Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michelle Fennen"'
Autor:
Michelle Fennen, Toni Weinhage, Vanessa Kracke, Johanna Intemann, Georg Varga, Corinna Wehmeyer, Dirk Foell, Adelheid Korb-Pap, Thomas Pap, Berno Dankbar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The interactions of fibroblast-like synoviocyte (FLS)-derived pro-inflammatory cytokines/chemokines and immune cells support the recruitment and activation of inflammatory cells in RA. Here, we show for the first time that the classical myok
Externí odkaz:
https://doaj.org/article/0e68a05c59a446c9abd58a77cfaf8633
Autor:
Vanessa Waltereit-Kracke, Corinna Wehmeyer, Denise Beckmann, Eugenie Werbenko, Julia Reinhardt, Fabienne Geers, Mike Dienstbier, Michelle Fennen, Johanna Intemann, Peter Paruzel, Adelheid Korb-Pap, Thomas Pap, Berno Dankbar
Publikováno v:
Annals of the rheumatic diseases. 81(8)
ObjectiveThe aim of this study was to assess the extent and the mechanism by which activin A contributes to progressive joint destruction in experimental arthritis and which activin A-expressing cell type is important for disease progression.MethodsL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0213edcba31a7576446349fc61897449
https://pubmed.ncbi.nlm.nih.gov/35418478
https://pubmed.ncbi.nlm.nih.gov/35418478
Autor:
Thomas Pap, Peter Paruzel, Berno Dankbar, David J. J. de Gorter, Michelle Fennen, Johanna Intemann, V Kracke, E Werbenko
Publikováno v:
Abstracts.
Career situation of first and presenting author Student for a master or a PhD. Introduction Activins and inhibins belong to the transforming growth factor β family. Activins are disulphide-linked homo- or heterodimers consisting of two inhibin β ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e71287c3f967fd59e88ed30981db86
https://doi.org/10.1136/annrheumdis-2018-ewrr2019.54
https://doi.org/10.1136/annrheumdis-2018-ewrr2019.54
Publikováno v:
Poster presentations.
Introduction Activins and inhibins belong to the transforming growth factor β family. Activins are disulphide-linked homo- or heterodimers consisting of two inhibin β chains (βA, βB) that are expressed in many cell types. However, activin A (βA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f23ceac16c4959d008342d982764fa7
https://doi.org/10.1136/annrheumdis-2018-ewrr2018.90
https://doi.org/10.1136/annrheumdis-2018-ewrr2018.90
Publikováno v:
New players and novel targets in inflammation.
Background Myostatin, a secreted member of the transforming growth factor-β (TGF-β) family, is predominantly expressed in skeletal muscle and negatively regulates muscle growth. We previously demonstrated that myostatin deficiency leads to reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f906e9c53d92a3d775f15972dc0d833b
https://doi.org/10.1136/annrheumdis-2016-211050.27
https://doi.org/10.1136/annrheumdis-2016-211050.27
Autor:
Mayken Visser, Martin Brodde, Beate E. Kehrel, Michelle Fennen, Anke C. Fender, Reinhard Kelsch, Janina Treffon, Anne Bertling
Publikováno v:
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie. 44(5)
Background: Hemarthrosis, or bleeding into the joints, is a hallmark of hemophilia. Heme triggers oxidative stress, inflammation, and destruction of cartilage and bone. The haptoglobin-CD163-heme oxygenase-1 (HO-1) pathway circumvents heme toxicity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5d0404d79f648846c8663afa71c3da
https://pubmed.ncbi.nlm.nih.gov/29070980
https://pubmed.ncbi.nlm.nih.gov/29070980
Autor:
Ina Kramer, Michelle Fennen, Denise Beckmann, Athanasios Stratis, Svetlana Frank, Corinna Wehmeyer, Thomas Kamradt, Thomas Pap, U König, Michaela Kneissel, Berno Dankbar, Peter Paruzel, Adelheid Korb-Pap, Annelena Held, Christine Hartmann, C Cromme, Martin Böttcher, Wim B. van den Berg
Publikováno v:
Science Translational Medicine, 8, 330ra35-330ra35
Science Translational Medicine, 8, 330, pp. 330ra35-330ra35
Science Translational Medicine, 8, 330, pp. 330ra35-330ra35
Item does not contain fulltext Sclerostin, an inhibitor of the Wnt/beta-catenin pathway, has anti-anabolic effects on bone formation by negatively regulating osteoblast differentiation. Mutations in the human sclerostin gene (SOST) lead to sclerosteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2cb601ee469ac657bffbaaf1a018f9
http://hdl.handle.net/2066/171465
http://hdl.handle.net/2066/171465
Autor:
Jessica Bertrand, Thomas Pap, Adelheid Korb-Pap, Peter Paruzel, Daniela Brunert, Svetlana Frank, Kurt Redlich, Denise Beckmann, Berno Dankbar, Corinna Wehmeyer, Silvia Hayer, Athanasios Stratis, Michelle Fennen, Christina Koers-Wunrau
Publikováno v:
Nature medicine. 21(9)
Myostatin is shown to directly promote osteoclast differentiation, and its inhibition improves arthritic bone loss in two mouse models. Myostatin (also known as growth and differentiation factor 8) is a secreted member of the transforming growth fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89599289a488d85c24177d8870f55ee3
https://pubmed.ncbi.nlm.nih.gov/26388227
https://pubmed.ncbi.nlm.nih.gov/26388227
Autor:
Denise Beckmann, U König, Peter Paruzel, C Cromme, Annelena Held, Adelheid Korb-Pap, Ina Kramer, Martin Böttcher, Michelle Fennen, Thomas Pap, Michaela Kneissel, Christine Hartmann, W.B. van den Berg, Corinna Wehmeyer, Svetlana Frank, Athanasios Stratis, Thomas Kamradt, Berno Dankbar
Publikováno v:
Annals of the Rheumatic Diseases. 75:A78.1-A78
Background and objectives Wnt-inhibitor sclerostin has anti-anabolic effects on bone formation by negatively regulating osteoblast differentiation. Loss of sclerostin expression results in high bone mass and bone strength in patients with sclerosteos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c68e28ed0df936269b5a1627498048b2
https://doi.org/10.1136/annrheumdis-2016-209124.186
https://doi.org/10.1136/annrheumdis-2016-209124.186