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Autor:
Anuja Shah, Chan K. N. K. Chion, Rens de Groot, David A. Lane, James T. B. Crawley, Michelle D. Gardner
Publikováno v:
Blood. 113(5)
ADAMTS13 regulates the multimeric size of von Willebrand factor (VWF). Its function is highly dependent upon Ca2+ ions. Using the initial rates of substrate (VWF115, VWF residues 1554-1668) proteolysis by ADAMTS13 preincubated with varying Ca2+ conce