Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michelle Gek Liang Lim"'
Autor:
Mohammad Amin Honardoost, Andreas Adinatha, Florian Schmidt, Bobby Ranjan, Maryam Ghaeidamini, Nirmala Arul Rayan, Michelle Gek Liang Lim, Ignasius Joanito, Quy Xiao Xuan Lin, Deepa Rajagopalan, Shi Qi Mok, You Yi Hwang, Anis Larbi, Chiea Chuen Khor, Roger Foo, Bernhard Otto Boehm, Shyam Prabhakar
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic insulin-secreting $$\beta$$ β cells. A comprehensive immune cell phenotype evaluation in T1D
Externí odkaz:
https://doaj.org/article/c994264bbf6c46a98457293f3fbf1308
Autor:
Bobby Ranjan, Wenjie Sun, Jinyu Park, Kunal Mishra, Florian Schmidt, Ronald Xie, Fatemeh Alipour, Vipul Singhal, Ignasius Joanito, Mohammad Amin Honardoost, Jacy Mei Yun Yong, Ee Tzun Koh, Khai Pang Leong, Nirmala Arul Rayan, Michelle Gek Liang Lim, Shyam Prabhakar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cell-type-specific genes are often strongly correlated in expression - an informative yet underexplored property of single-cell data. Here, the authors leverage gene expression correlations to develop DUBStepR, a feature selection method for accurate
Externí odkaz:
https://doaj.org/article/679d215e24a04b659dd516970921da96
Autor:
Detu Zhu, Zuxianglan Zhao, Guimei Cui, Shiehong Chang, Lingling Hu, Yi Xiang See, Michelle Gek Liang Lim, Dajiang Guo, Xin Chen, Paul Robson, Yumei Luo, Edwin Cheung
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2285-2298.e4 (2018)
Summary: Estrogen drives breast cancer (BCa) progression by directly activating estrogen receptor α (ERα). However, because of the stochastic nature of gene transcription, it is important to study the estrogen signaling pathway at the single-cell l
Externí odkaz:
https://doaj.org/article/7e4001fd3a4f4912b57120c9d96938a9
Autor:
Nirmala Arul Rayan, Vibhor Kumar, Jonathan Aow, Naghmeh Rastegar, Michelle Gek Liang Lim, Nicholas O’Toole, Edita Aliwarga, Danusa Mar Arcego, Hui Ting Grace Yeo, Jen Yi Wong, May Yin Lee, Florian Schmidt, Hajira Shreen Haja, Wai Leong Tam, Tie-Yuan Zhang, Josie Diorio, Christoph Anacker, Rene Hen, Carine Parent, Michael J Meaney, Shyam Prabhakar
Publikováno v:
Molecular Psychiatry. 27:4510-4525
Depression and anxiety are major global health burdens. Although SSRIs targeting the serotonergic system are prescribed over 200 million times annually, they have variable therapeutic efficacy and side effects, and mechanisms of action remain incompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc06ddc305fbbd950921fb8126b2e3c
https://doi.org/10.1038/s41380-022-01725-1
https://doi.org/10.1038/s41380-022-01725-1
Autor:
Vaidehi Krishnan, Florian Schmidt, Zahid Nawaz, Prasanna Nori Venkatesh, Kian Leong Lee, Xi Ren, Zhu En Chan, Mengge Yu, Meera Makheja, Nirmala Arul Rayan, Michelle Gek Liang Lim, Alice Man Sze Cheung, Sudipto Bari, Wee Joo Chng, Hein Than, John Ouyang, Owen Rackham, Tuan Zea Tan, William Ying Khee Hwang, Charles Chuah, Shyam Prabhakar, S. Tiong Ong
Publikováno v:
Blood.
Primary resistance to tyrosine kinase inhibitors (TKI) is a significant barrier to optimal outcomes in chronic myeloid leukemia, but little is known about the factors contributing to response heterogeneity. Using scRNA-sequencing, we identified eight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::922159a6483d8b64720deb739ee3f2d5
https://doi.org/10.1182/blood.2022017295
https://doi.org/10.1182/blood.2022017295
Autor:
Vaidehi Krishnan, Florian Schmidt, Zahid Nawaz, Kian Leong Lee, Prasanna Nori Venkatesh, Meera Makheja, Zhu En Chan, Mengge Yu, Nirmala Arul Rayan, Michelle Gek Liang Lim, Alice Cheung, Sudipto Bari, John Ouyang, Owen Rackham, Tuan Zea Tan, William YK Hwang, Charles Chuah, Shyam Prabhakar, Sin Tiong Ong
Publikováno v:
Blood. 140:792-794
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d8334c30fb1c9cd65ada721901d59c
https://doi.org/10.1182/blood-2022-165758
https://doi.org/10.1182/blood-2022-165758
Autor:
Lingling Hu, Zuxianglan Zhao, Un In Chan, Michelle Gek Liang Lim, Xin Chen, Wing-Kin Sung, Xiaoling Xu, Peiyong Guan, Nitin Narwade, Mokan Deng, Chandana Tennakoon, Zikai Chen, Edwin Cheung
Publikováno v:
Oncogene. 40:6479-6493
Androgen receptor (AR) plays a central role in driving prostate cancer (PCa) progression. How AR promotes this process is still not completely clear. Herein, we used single-cell transcriptome analysis to reconstruct the transcriptional network of AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f9c1582582d5ff83d44839dba8f5f4
https://doi.org/10.1038/s41388-021-02026-7
https://doi.org/10.1038/s41388-021-02026-7
Autor:
Bobby Ranjan, Wenjie Sun, Jinyu Park, Kunal Mishra, Ronald Xie, Fatemeh Alipour, Vipul Singhal, Florian Schmidt, Ignasius Joanito, Nirmala Arul Rayan, Michelle Gek Liang Lim, Shyam Prabhakar
Feature selection (marker gene selection) is widely believed to improve clustering accuracy, and is thus a key component of single cell clustering pipelines. However, we found that the performance of existing feature selection methods was inconsisten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e211c1b6cab0b7074095ba9675a3ddd
https://doi.org/10.1101/2020.10.07.330563
https://doi.org/10.1101/2020.10.07.330563
Autor:
Edwin Cheung, Yi Xiang See, Detu Zhu, Xin Chen, Michelle Gek Liang Lim, Dajiang Guo, Guimei Cui, Yumei Luo, Xianglan Zhaozu, Shiehong Chang, Paul Robson
Estrogen regulates diverse physiological effects and drives breast tumor progression by directly activating estrogen receptor α (ERα). However, due to the stochastic nature of gene transcription and the resulting heterogeneous cellular response, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ad766863eceb91c289c72764fb524c
https://doi.org/10.1101/246363
https://doi.org/10.1101/246363
Autor:
Qian Lu, Jiamiao Hu, Michelle Gek Liang Lim, Shanshan Liu, Xiaodi Su, Kin Yip Tam, X.M. Wang, Kamesh Narasimhan, Prasanna R. Kolatkar, Congling Chen, Shie Hong Chang, Si Kee Tan, Ralf Jauch, Guimei Cui, Siu Yee New, Edwin Cheung, Harapriya Chakravarty
Publikováno v:
The Biochemical journal. 475(11)
AP-2 gamma (AP-2γ) is a transcription factor that plays pivotal roles in breast cancer biology. To search for small molecule inhibitors of AP-2γ, we performed a high-throughput fluorescence anisotropy screen and identified a polyoxometalate compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b999fb46a7748c96ba4c79fd95e115b
https://pubmed.ncbi.nlm.nih.gov/29760237
https://pubmed.ncbi.nlm.nih.gov/29760237