Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michelle E. McCully"'
Publikováno v:
Journal of Computational Chemistry. 43:197-205
The engineered three-helix bundle, UVF, is thermostabilized entropically due to heightened, native-state dynamics. However, it is unclear whether this thermostabilization strategy is observed in natural proteins from thermophiles. We performed all-at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1675cbac06cfa971931169c653eda4de
https://doi.org/10.1002/jcc.26782
https://doi.org/10.1002/jcc.26782
Autor:
Matthew Gill, Michelle E. McCully
Publikováno v:
Protein Engineering, Design and Selection
Designing functional proteins that can withstand extreme heat is beneficial for industrial and protein therapeutic applications. Thus, elucidating the atomic-level determinants of thermostability is a major interest for rational protein design. To th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45af64574041629a11c4de6a7d2f08b3
http://europepmc.org/articles/PMC7052480
http://europepmc.org/articles/PMC7052480
Autor:
Paulo Henrique Borges Ferreira, Ronaldo Junio de Oliveira, Gabriel Gouvêa Slade, Michelle E. McCully, Frederico Campos Freitas
Publikováno v:
J Chem Inf Model
Understanding which aspects contribute to the thermostability of proteins is a challenge that has persisted for decades, and it is of great relevance for protein engineering. Several types of interactions can influence the thermostability of a protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce41115b17b83a5395e053fbbdca7c78
https://doi.org/10.1021/acs.jcim.9b00797
https://doi.org/10.1021/acs.jcim.9b00797
Publikováno v:
Protein Eng Des Sel
Protein stability, dynamics and function are intricately linked. Accordingly, protein designers leverage dynamics in their designs and gain insight to their successes and failures by analyzing their proteins’ dynamics. Molecular dynamics (MD) simul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6764a8123be8caf7c59d6ddd7fc5ef9b
https://doi.org/10.1093/protein/gzac001
https://doi.org/10.1093/protein/gzac001
Publikováno v:
Biophysical Journal. 122:39a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baf6efd605cd4711b0835f8598885cdf
https://doi.org/10.1016/j.bpj.2022.11.422
https://doi.org/10.1016/j.bpj.2022.11.422
Autor:
Gabriel Gouvêa Slade, Catrina Nguyen, Ronaldo Junio de Oliveira, Jennifer T. Young, Michelle E. McCully
Publikováno v:
Biophysical Journal
Thermostable proteins are advantageous in industrial applications, as pharmaceuticals or biosensors, and as templates for directed evolution. As protein-design methodologies improve, bioengineers are able to design proteins to perform a desired funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f341f6db39931614bc37ea72efbc653
http://europepmc.org/articles/PMC6382955
http://europepmc.org/articles/PMC6382955
Autor:
Qiang, Cui, Michelle E, McCully
Publikováno v:
Curr Opin Struct Biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5271ae7ea3f452dcfdf4531f2b0811b6
https://doi.org/10.1016/j.sbi.2022.102347
https://doi.org/10.1016/j.sbi.2022.102347
Publikováno v:
Biophysical Journal. 118:199a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f49114f8039f658d1ad8d27d2673d098
https://doi.org/10.1016/j.bpj.2019.11.1199
https://doi.org/10.1016/j.bpj.2019.11.1199
Publikováno v:
Biophysical Journal. 118:198a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a7362cd4b04ab6bd7e47c9484a86554
https://doi.org/10.1016/j.bpj.2019.11.1196
https://doi.org/10.1016/j.bpj.2019.11.1196
Publikováno v:
Biophysical Journal. 118:511a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::538519b3d72f569292097e86daa4c962
https://doi.org/10.1016/j.bpj.2019.11.2816
https://doi.org/10.1016/j.bpj.2019.11.2816