Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michelle E. LeBlanc"'
Autor:
Zhengping Hu, Issahy Cano, Kahira L. Saez-Torres, Michelle E. LeBlanc, Magali Saint-Geniez, Yin-Shan Ng, Pablo Argüeso, Patricia A. D’Amore
Publikováno v:
Cells, Vol 9, Iss 6, p 1413 (2020)
Endomucin (EMCN) is the type I transmembrane glycoprotein, mucin-like component of the endothelial cell glycocalyx. We have previously shown that EMCN is necessary for vascular endothelial growth factor (VEGF)-induced VEGF receptor 2 (VEGFR2) interna
Externí odkaz:
https://doaj.org/article/32527e0a5dd34f8e9aae83b4878b641f
Autor:
Patricia A. D'Amore, Yin-Shan Ng, Magali Saint-Geniez, Michelle E. LeBlanc, Kahira L. Saez-Torres, Issahy Cano, Jinling Yang
Publikováno v:
J Biol Chem
Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes
Autor:
Michelle E LeBlanc, Weiwen Wang, Nora B Caberoy, Xiuping Chen, Feiye Guo, Gabriela Alvarado, Chen Shen, Feng Wang, Hui Wang, Rui Chen, Zhao-Jun Liu, Keith Webster, Wei Li
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127904 (2015)
Hepatoma-derived growth factor-related protein-3 (Hdgfrp3 or HRP-3) was recently reported as a neurotrophic factor and is upregulated in hepatocellular carcinoma to promote cancer cell survival. Here we identified HRP-3 as a new endothelial ligand an
Externí odkaz:
https://doaj.org/article/f10d966bddd14715910ec9504654a742
Autor:
Ying Ding, Nora B Caberoy, Feiye Guo, Michelle E LeBlanc, Chenming Zhang, Weiwen Wang, Feng Wang, Rui Chen, Wei Li
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126993 (2015)
Phagocytosis is critical to the clearance of apoptotic cells, cellular debris and deleterious metabolic products for tissue homeostasis. Phagocytosis ligands directly recognizing deleterious cargos are the key to defining the functional roles of phag
Externí odkaz:
https://doaj.org/article/99f77b0e1e264b49988da672cdde0013
Publikováno v:
Experimental Eye Research. 181:120-126
Wet age-related macular degeneration (AMD) with choroidal neovascularization (CNV) is a leading cause of vision loss in the elderly. The advent of anti-vascular endothelial growth factor (VEGF) drugs represents a major breakthrough in wet AMD therapy
Autor:
Weiwen Wang, Dan Liang, Fen Tang, Ping Chen, Michelle E. LeBlanc, Tsung Han Chou, Wei Li, Hong Tian
Publikováno v:
Angiogenesis
Retinopathy of Prematurity (ROP) with pathological retinal neovascularization is the most common cause of blindness in children. ROP is currently treated with laser therapy or cryotherapy, both of which may adversely affect the peripheral vision with
Autor:
Yanli Ji, Xiuping Chen, Feiye Guo, Wei Li, Nora B. Caberoy, Michelle E. LeBlanc, Hui Wang, Weiwen Wang, Hong Tian, Chen Shen, Rui Chen
Publikováno v:
The Journal of Experimental Medicine
LeBlanc et al. uncover secretogranin III (Scg3) as a unique disease-associated vascular permeability and angiogenic factor using comparative ligandomics. Scg3-neutralizing antibodies alleviate vascular leakage in diabetic retinopathy mice and retinal
Autor:
Michelle E. LeBlanc, Akhalesh Shakya, Ying Ding, Chenming Zhang, Xiuping Chen, Feiye Guo, Wei Li
Publikováno v:
Cell Biology and Toxicology. 32:347-358
Phagocytosis is a critical process to maintain tissue homeostasis. In the retina, photoreceptor cells renew their photoexcitability by shedding photoreceptor outer segments (POSs) in a diurnal rhythm. Shed POSs are phagocytosed by retinal pigment epi
Autor:
Yin-Shan Ng, Zhengping Hu, Patricia A. D'Amore, Michelle E. LeBlanc, Kahira L. Saez-Torres, Magali Saint-Geniez, Issahy Cano, Pablo Argüeso
Publikováno v:
Cells
Cells, Vol 9, Iss 1413, p 1413 (2020)
Volume 9
Issue 6
Cells, Vol 9, Iss 1413, p 1413 (2020)
Volume 9
Issue 6
Endomucin (EMCN) is the type I transmembrane glycoprotein, mucin-like component of the endothelial cell glycocalyx. We have previously shown that EMCN is necessary for vascular endothelial growth factor (VEGF)-induced VEGF receptor 2 (VEGFR2) interna
Autor:
Robert Liu, Nora B. Caberoy, Enrique Salero, Michelle E. LeBlanc, Yixiong Zhou, Weiwen Wang, Chen Shen, Feiye Guo, Wei Li, Ying Ding, Jisu Yu, Gabriela Alvarado
Publikováno v:
Journal of Cellular Biochemistry. 116:2177-2187
Phagocytosis is critical to tissue homeostasis, as highlighted by phagocytosis defect of retinal pigment epithelial (RPE) cells with debris accumulation, photoreceptor degeneration and blindness. Phagocytosis ligands are the key to delineating molecu