Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Michelle E. Maxson"'
Autor:
Nicola T. Case, Johannes Westman, Michael T. Hallett, Jonathan Plumb, Aiman Farheen, Michelle E. Maxson, Jessie MacAlpine, Sean D. Liston, Bernhard Hube, Nicole Robbins, Luke Whitesell, Sergio Grinstein, Leah E. Cowen
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTFor the human fungal pathogen Candida albicans, metabolic flexibility and the ability to transition between yeast and filamentous growth states are key virulence traits that enable disease in the host. These traits are particularly important
Externí odkaz:
https://doaj.org/article/9701e5721a294187994ac9a51a0381cf
Autor:
Nicole M. Revie, Kali R. Iyer, Michelle E. Maxson, Jiabao Zhang, Su Yan, Caroline M. Fernandes, Kirsten J. Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, Hiram Sanchez, Saif Hossain, Sheena Li, Yoko Yashiroda, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S. Shapiro, David R. Andes, Gerard D. Wright, Justin R. Nodwell, Maurizio Del Poeta, Martin D. Burke, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
There is an urgent need for novel strategies to combat life-threatening fungal infections. Here, Revie et al. identify a compound that induces alterations in fungal membranes, synergizes with azole antifungals against the pathogen Candida albicans, a
Externí odkaz:
https://doaj.org/article/8bca44075efb4f07a12ae3b736c09d4d
Autor:
Michelle E. Maxson, Lahari Das, Michael F. Goldberg, Steven A. Porcelli, John Chan, William R. Jacobs
Publikováno v:
Pathogens, Vol 12, Iss 9, p 1109 (2023)
Metabolic dysregulation in Mycobacterium tuberculosis results in increased macrophage apoptosis or pyroptosis. However, mechanistic links between Mycobacterium virulence and bacterial metabolic plasticity remain ill defined. In this study, we screene
Externí odkaz:
https://doaj.org/article/e7bcd4d6b45a4a1ea9b8a66f2e8537cd
Autor:
Teresa R. O’Meara, Kwamaa Duah, Cynthia X. Guo, Michelle E. Maxson, Ryan G. Gaudet, Kristy Koselny, Melanie Wellington, Michael E. Powers, Jessie MacAlpine, Matthew J. O’Meara, Amanda O. Veri, Sergio Grinstein, Suzanne M. Noble, Damian Krysan, Scott D. Gray-Owen, Leah E. Cowen
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
ABSTRACT The innate immune system is the first line of defense against invasive fungal infections. As a consequence, many successful fungal pathogens have evolved elegant strategies to interact with host immune cells. For example, Candida albicans un
Externí odkaz:
https://doaj.org/article/37c1c8c11e4b4ed3843ff6f59b92ef9d
While it has been known for decades that luminal acidification is required for normal traffic along the endocytic pathway, the precise underlying mechanism(s) remain unknown. We found that dissipation of the endomembrane pH gradient resulted in acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::428c68b2103346d664996a8707d7f784
https://doi.org/10.1101/2023.02.15.528749
https://doi.org/10.1101/2023.02.15.528749
Autor:
Michelle E Maxson, Xenia Naj, Teresa R O'Meara, Jonathan D Plumb, Leah E Cowen, Sergio Grinstein
Publikováno v:
eLife, Vol 7 (2018)
Candida albicans hyphae can reach enormous lengths, precluding their internalization by phagocytes. Nevertheless, macrophages engulf a portion of the hypha, generating incompletely sealed tubular phagosomes. These frustrated phagosomes are stabilized
Externí odkaz:
https://doaj.org/article/446d286d3d1e499ca2bb896bdb8609ea
Autor:
Michelle E. Maxson, Yazan M. Abbas, Jing Ze Wu, Jonathan D. Plumb, Sergio Grinstein, John L. Rubinstein
Publikováno v:
Journal of Cell Biology. 221
Acidification of secretory and endocytic organelles is required for proper receptor recycling, membrane traffic, protein degradation, and solute transport. Proton-pumping vacuolar H+ ATPases (V-ATPases) are responsible for this luminal acidification,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90aaed18dcc8282e0cbaf9016131633
https://doi.org/10.1083/jcb.202107174
https://doi.org/10.1083/jcb.202107174
Acidification of secretory and endocytic organelles is required for proper receptor recycling, membrane traffic, protein degradation, and solute transport. Proton-pumping vacuolar ATPases (V-ATPases) are responsible for this luminal acidification, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76eeb3cb52197c52bcf9d16b72eef9c
https://doi.org/10.1101/2021.07.29.454369
https://doi.org/10.1101/2021.07.29.454369
Publikováno v:
Journal of Leukocyte Biology. 106:837-851
Like other membrane receptor-mediated responses, execution of phagocytosis requires the transduction of signals to cytoplasmic effectors. Signaling in this case is particularly complex as the process involves not only the formation of phagosomes but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57631901ec94203c2c445e738009b071
https://doi.org/10.1002/jlb.mr1118-444r
https://doi.org/10.1002/jlb.mr1118-444r
Autor:
Bernhard Hube, Johannes Westman, Michelle E. Maxson, Mabel Yang, Stefanie Allert, Julian R. Naglik, Sergio Grinstein, Anna Licht, Jonathan Plumb
Publikováno v:
SSRN Electronic Journal.
Candida albicans is both a commensal and an opportunistic fungal pathogen. Invading hyphae of C. albicans secrete candidalysin, a pore-forming peptide toxin. To prevent cell death, epithelial cells must protect themselves from direct damage induced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0f5683dc8ed69e58d5b9719979fa95d
https://doi.org/10.2139/ssrn.3877395
https://doi.org/10.2139/ssrn.3877395