Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michelle D. Armstrong"'
Autor:
D.Lee Gorden, David S. Myers, Pavlina T. Ivanova, Eoin Fahy, Mano R. Maurya, Shakti Gupta, Jun Min, Nathanael J. Spann, Jeffrey G. McDonald, Samuel L. Kelly, Jingjing Duan, M.Cameron Sullards, Thomas J. Leiker, Robert M. Barkley, Oswald Quehenberger, Aaron M. Armando, Stephen B. Milne, Thomas P. Mathews, Michelle D. Armstrong, Chijun Li, Willie V. Melvin, Ronald H. Clements, M.Kay Washington, Alisha M. Mendonsa, Joseph L. Witztum, Ziqiang Guan, Christopher K. Glass, Robert C. Murphy, Edward A. Dennis, Alfred H. Merrill, Jr., David W. Russell, Shankar Subramaniam, H.Alex Brown
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 722-736 (2015)
The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different stages, particularly NASH, is important for both potential reversibil
Externí odkaz:
https://doaj.org/article/5355a334d12e40fda22b2a610c1de49b
Autor:
Keri A. Tallman, Michelle D. Armstrong, Stephen B. Milne, Lawrence J. Marnett, H. Alex Brown, Ned A. Porter
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 859-868 (2013)
Monitoring lipid distribution and metabolism in cells and biological fluids poses many challenges because of the many molecular species and metabolic pathways that exist. This study describes the synthesis and study of molecules that contain an alkyn
Externí odkaz:
https://doaj.org/article/550ad9f7e7b045629b537255a4a13e76
Autor:
Michelle D. Armstrong, H. Alex Brown, Keri A. Tallman, Ned A. Porter, Lawrence J. Marnett, Stephen B. Milne
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 859-868 (2013)
Monitoring lipid distribution and metabolism in cells and biological fluids poses many challenges because of the many molecular species and metabolic pathways that exist. This study describes the synthesis and study of molecules that contain an alkyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12dbb62f152f6e608c79a9945c447260
http://www.sciencedirect.com/science/article/pii/S0022227520419509
http://www.sciencedirect.com/science/article/pii/S0022227520419509
Autor:
Jana A. Lewis, H. Alex Brown, Paige E. Selvy, Robert R. Lavieri, Sarah A. Scott, Craig W. Lindsley, Michelle D. Armstrong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2240-2243
This Letter describes the synthesis and structure-activity relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of a 1,3,8-triazaspiro[4,5]decan-4-one privileged structure, PLD inhibitors with nanomolar potency and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e54e68e073c7ddcafb5251cd929809e
https://doi.org/10.1016/j.bmcl.2009.02.125
https://doi.org/10.1016/j.bmcl.2009.02.125
Autor:
Robert R. Lavieri, Jana A. Lewis, Paige E. Selvy, Michelle D. Armstrong, Jason R. Buck, Craig W. Lindsley, H. Alex Brown, Sydney L. Stoops, Sarah A. Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1916-1920
This Letter describes the synthesis and structure-activity-relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of alternative halogenated piperidinyl benzimidazolone privileged structures, in combination with a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6825f7944ffc4a46c8fc4bb195842ab7
https://doi.org/10.1016/j.bmcl.2009.02.057
https://doi.org/10.1016/j.bmcl.2009.02.057
Autor:
Michelle D. Armstrong, Matthew K. Topham, H. Alex Brown, Yulia V. Shulga, Stephen B. Milne, Jovana Lubarda, David S. Myers, Richard M. Epand, Pavlina T. Ivanova
Publikováno v:
Biochemistry. 47:9372-9379
Lipid species changes for SV40-transformed fibroblasts from wild-type or from diacylglycerol kinase-epsilon (DGKepsilon) or diacylglycerol kinase-alpha (DGKalpha) knockout mice were determined for glycerophospholipids, polyphosphatidylinositides (GPI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af82e887f45e5b6f0f1dd89c7c697372
https://doi.org/10.1021/bi800492c
https://doi.org/10.1021/bi800492c
Autor:
Heather A. Brown, Michelle D. Armstrong, Ying Fang, Yu Sun, Marta Roccio, F. J. Zwartkruis, Chongben Zhang, Jiawen Chen, Mee-Sup Yoon
Publikováno v:
Proceedings of the National Academy of Sciences. 105:8286-8291
The mammalian target of rapamycin (mTOR) assembles a signaling network essential for the regulation of cell growth, which has emerged as a major target of anticancer therapies. The tuberous sclerosis complex 1 and 2 (TSC1/2) proteins and their target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c85c861c7f665b8d6181aa07024e24
https://doi.org/10.1073/pnas.0712268105
https://doi.org/10.1073/pnas.0712268105
Autor:
Michelle D. Armstrong, Alfred H. Merrill, Aaron M. Armando, Jingjing Duan, Shankar Subramaniam, Edward A. Dennis, Joseph L. Witztum, Stephen B. Milne, Nathanael J. Spann, Chijun Li, M. Kay Washington, Thomas P. Mathews, Jun Min, Shakti Gupta, Ronald H. Clements, Eoin Fahy, David W. Russell, M. Cameron Sullards, Mano Ram Maurya, D. Lee Gorden, Robert M. Barkley, Willie Melvin, David S. Myers, Ziqiang Guan, H. Alex Brown, Robert C. Murphy, Thomas J. Leiker, Oswald Quehenberger, Pavlina T. Ivanova, Jeffrey G. McDonald, Christopher K. Glass, Alisha M. Mendonsa, Samuel Kelly
Publikováno v:
Journal of lipid research, vol 56, iss 3
The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different stages, particularly NASH, is important for both potential reversibil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c6c012d2c1e66caacbe446bcc36818
https://escholarship.org/uc/item/7c6459vf
https://escholarship.org/uc/item/7c6459vf
Autor:
H. Alex Brown, Ned A. Porter, Michelle D. Armstrong, Charles M. Lukehart, Lawrence J. Marnett, Stephen B. Milne, Keri A. Tallman, Carol A. Rouzer, Remigiusz A. Serwa
Publikováno v:
Nature chemical biology
Alkyne-modified phospholipids can be unambiguously identified and differentiated from native species in complex mixtures by formation of dicobalthexacarbonyl complexes. This reaction is specific for alkynes and is unaffected by other glycerophospholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6929d3990cf1b859685d74230be9401b
http://europepmc.org/articles/PMC2822082
http://europepmc.org/articles/PMC2822082
Autor:
H. Alex Brown, David S. Myers, Yun Xiang, Michelle D. Armstrong, Craig W. Lindsley, Matthew C. O’Reilly, Keri A. Tallman, Sarah A. Scott, Thomas P. Mathews, Hyekyung P. Cho
Phosphatidic acid (PA) is a lipid second messenger located at the intersection of several lipid metabolism and cell signaling events including membrane trafficking, survival, and proliferation. Generation of signaling PA has long been primarily attri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61af733b3d7f49f32db3c2c390f1ca4a
https://europepmc.org/articles/PMC3711313/
https://europepmc.org/articles/PMC3711313/