogenesis, diagnosis, and targeted treatment of systemic mastocytosis (SM). For improved and reliable identification of KIT D816V, we have developed an allele-specific quantitative real
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfb8115d5e6e0d841bbfc7947ce80ed
https://doi.org/10.1007/s00277-013-1964-1
https://doi.org/10.1007/s00277-013-1964-1
Autor:
Wolf-Karsten Hofmann, Maximillian Mossner, Daniel Nowak, Alice Fabarius, Christiane Schumann, Torsten J. Schulze, Wiltrud Haass, Henning D. Popp, Verena Nowak, Stefan Klein, Wolfgang Seifarth, Florian Nolte, Michelle Giehl
Publikováno v:
Annals of Hematology. 92:1325-1333
Centrosomes play important roles in the maintenance of genetic stability and centrosomal aberrations are a hallmark of cancer. Deregulation of centriole duplication leads to supernumerary centrosomes, sister chromatid missegregation and could result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf5bbdd40e5d828cd998c57cba9f9a3
https://doi.org/10.1007/s00277-013-1772-7
https://doi.org/10.1007/s00277-013-1772-7
Autor:
Maurice Stephan Michel, Wolf-Karsten Hofmann, Wolfgang Seifarth, Lutz Trojan, Wiltrud Haass, Michelle Giehl, Ute Gabriel, Alice Fabarius
Publikováno v:
Cancer Genetics and Cytogenetics. 203:253-262
Tobacco smoke containing numerous derived chemical carcinogens is the main risk factor for urothelial carcinoma. These carcinogens can induce DNA damage leading to chromosomal instability, which plays a fundamental role in urothelial carcinogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65299cab4df9f1637ccbc03f4b1fe5eb
https://doi.org/10.1016/j.cancergencyto.2010.07.135
https://doi.org/10.1016/j.cancergencyto.2010.07.135
Autor:
Michelle Giehl, Peter H. Duesberg, Riidiger Hehlmann, Birgit Spiess, Chun Zheng, Wolfgang Seifarth, Martin Müller, Andreas Hochhaus, Christel Weiss, Alice Fabarius, Oliver Frank
Publikováno v:
British Journal of Haematology. 138:369-373
Summary Centrosomes play fundamental roles in mitotic spindle organisation, chromosome segregation and maintenance of genetic stability. Recently, we have demonstrated that the tyrosine kinase inhibitor imatinib induces centrosome and chromosome aber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8256d17001017bba5b304c9f81aaee10
https://doi.org/10.1111/j.1365-2141.2007.06678.x
https://doi.org/10.1111/j.1365-2141.2007.06678.x
Autor:
Michelle Giehl, Andreas Hochhaus, Oliver Frank, Philipp Erben, Wolfgang Seifarth, M Hafner, Alice Fabarius, Ruediger Hehlmann, Chun Zheng
Publikováno v:
Leukemia. 21:1971-1976
Centrosomes play fundamental roles in mitotic spindle organization, chromosome segregation and maintenance of genetic stability. Recently, we have shown that centrosome aberrations occur early in chronic myeloid leukemia (CML) and are induced by imat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b43048fd0053dd5c16ae6987182c14
https://doi.org/10.1038/sj.leu.2404834
https://doi.org/10.1038/sj.leu.2404834
Autor:
Christine Leib-Mösch, Wolfgang Seifarth, Oliver Frank, Rüdiger Hehlmann, Chun Zheng, Michelle Giehl
Publikováno v:
J. Virol. 79, 10890-10901 (2005)
The detection and identification of retroviral transcripts in brain samples, cerebrospinal fluid, and plasma of individuals with recent-onset schizophrenia and schizoaffective disorders suggest that activation or upregulation of distinct human endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcabdfa753c946f4f2a477c757b93df
https://doi.org/10.1128/jvi.79.17.10890-10901.2005
https://doi.org/10.1128/jvi.79.17.10890-10901.2005