Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michelle D. Valero"'
Autor:
Eva Andres-Mateos, Lukas D. Landegger, Carmen Unzu, Jean Phillips, Brian M. Lin, Nicholas A. Dewyer, Julio Sanmiguel, Fotini Nicolaou, Michelle D. Valero, Kathrin I. Bourdeu, William F. Sewell, Rudolph J. Beiler, Michael J. McKenna, Konstantina M. Stankovic, Luk H. Vandenberghe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Gene therapy using Adeno-associated viral vectors (AAV) rescues hearing and balance deficits in mouse models of human disorders. Here, the authors show that AAVAnc80L65 allows efficient cochlear gene transfer in nonhuman primates, and motivate future
Externí odkaz:
https://doaj.org/article/7e6b7c587b2a4cc9b15c510a61c21f79
Autor:
Ann E. Hickox, Michelle D. Valero, James T. McLaughlin, Gregory S. Robinson, Jennifer A. Wellman, Michael J. McKenna, William F. Sewell, Emmanuel J. Simons
Publikováno v:
Journal of the American Academy of Audiology. 32:646-653
Millions of people worldwide have disabling hearing loss because one of their genes generates an incorrect version of some specific protein the ear requires for hearing. In many of these cases, delivering the correct version of the gene to a specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e399acdcbceafa670c5c33c4570022b
https://doi.org/10.1055/s-0041-1730410
https://doi.org/10.1055/s-0041-1730410
Publikováno v:
The Journal of the Acoustical Society of America. 146:3770-3789
Exposure to prolonged or high intensity noise increases the risk for permanent hearing impairment. Over several decades, researchers characterized the nature of harmful noise exposures and worked to establish guidelines for effective protection. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8843b31254eecd922f81953b2305f8
https://doi.org/10.1121/1.5132709
https://doi.org/10.1121/1.5132709
Autor:
Carolina Abdala, Michelle D Valero, Sebastiaan W F Meenderink, M. Charles Liberman, Christopher A. Shera
Publikováno v:
J Assoc Res Otolaryngol
Although anatomical development of the cochlear duct is thought to be complete by term birth, human newborns continue to show postnatal immaturities in functional measures such as otoacoustic emissions (OAEs). Some of these OAE immaturities are no do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbefd010194af1562cd00162e9aeb27
https://doi.org/10.1007/s10162-019-00734-2
https://doi.org/10.1007/s10162-019-00734-2
Autor:
Eva, Andres-Mateos, Lukas D, Landegger, Carmen, Unzu, Jean, Phillips, Brian M, Lin, Nicholas A, Dewyer, Julio, Sanmiguel, Fotini, Nicolaou, Michelle D, Valero, Kathrin I, Bourdeu, William F, Sewell, Rudolph J, Beiler, Michael J, McKenna, Konstantina M, Stankovic, Luk H, Vandenberghe
Publikováno v:
Nature communications. 13(1)
Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate hearing and balance disorders. We previously established the benefits of Anc80L65 in targeting inner and outer hair cells in newborn mice. To accelerate translati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5127349824b0acb8c0d0a1b7ffa8172
https://pubmed.ncbi.nlm.nih.gov/35292639
https://pubmed.ncbi.nlm.nih.gov/35292639
Publikováno v:
Hearing Research. 363:109-118
Cochlear synaptopathy, i.e. the loss of auditory-nerve connections with cochlear hair cells, is seen in aging, noise damage, and other types of acquired sensorineural hearing loss. Because the subset of auditory-nerve fibers with high thresholds and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc409b21835f563b5b721cce004fbe8b
https://doi.org/10.1016/j.heares.2018.03.012
https://doi.org/10.1016/j.heares.2018.03.012
Publikováno v:
Hearing Research. 332:29-38
Cochlear neuropathy, i.e. the loss of auditory nerve fibers (ANFs) without loss of hair cells, may cause hearing deficits without affecting threshold sensitivity, particularly if the subset of ANFs with high thresholds and low spontaneous rates (SRs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca4deda12a7aa393e5e58d507218d8c
https://doi.org/10.1016/j.heares.2015.11.005
https://doi.org/10.1016/j.heares.2015.11.005
Autor:
M.C. Liberman, Ramnarayan Ramachandran, S.N. Hauser, Troy A. Hackett, Jane A. Burton, Michelle D. Valero
Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in mice can destroy up to ∼50% of synapses between auditory nerve fibers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f53652c5250976eb461449e22d6bd25
https://europepmc.org/articles/PMC5632522/
https://europepmc.org/articles/PMC5632522/
Autor:
Michelle D. Valero, Rama Ratnam
Publikováno v:
Hearing Research. 282:265-271
This study examines the test-retest reliability of distortion-product otoacoustic emissions (DPOAEs) in ketamine-anesthetized common marmosets (Callithrix jacchus). DPOAE gain functions were measured at 16 f2-frequencies between 3 and 24 kHz. Test-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a479d1fdc6c14bdc8b305b4c52aa801
https://doi.org/10.1016/j.heares.2011.07.004
https://doi.org/10.1016/j.heares.2011.07.004
Publikováno v:
Hormones and Behavior. 55:98-105
Otoacoustic emissions (OAEs) were measured in male and female Suffolk sheep (Ovis aries). Some sheep had been administered androgens or estrogens during prenatal development, some were gonadectomized after birth, and some were allowed to develop norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc5bdccb5d0caa38f72d7c7d841b55a
https://doi.org/10.1016/j.yhbeh.2008.08.013
https://doi.org/10.1016/j.yhbeh.2008.08.013