In vitro evolution and whole genome analysis to study chemotherapy drug resistance in haploid human cells

Autor: Juan Carlos Jado, Michelle Dow, Krypton Carolino, Adam Klie, Gregory J. Fonseca, Trey Ideker, Hannah Carter, Elizabeth A. Winzeler

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)

Abstract In vitro evolution and whole genome analysis has proven to be a powerful method for studying the mechanism of action of small molecules in many haploid microbes but has generally not been applied to human cell lines in part because their dip

Externí odkaz: https://doaj.org/article/393b41621ea749ec915b0726a2c71095

Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer

Autor: Gavin Frame, Hon Leong, Roni Haas, Xiaoyong Huang, Jessica Wright, Urban Emmenegger, Michelle Downes, Paul C. Boutros, Thomas Kislinger, Stanley K. Liu

Publikováno v: BJC Reports, Vol 2, Iss 1, Pp 1-11 (2024)

Abstract Background Metastatic relapse of prostate cancer after radiotherapy is a significant cause of prostate cancer-related morbidity and mortality. PLOD2 is a mediator of invasion and metastasis that we identified as being upregulated in our high

Externí odkaz: https://doaj.org/article/b2ba3ac36f624f9c9089750dd473d543

Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation

Autor: Daniel Karin, Xi-he Zhao, Mark D. Long, Kathleen M. Fisch, Sourav Banerjee, Laura Antonucci, Xue-Jia Lin, Yixuan Zhou, Zhang Cheng, Hua Su, Richard Bourgon, Christina Jamieson, Genevive Hernandez, Qui T. Phung, Tao Liu, Jennie R. Lill, Hongxia Wang, Ira Mellman, Lukas Kenner, Michelle Dow, Shabnam Shalapour, Song Liu, Michael Karin, Wei-Hua Li, Jian Yu Huang, Marcus Bosenberg, Johannes Haybaeck, Sylvia Choi, Rachael Katie Ngu, Ingmar N. Bastian, Hannah Carter, Mark H. Ellisman, Brian Dang

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 8

Significance T cells recognize their targets via their T-cell receptors (TCRs), which in the case of CD8+ T cells bind to MHC-I:antigen complexes on the surface of target cells. Many cancer cells evade immune recognition and killing by down-regulatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427c1d1f6f3579e37198bebe48653df1
http://europepmc.org/articles/PMC7923353

The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling

Autor: Russell Dekelver, Katherine Tin Heng Liu, Amanda G Davis, Su Xian, Dong-Er Zhang, Elizabeth T Andrews, Ming Yan, Mengdan Liu, Samuel A Stoner, Hannah Carter, Kei-ichiro Arimoto, Stephanie Weng, Michelle Dow

Publikováno v: Blood Cancer Journal
Blood Cancer Journal, Vol 10, Iss 2, Pp 1-14 (2020)
Blood cancer journal, vol 10, iss 2

Large-scale chromosomal translocations are frequent oncogenic drivers in acute myeloid leukemia (AML). These translocations often occur in critical transcriptional/epigenetic regulators and contribute to malignant cell growth through alteration of no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b10738adad210f89f3bb6050c60d80
http://europepmc.org/articles/PMC7005177

Genome privacy: challenges, technical approaches to mitigate risk, and ethical considerations in the United States

Autor: Lucila Ohno-Machado, Shuang Wang, Xiaoqian Jiang, Dov Fox, Michelle Dow, Siddharth Singh, Rebecca A. Marmor, Luca Bonomi

Publikováno v: Annals of the New York Academy of Sciences. 1387:73-83

Accessing and integrating human genomic data with phenotypes are important for biomedical research. Making genomic data accessible for research purposes, however, must be handled carefully to avoid leakage of sensitive individual information to unaut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d64451de5a9d2861ddf2e29c048532ed
https://doi.org/10.1111/nyas.13259