Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michelle Eugeni"'
Autor:
Li Chen, Biswajit Das, Ting-Chia Chang, Yvonne A. Evrard, Chris A. Karlovich, Alyssa Chapman, Brandie Fullmer, Ashley Hayes, Ruth Thornton, Nikitha Nair, Shahanawaz Jiwani, Lindsay Dutko, Kelly Benauer, Gloryvee Rivera, Corinne Camalier, John Carter, Suzanne Borgel, Tiffanie Miner, Chelsea McGlynn, Justine Mills, Shannon Uzelac, Tia Shearer, Lauren Hicks, Michelle Norris, Carley Border, Sergio Alcoser, Thomas Walsh, Michael Mullendore, Michelle Eugeni, Dianne Newton, Melinda G. Hollingshead, P. Mickey Williams, James H. Doroshow
Publikováno v:
Cancer Research. 83:6072-6072
Introduction: Structural variants (SVs) are a unique class of mutations which have certain therapeutic implications for the tumor. Certain SVs, such as chromosomal aneuploidy, whole-genome doubling (WGD), have specific therapeutic implications. The u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d9f6fce97020668d97e29fc5d2a9ed7
https://doi.org/10.1158/1538-7445.am2023-6072
https://doi.org/10.1158/1538-7445.am2023-6072
Autor:
Peter I. Wu, Lindsay Dutko, Shahanawaz Jiwani, Li Chen, Biswajit Das, Ting-Chia Chang, Yvonne A. Evrard, Chris A. Karlovich, Alyssa Chapman, Brandie Fullmer, Ashley Hayes, Ruth Thornton, Nikitha Nair, Kelly Benauer, Gloryvee Rivera, Thomas Forbes, John Carter, Suzanne Borgel, Tiffanie Miner, Chelsea McGlynn, Justine Mills, Shannon Uzelac, Tia Shearer, Lauren Hicks, Michelle Norris, Carley Border, Sergio Alcoser, Thomas Walsh, Michael Mullendore, Michelle Eugeni, Dianne Newton, Melinda G. Hollingshead, P. M. Williams, James H. Doroshow
Publikováno v:
Cancer Research. 83:2050-2050
Background: Breast cancer is the second most common cancer in women. In 2022, it accounted for 15% of total new cancer cases and is the number four cause of death among all cancer types. To benefit from precision medicine, distinguishing molecular su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d64a43a4a3d5a16ac42b2936c7c001d2
https://doi.org/10.1158/1538-7445.am2023-2050
https://doi.org/10.1158/1538-7445.am2023-2050
Autor:
Yvonne A. Evrard, Michelle Eugeni, Michelle Ahalt-Gottholm, Carrie Bonomi, Suzanne Borgel, Thomas C. Caffrey, John Carter, Ting-Chia Chang, Li Chen, Kevin Cooper, Biswajit Das, Emily Delaney, Kelly Dougherty, Eleonora Duregon, Stephanie Ecker, Joe Geraghty, Marion Gibson, Lauren Hicks, Jenna Hull, Sharon Int Veldt, Shahanawaz Jiwani, Chris A. Karlovich, Jade Loewenstein, Candace Mallow, Chelsea McGlynn, Justine Mills, Tiffanie Miner, Jowaly Schneider, Tia Shearer, Savanna Styers, Shannon Uzelac, Paul Grandgenett, Michael Hollingsworth, Jody E. Hooper, P. Mickey Williams, Melinda Hollingshead, James H. Doroshow
Publikováno v:
Cancer Research. 82:3120-3120
NCI’s Patient-Derived Models Repository (NCI PDMR; pdmr.cancer.gov) has developed a variety of patient-derived models across most solid tumor histologies. These models are early passage, genetically characterized and associated with limited patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf1f9401b8cebbccb6a0db364baac75
https://doi.org/10.1158/1538-7445.am2022-3120
https://doi.org/10.1158/1538-7445.am2022-3120
Autor:
Michael Mullendore, Jenna Hull, P. Mickey Williams, Cindy R. Timme, Dianne L. Newton, Tia Shearer, Shahanawaz Jiwani, Li Chen, Chris Karlovich, Michelle Eugeni, Tara Grinnage-Polley, James H. Doroshow, Kristen Cooley, Tom Walsh, Devynn Breen, Emily Delaney, Kimberly Klarmann, Michelle M. Gottholm-Ahalt, Melinda G. Hollingshead, Jesse Stottlemyer, Chelsea McGlynn, Malorie Morris, John Mark Carter, Yvonne A. Evrard, Alice P. Chen, Ting-Chia Chang, Candace Mallow, Sergio Y. Alcoser, Shannon Uzelac, Biswajit Das, Justine Mills
Publikováno v:
Cancer Research. 81:3012-3012
There is an unmet need for preclinical models of rare cancers and rare disease sub-types. The National Cancer Institute's Patient-Derived Models Repository (NCI PDMR; https://pdmr.cancer.gov) is developing quality-controlled, early-passage, clinicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::757e2a22cf2c12f6010f339ad111d301
https://doi.org/10.1158/1538-7445.am2021-3012
https://doi.org/10.1158/1538-7445.am2021-3012
Autor:
Michelle M. Gottholm Ahalt, Kelly Benauer, Jesse Stottlemyer, Vishnuprabha Rahulkannan, Michelle Eugeni, James H. Doroshow, Gloryvee Rivera, Lindsay Dutko, Tiffanie Chase, Erin Cantu, Melinda G. Hollingshead, Yvonne A. Evrard, Biswajit Das, Suzanne Borgel, Mickey Williams, Emily Delaney, Shahanawaz Jiwani, Chris Karlovich, Howard Stotler, Chelsea McGlynn, John Mark Carter
Publikováno v:
Cancer Research. 81:3015-3015
Background: Well characterized patient derived xenograft models (PDX) are becoming the preferred pre-clinical tool in translational cancer research for biologic understanding of the disease, development of new treatments, and identifying potential th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d8fd10282625992ef9dc6462e149a0a
https://doi.org/10.1158/1538-7445.am2021-3015
https://doi.org/10.1158/1538-7445.am2021-3015
Autor:
Lindsay Dutko, Shahanawaz Jiwani, Dianne L. Newton, Li Chen, Chris Karlovich, Michelle Eugeni, James H. Doroshow, Kelly Benauer, P. Mickey Williams, Nikitha Nair, Chapman Alyssa, Anna L. Fong, Biswajit Das, Luis E. Romero, Melinda G. Hollingshead, Yvonne A. Evrard, Ting-Chia Chang, Tomas Vilimas, Kelly Dougherty, Amanda Peach, Marianne Morton
Publikováno v:
Cancer Research. 81:3139-3139
Background: A major set of preclinical models derived from specimens acquired from rapid autopsy patients in the National Cancer Institute Patient-Derived Models Repository (NCI PDMR, https://pdmr.cancer.gov) were from pancreatic adenocarcinoma (PAAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccf1d0734d72c24445af4c3ceea64c57
https://doi.org/10.1158/1538-7445.am2021-3139
https://doi.org/10.1158/1538-7445.am2021-3139
Autor:
Li Chen, Yvonne A. Evrard, Michelle Eugeni, Kelly Benauer, Amanda Peach, Michelle M. Gottholm Ahalt, James H. Doroshow, Shahanawaz Jiwani, Biswajit Das, Chris Karlovich, John Carter, Candace Mallow, Tara Grinnage-Pulley, Lindsay Dutko, Tiffanie L. Miner, Sergio Y. Alcoser, Dianne L. Newton, Devynn Breen, Thomas Forbes, Emily Delaney, Alyssa K. Chapman, Marianne Radzyminski, Anna J. Lee Fong, Shannon Uzelac, Chelsea McGlynn, Tomas Vilimas, Brandie A. Fullmer, Luis E. Romero, Gloryvee Rivera, Suzanne Borgel, Robin D. Harrington, Justine N. McCutcheon, Rajesh Patidar, Jesse Stottlemyer, Vishnuprabha R. Kannan, Nikitha Nair, Erin Cantu, Peng Wang, Melinda G. Hollingshead, Kelsey A. Conley, Paul Williams
Publikováno v:
Cancer Research. 80:3554-3554
Background: Acquired Uniparental Disomy (aUPD) is relatively common in cancer. Occurrence of aUPD is more frequent in some tumor histologies (e.g., serous ovarian, colorectal) and may be relevant for choice of therapy. The Patient-Derived Models Repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f91fc50253d9f2a655af90e763ab6c87
https://doi.org/10.1158/1538-7445.am2020-3554
https://doi.org/10.1158/1538-7445.am2020-3554
Autor:
Paul Williams, Lindsay Dutko, Marianne Radzyminski, Li Chen, Yvonne A. Evrard, Melinda G. Hollingshead, Anna Lee Fong, Luis Romero, James H. Doroshow, Tomas Vilimas, Dianne L. Newton, Rajesh Patidar, Shahanawaz Jiwani, Kelly Benauer, Chris Karlovich, Michelle Eugeni, Nikitha Nair, Biswajit Das, Kelly Dougherty, Amanda Peach
Publikováno v:
Journal of Clinical Oncology. 38:e13506-e13506
e13506 Background: The National Cancer Institute has developed a repository of preclinical models [Patient-Derived Models Repository (NCI PDMR, https://pdmr.cancer.gov )] including patient derived xenografts (PDXs), organoids (PDOrgs) and in vitro tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365366c976833f67ad3900948bc6dc54
https://doi.org/10.1200/jco.2020.38.15_suppl.e13506
https://doi.org/10.1200/jco.2020.38.15_suppl.e13506
Autor:
James H. Doroshow, Zhigang Kang, Cody J. Peer, Paula M. Jacobs, Liang Cao, Michelle Eugeni, William D. Figg, Seth M. Steinberg, Peter L. Choyke, Khanh T. Do, Shivaani Kummar, Mark Raffeld, Erin Larkins, Maria Liza Lindenberg, John Wright, Beata Holkova, Baris Turkbey
Publikováno v:
Clinical Colorectal Cancer. 14:154-161
Background Mutations in the KRAS gene predict for resistance to anti-epidermal growth factor receptor (EGFR) therapies, including cetuximab. Upregulation of vascular endothelial growth factor (VEGF)-A has been implicated in resistance to anti-EGFR tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77c80241a81e4cb78d3301dfde80a919
https://doi.org/10.1016/j.clcc.2015.02.007
https://doi.org/10.1016/j.clcc.2015.02.007
Autor:
James H. Doroshow, Manuel B. Datiles, Giovanna Speranza, Robert J. Kinders, Khanh T. Do, Michelle Eugeni, Michael H. Lam, Larry Rubinstein, Sonny Khin, Shivaani Kummar, L. Austin Doyle, Rachel Bishop
Publikováno v:
Invest New Drugs
PURPOSE: PI3K/AKT/mTOR and RAS/RAF/MEK pathways are frequently dysregulated in colorectal cancer (CRC). We conducted a biomarker-driven trial of the combination of MK-2206, an allosteric AKT 1/2/3 inhibitor, and selumetinib, a MEK 1/2 inhibitor, in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e1fa6d4c2cc18bf451a5055864690f
https://doi.org/10.1007/s10637-015-0212-z
https://doi.org/10.1007/s10637-015-0212-z