Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Michelle D Wang"'
Autor:
Ming Li, Arjan Hada, Payel Sen, Lola Olufemi, Michael A Hall, Benjamin Y Smith, Scott Forth, Jeffrey N McKnight, Ashok Patel, Gregory D Bowman, Blaine Bartholomew, Michelle D Wang
Publikováno v:
eLife, Vol 4 (2015)
The chromatin landscape and promoter architecture are dominated by the interplay of nucleosome and transcription factor (TF) binding to crucial DNA sequence elements. However, it remains unclear whether nucleosomes mobilized by chromatin remodelers c
Externí odkaz:
https://doaj.org/article/0a3121e451094716ba70279f42022f86
Publikováno v:
eLife, Vol 2 (2013)
Single-molecule experiments have shed new light on the mechanisms responsible for the movement of RNA polymerase along DNA during transcription.
Externí odkaz:
https://doaj.org/article/dac092ba484646ff973959c5052a061b
Autor:
Lucy D Brennan, Thibault Roland, Diane G Morton, Shanna M Fellman, SueYeon Chung, Mohammad Soltani, Joshua W Kevek, Paul M McEuen, Kenneth J Kemphues, Michelle D Wang
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75712 (2013)
The introduction of chemical inhibitors into living cells at specific times in development is a useful method for investigating the roles of specific proteins or cytoskeletal components in developmental processes. Some embryos, such as those of Caeno
Externí odkaz:
https://doaj.org/article/703027dda1924cc7a745df32a6ea72fb
Autor:
Lijuan Guo, Yanling Bao, Yilin Zhao, Zhiyun Ren, Lulu Bi, Xia Zhang, Cong Liu, Xi‐Miao Hou, Michelle D. Wang, Bo Sun
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract G‐quadruplex (G4) is a four‐stranded noncanonical DNA structure that has long been recognized as a potential hindrance to DNA replication. However, how replisomes effectively deal with G4s to avoid replication failure is still obscure. H
Externí odkaz:
https://doaj.org/article/59fedc9098a54bf2979991b8d01b43c4
Autor:
Jaeyoon Lee, Meiling Wu, James T. Inman, Gundeep Singh, Seong ha Park, Joyce H. Lee, Robert M. Fulbright, Yifeng Hong, Joshua Jeong, James M. Berger, Michelle D. Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Type IIA topoisomerases are essential DNA processing enzymes that must robustly and reliably relax DNA torsional stress. While cellular processes constantly create varying torsional stress, how this variation impacts type IIA topoisomerase f
Externí odkaz:
https://doaj.org/article/7a8972e296dc4f92b3995bcbecc92cce
Autor:
Tung T. Le, Meiling Wu, Joyce H. Lee, Neti Bhatt, James T. Inman, James M. Berger, Michelle D. Wang
Publikováno v:
Nature Chemical Biology. 19:641-650
Etoposide is a broadly employed chemotherapeutic and eukaryotic topoisomerase II poison that stabilizes cleaved DNA intermediates to promote DNA breakage and cytotoxicity. How etoposide perturbs topoisomerase dynamics is not known. Here we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84bc1449e55d9a15e27491ac038c1759
https://doi.org/10.1038/s41589-022-01235-9
https://doi.org/10.1038/s41589-022-01235-9
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2478
Angular optical trapping (AOT) is a powerful technique that permits direct angular manipulation of a trapped particle with simultaneous measurement of torque and rotation, while also retaining the capabilities of position and force detection. This te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fcd90a8d68e8a1917cff6049490b951
https://pubmed.ncbi.nlm.nih.gov/36063318
https://pubmed.ncbi.nlm.nih.gov/36063318
Autor:
Ryan P. Badman, Jessica L. Killian, Michelle D. Wang, Fenghua Hu, Tuancheng Feng, Shanna Moore, Thomas A. Cleland
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Recent technological advances have introduced diverse engineered nanoparticles (ENPs) into our air, water, medicine, cosmetics, clothing, and food. However, the health and environmental effects of these increasingly common ENPs are still not well und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59943bd3dfd9c5429976a0d7b80fc3a
http://link.springer.com/article/10.1038/s41598-020-67724-w
http://link.springer.com/article/10.1038/s41598-020-67724-w
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Nanophotonic tweezers represent emerging platforms with significant potential for parallel manipulation and measurements of single biological molecules on-chip. However, trapping force generation represents a substantial obstacle for their broader ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5748b0380185fb4f8926e294f090183
https://doi.org/10.1038/s41467-021-27709-3
https://doi.org/10.1038/s41467-021-27709-3
Autor:
Porter M. Hall, James T. Inman, Robert M. Fulbright, Tung T. Le, Joshua J. Brewer, Guillaume Lambert, Seth A. Darst, Michelle D. Wang
Publikováno v:
Biophysical Journal. 122:71a
CRISPR (clustered regularly interspaced short palindromic repeats) utility relies on a stable Cas effector complex binding to its target site. However, a Cas complex bound to DNA may be removed by motor proteins carrying out host processes and the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440e84c82123a963078abe88944d8bfc
https://doi.org/10.1016/j.bpj.2022.11.592
https://doi.org/10.1016/j.bpj.2022.11.592