Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michelle Fournier"'
Autor:
Cassandra L. Sather, Pamela Yang, Chaomei Zhang, Matthew P. Fitzgibbon, Michelle Fournier, Eric Toloza, Amit Tandon, Matthew Schabath, Sean Yoder, Viswam S. Nair
Publikováno v:
Cancer Medicine, Vol 12, Iss 17, Pp 17632-17637 (2023)
Abstract Introduction We investigated a commercially available sequencing panel to study the effect of sequencing depth, variant calling strategy, and targeted sequencing region on identifying tumor‐derived variants in cell‐free bronchoalveolar l
Externí odkaz:
https://doaj.org/article/1b5dbec6d7904d55a7856255aa1f6a45
Autor:
Jonathan Nguyen, Jamie K Teer, Liang Wang, Anders Berglund, Fengshen Kuo, Jad Chahoud, Jasreman Dhillon, Youngchul Kim, Ali Hajiran, James J Mulé, Andrew Chang, Nicholas H Chakiryan, Gregory J Kimmel, Carlos Moran-Segura, Daryoush Saeed-Vafa, Esther N Katende, Neale Lopez-Blanco, Phillip Rappold, Philippe E Spiess, Michelle Fournier, Daniel Jeong, Abraham Ari Hakimi, Philipp M Altrock, Brandon J Manley
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Introduction In clear cell renal cell carcinoma (ccRCC), tumor-associated macrophage (TAM) induction of CD8+T cells into a terminally exhausted state has been implicated as a major mechanism of immunotherapy resistance, but a deeper biological unders
Externí odkaz:
https://doaj.org/article/2881fd9f660e47b2a1d040258d55687f
Autor:
Nicholas H Chakiryan, Gregory J Kimmel, Youngchul Kim, Ali Hajiran, Ahmet M Aydin, Logan Zemp, Esther Katende, Jonathan Nguyen, Neale Lopez-Blanco, Jad Chahoud, Philippe E Spiess, Michelle Fournier, Jasreman Dhillon, Liang Wang, Carlos Moran-Segura, Asmaa El-Kenawi, James Mulé, Philipp M Altrock, Brandon J Manley
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0245415 (2021)
Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate oncogenic signaling through paracrine interactions with tumor cells, which may be better reflected
Externí odkaz:
https://doaj.org/article/805e9012c35c46a7a9bcfa1b146ddd89
Autor:
Nicholas H. Chakiryan, Gregory J. Kimmel, Youngchul Kim, Joseph O. Johnson, Noel Clark, Ali Hajiran, Andrew Chang, Ahmet M. Aydin, Logan Zemp, Esther Katende, Jad Chahoud, Meghan C. Ferrall-Fairbanks, Philippe E. Spiess, Natasha Francis, Michelle Fournier, Jasreman Dhillon, Jong Y. Park, Liang Wang, James J. Mulé, Philipp M. Altrock, Brandon J. Manley
Publikováno v:
Cancers, Vol 13, Iss 15, p 3743 (2021)
Cancer-associated fibroblasts (CAF) are highly prevalent cells in the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). CAFs exhibit a pro-tumor effect in vitro and have been implicated in tumor cell proliferation, metastasis, and tr
Externí odkaz:
https://doaj.org/article/0a47f57700cd435bac61490e87e712c1
Autor:
Jennifer Permuth-Wey, Y Ann Chen, Kate Fisher, Susan McCarthy, Xiaotao Qu, Mark C Lloyd, Agnieszka Kasprzak, Michelle Fournier, Vonetta L Williams, Kavita M Ghia, Sean J Yoder, Laura Hall, Christina Georgeades, Funmilayo Olaoye, Kazim Husain, Gregory M Springett, Dung-Tsa Chen, Timothy Yeatman, Barbara Ann Centeno, Jason Klapman, Domenico Coppola, Mokenge Malafa
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116869 (2015)
BACKGROUND:Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic ductal adenocarcinoma (PDAC) precursors. Differentiating between high-risk IPMNs that warrant surgical resection and low-risk IPMNs that can be monitored is a significant clin
Externí odkaz:
https://doaj.org/article/f9b5e8d0fb8b46b4957c592ee9a83ced
Autor:
Philipp M. Altrock, Brandon J. Manley, George Blanck, Esther N. Katende, Juan F. Arturo, Seyed Shayan A. Falasiri, Jasreman Dhillon, Erin M. Siegel, Michelle Fournier, James J. Mulé, Anders Berglund, Jamie K. Teer, Youngchul Kim, Boris I. Chobrutskiy, Nicholas H. Chakiryan, Meghan C. Ferrall-Fairbanks
Immune-modulating systemic therapies are often used to treat advanced cancer such as metastatic clear cell renal cell carcinoma (ccRCC). Used alone, sequence-based biomarkers neither accurately capture patient dynamics nor the tumor immune microenvir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d540b3511a9e533cde12d885f6ed3a63
https://doi.org/10.1158/0008-5472.c.6513682.v1
https://doi.org/10.1158/0008-5472.c.6513682.v1
Autor:
Christine H. Chung, Juan C. Hernandez-Prera, Jose Conejo-Garcia, Bruce M. Wenig, Louis Harrison, Jimmy Caudell, J. Trad Wadsworth, Matthew B. Schabath, Erin M. Siegel, Michelle Fournier, Feifei Song, Ritu Chaudhary, Jude Masannat, Tessa van Veen, Garrick Aden-Buie, Travis A. Gerke, Aik Choon Tan, Jamie K. Teer, Xuefeng Wang, Laura Martin-Gomez, Robbert J.C. Slebos, Janis V. de la Iglesia
Purpose:Patients with head and neck squamous cell carcinoma (HNSCC) who actively smoke during treatment have worse survival compared with never-smokers and former-smokers. We hypothesize the poor prognosis in tobacco smokers with HNSCC is, at least i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c7c2838d073ce3ceba5ee6539b5317
https://doi.org/10.1158/1078-0432.c.6528336
https://doi.org/10.1158/1078-0432.c.6528336
Autor:
Philipp M. Altrock, Brandon J. Manley, George Blanck, Esther N. Katende, Juan F. Arturo, Seyed Shayan A. Falasiri, Jasreman Dhillon, Erin M. Siegel, Michelle Fournier, James J. Mulé, Anders Berglund, Jamie K. Teer, Youngchul Kim, Boris I. Chobrutskiy, Nicholas H. Chakiryan, Meghan C. Ferrall-Fairbanks
Supplementary Data from Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8eb4693dd42e01954e2fbfd2cfff7c
https://doi.org/10.1158/0008-5472.22430668
https://doi.org/10.1158/0008-5472.22430668
Autor:
Nicholas H Chakiryan, Youngchul Kim, Anders Berglund, Andrew Chang, Gregory J Kimmel, Ali Hajiran, Jonathan Nguyen, Carlos Moran-Segura, Daryoush Saeed-Vafa, Esther N Katende, Neale Lopez-Blanco, Jad Chahoud, Phillip Rappold, Philippe E Spiess, Michelle Fournier, Daniel Jeong, Liang Wang, Jamie K Teer, Jasreman Dhillon, Fengshen Kuo, Abraham Ari Hakimi, Philipp M Altrock, James J Mulé, Brandon J Manley
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e006195
IntroductionIn clear cell renal cell carcinoma (ccRCC), tumor-associated macrophage (TAM) induction of CD8+T cells into a terminally exhausted state has been implicated as a major mechanism of immunotherapy resistance, but a deeper biological underst
Autor:
Louis B. Harrison, Laura Martin-Gomez, Michelle Fournier, Christine H. Chung, Jamie K. Teer, Feifei Song, Erin M. Siegel, Aik Choon Tan, Jude Masannat, Jose R. Conejo-Garcia, Matthew B. Schabath, Garrick Aden-Buie, Juan C. Hernandez-Prera, Bruce M. Wenig, Janis V. de la Iglesia, Robbert J.C. Slebos, Travis Gerke, Jimmy J. Caudell, Ritu Chaudhary, Tessa Van Veen, J. Trad Wadsworth, Xuefeng Wang
Publikováno v:
Clinical Cancer Research. 26:1474-1485
Purpose: Patients with head and neck squamous cell carcinoma (HNSCC) who actively smoke during treatment have worse survival compared with never-smokers and former-smokers. We hypothesize the poor prognosis in tobacco smokers with HNSCC is, at least