Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michelle Dewitt"'
Autor:
Buwei Huang, Brian Coventry, Marta T. Borowska, Dimitrios C. Arhontoulis, Marc Exposit, Mohamad Abedi, Kevin M. Jude, Samer F. Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Maggie Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance Stewart, Deborah H. Fuller, Ying Mei, K. Christopher Garcia, David Baker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Cytokine release syndrome (CRS), commonly known as cytokine storm, is an acute systemic inflammatory response that is a significant global health threat. Interleukin-6 (IL-6) and interleukin-1 (IL-1) are key pro-inflammatory cytokines involv
Externí odkaz:
https://doaj.org/article/5f93a3f590e5444ea2f8d8872b6aedb3
Autor:
Steven L. Bernstein, June Weiss, Michelle DeWitt, Jeanette M. Tetrault, Allen L. Hsiao, James Dziura, Scott Sussman, Ted Miller, Kelly Carpenter, Patrick O’Connor, Benjamin Toll
Publikováno v:
Implementation Science, Vol 14, Iss 1, Pp 1-11 (2019)
Abstract Background Smokers usually abstain from tobacco while hospitalized but relapse after discharge. Inpatient interventions may encourage sustained quitting. We previously demonstrated that a decision support tool embedded in an electronic healt
Externí odkaz:
https://doaj.org/article/bcd08ac72b394cc0aff60a3eded620a6
Autor:
Kejia Wu, Hua Bai, Ya-Ting Chang, Rachel Redler, Kerrie E. McNally, William Sheffler, T. J. Brunette, Derrick R. Hicks, Tomos E. Morgan, Tim J. Stevens, Adam Broerman, Inna Goreshnik, Michelle DeWitt, Cameron M. Chow, Yihang Shen, Lance Stewart, Emmanuel Derivery, Daniel Adriano Silva, Gira Bhabha, Damian C. Ekiert, David Baker
Publikováno v:
Nature. 616:581-589
General approaches for designing sequence-specific peptide-binding proteins would have wide utility in proteomics and synthetic biology. However, designing peptide-binding proteins is challenging, as most peptides do not have defined structures in is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bfb531fd20eb4be08615c8e33d81d2
https://doi.org/10.1038/s41586-023-05909-9
https://doi.org/10.1038/s41586-023-05909-9
Autor:
Andy Hsien-Wei Yeh, Christoffer Norn, Yakov Kipnis, Doug Tischer, Samuel J. Pellock, Declan Evans, Pengchen Ma, Gyu Rie Lee, Jason Z. Zhang, Ivan Anishchenko, Brian Coventry, Longxing Cao, Justas Dauparas, Samer Halabiya, Michelle DeWitt, Lauren Carter, K. N. Houk, David Baker
Publikováno v:
Nature, vol 614, iss 7949
De novo enzyme design has sought to introduce active sites and substrate-binding pockets that are predicted to catalyse a reaction of interest into geometrically compatible native scaffolds1,2, but has been limited by a lack of suitable protein struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdc44144c91254ef60302cb67f64229
https://doi.org/10.1038/s41586-023-05696-3
https://doi.org/10.1038/s41586-023-05696-3
Autor:
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D. DeBouver, Allison Pires, Asim K. Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance Stewart, Ian A. Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N. Savvides, K. Christopher Garcia, David Baker
Publikováno v:
NATURE
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab523f5e18cc78b7c277b545d214fda8
https://doi.org/10.1038/s41586-022-04654-9
https://doi.org/10.1038/s41586-022-04654-9
Autor:
Kejia Wu, Hua Bai, Ya-Ting Chang, Rachel Redler, Kerrie E. McNally, William Sheffler, TJ Brunette, Derrick R. Hicks, Tomos E Morgan, Tim J Stevens, Adam Broerman, Inna Goreshnik, Michelle DeWitt, Cameron M. Chow, Yihang Shen, Lance Stewart, Emmanuel Derivery, Daniel Adriano Silva, Gira Bhabha, Damian Ekiert, David Baker
General approaches for designing sequence-specific peptide binding proteins would have wide utility in proteomics and synthetic biology. Although considerable progress has been made in designing proteins which bind to other proteins, the general pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7fff23e15bdae13920e1136bfa6c20
https://doi.org/10.1101/2022.11.14.514089
https://doi.org/10.1101/2022.11.14.514089
Autor:
Jason Z. Zhang, Hsien-Wei Yeh, Alexandra C. Walls, Basile I. M. Wicky, Kaitlin R. Sprouse, Laura A. VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N. Pham, John C. Kraft, Ian C. Haydon, Wei Yang, Michelle DeWitt, John E. Bowen, Cameron M. Chow, Lauren Carter, Rashmi Ravichandran, Mark H. Wener, Lance Stewart, David Veesler, Michael S. Diamond, Alexander L. Greninger, David M. Koelle, David Baker
Publikováno v:
Nature biotechnology, vol 40, iss 9
We designed a protein biosensor that uses thermodynamic coupling for sensitive and rapid detection of neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in serum. The biosensor is a switchable, caged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458cd9dfec1e4f5632dd9fdbf5b270ba
https://escholarship.org/uc/item/1b11v74r
https://escholarship.org/uc/item/1b11v74r
Autor:
Derrick R. Hicks, Madison A. Kennedy, Kirsten A. Thompson, Michelle DeWitt, Brian Coventry, Alex Kang, Asim K. Bera, T. J. Brunette, Banumathi Sankaran, Barry Stoddard, David Baker
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(30)
Function follows form in biology, and the binding of small molecules requires proteins with pockets that match the shape of the ligand. For design of binding to symmetric ligands, protein homo-oligomers with matching symmetry are advantageous as each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdd3a21b35c0a040a9945d48a9efadc
https://pubmed.ncbi.nlm.nih.gov/35862457
https://pubmed.ncbi.nlm.nih.gov/35862457
Autor:
Iva Marković, Lisa Kozodoy, Wei Yang, K. Christopher Garcia, Joon Sung Park, K. Verschueren, Samer Halabiya, Lance Stewart, Ashish Phal, Lauren Miller, Rameshwar U. Kadam, Kevin Jude, Nathaniel Bennett, Savvas N. Savvides, Steffen Benard, Brian Coventry, Lora Picton, Aerin Yang, Inna Goreshnik, David Baker, Hannele Ruohola-Baker, Kenneth Verstraete, Joseph Schlessinger, Longxing Cao, Scott T. R. Walsh, Bradley Hammerson, Michelle DeWitt, Buwei Huang, Sangwon Lee, Eva-Maria Strauch, Ian A. Wilson
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains an outstanding challenge. We describe a general solution to this problem whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e1c6f76f3ac461c48924b0145081c91
https://doi.org/10.1101/2021.09.04.459002
https://doi.org/10.1101/2021.09.04.459002
Publikováno v:
Neurosurgery. 66:310-360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b49077e2bfe3a4c074b4c881ca0d0647
https://doi.org/10.1093/neuros/nyz310_360
https://doi.org/10.1093/neuros/nyz310_360