Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michelle D Cully"'
Autor:
Peter J. Siska, Jing Jiao, Carina Matos, Katrin Singer, Raffaela S. Berger, Katja Dettmer, Peter J. Oefner, Michelle D. Cully, Zhonglin Wang, William J. QuinnIII, Kristen N. Oliff, Benjamin J. Wilkins, Lanette M. Christensen, Liqing Wang, Wayne W. Hancock, Joseph A. Baur, Matthew H. Levine, Ines Ugele, Roman Mayr, Kathrin Renner, Liang Zhou, Marina Kreutz, Ulf H. Beier
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103734- (2021)
Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce le
Externí odkaz:
https://doaj.org/article/707b3408191f474680381251d1043115
Autor:
William J. Quinn, III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108500- (2020)
Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effe
Externí odkaz:
https://doaj.org/article/7bafd43031934dc89425250de8164ad0
Autor:
Michelle D Cully, Yinling Hu, Michael P. Cancro, Nipun Jayachandran, Ellen Puré, Michael J. May, Bruce D. Freedman, Jorge I. Alvarez, James Monslow, Jacquelyn Freund-Brown, Kelly A. McCorkell, Tiffany Weinkopff
Publikováno v:
Proc Natl Acad Sci U S A
Global inactivation of IκB kinase (IKK)-α results in defective lymph node (LN) formation and B cell maturation, and loss of IKK-α–dependent noncanonical NF-κB signaling in stromal organizer and hematopoietic cells is thought to underlie these d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e0273640f68b217d3db0ba0668cb0c
https://pubmed.ncbi.nlm.nih.gov/34810256
https://pubmed.ncbi.nlm.nih.gov/34810256
Autor:
Jason Hataye, Zhi Yong Yang, Nicole A. Doria-Rose, John R. Mascola, Giulia Fabozzi, Hui Li, Tongqing Zhou, Wei Shi, Kylie March, Brandon F. Keele, George M. Shaw, Joseph P. Casazza, Kathryn E. Foulds, Joana Dias, Wanwisa Promsote, Gary J. Nabel, Michelle D. Cully, Richard A. Koup, Xuejun Chen, Amarendra Pegu, Ling Xu, Ronnie Wei, Hui Geng, Cuiping Liu, Amy Noe, Jeffrey D. Lifson, Cassandra G. Almasri, Ercole Rao, Constantinos Petrovas, Mangaiarkarasi Asokan, John-Paul Todd, Krisha McKee, Christine M. Fennessey, Stephen D. Schmidt, Eun Sung Yang, Megan E. DeMouth, Keyun Wang, Shing-Fen Kao
Publikováno v:
SSRN Electronic Journal.
Broadly neutralizing antibodies (bNAbs) represent an alternative to drug therapy for the treatment of HIV-1 infection. Immunotherapy with single bNAbs often leads to emergence of escape variants, suggesting a potential benefit of combination bNAb the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f6b7386946023da5604ae4184a50c8d
https://doi.org/10.2139/ssrn.3898083
https://doi.org/10.2139/ssrn.3898083
Autor:
Amarendra Pegu, Ling Xu, Megan E. DeMouth, Giulia Fabozzi, Kylie March, Cassandra G. Almasri, Michelle D. Cully, Keyun Wang, Eun Sung Yang, Joana Dias, Christine M. Fennessey, Jason Hataye, Ronnie R. Wei, Ercole Rao, Joseph P. Casazza, Wanwisa Promsote, Mangaiarkarasi Asokan, Krisha McKee, Stephen D. Schmidt, Xuejun Chen, Cuiping Liu, Wei Shi, Hui Geng, Kathryn E. Foulds, Shing-Fen Kao, Amy Noe, Hui Li, George M. Shaw, Tongqing Zhou, Constantinos Petrovas, John-Paul Todd, Brandon F. Keele, Jeffrey D. Lifson, Nicole A. Doria-Rose, Richard A. Koup, Zhi-yong Yang, Gary J. Nabel, John R. Mascola
Publikováno v:
Cell Rep
Broadly neutralizing antibodies (bNAbs) represent an alternative to drug therapy for the treatment of HIV-1 infection. Immunotherapy with single bNAbs often leads to emergence of escape variants, suggesting a potential benefit of combination bNAb the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ebfd10b096d3ff53100dbc4cb8cee3
https://doi.org/10.1016/j.celrep.2021.110199
https://doi.org/10.1016/j.celrep.2021.110199
Autor:
Dennis R. Burton, Amarendra Pegu, Yunda Huang, Peter B. Gilbert, Stephen D. Schmidt, Ann J. Hessell, Nancy L. Haigwood, Matthias Pauthner, John R. Mascola, George M. Shaw, Ying Huang, Bhavesh Borate, Nicole A. Doria-Rose, Mario Roederer, Michelle D. Cully, Xuejun Chen, Boris Julg, Dan H. Barouch, Lawrence Corey, Lindsay N. Carpp
Publikováno v:
Cell Host Microbe
Passively administered broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have been shown to protect non-human primates (NHPs) against chimeric simian-human immunodeficiency virus (SHIV) infection. With data from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eed3d98ce45623f55b40124e32554db
https://pubmed.ncbi.nlm.nih.gov/31513771
https://pubmed.ncbi.nlm.nih.gov/31513771
Autor:
Wayne W. Hancock, Ulf H. Beier, Louis R. Ghanem, Caroline Perry, Alessia Angelin, Ian A. Blair, Matthew H. Levine, Michelle D. Cully, Piotr K. Kopinski, Joseph A. Baur, William J. Quinn, Douglas C. Wallace, Edmund K. Moon, Liqing Wang, Michael S. Leibowitz, Jason Stadanlick, Zhonglin Wang, Patrick M. Schäfer, Tara TeSlaa, Lili Guo, Jing Jiao, Evgeniy Eruslanov, Tatiana Akimova
Publikováno v:
Cell reports
Cell Reports, Vol 33, Iss 11, Pp 108500-(2020)
Cell Reports, Vol 33, Iss 11, Pp 108500-(2020)
SUMMARY Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be55d6ee0c97cfe87cd68c3efb405b66
http://europepmc.org/articles/PMC7830708
http://europepmc.org/articles/PMC7830708
Autor:
Ema T. Crooks, Nicole A. Doria-Rose, John R. Mascola, Ben Murrell, Evan M. Cale, Barton F. Haynes, Amarendra Pegu, Gillian Dekkers, James M. Binley, Gestur Vidarsson, Sebastian Rämisch, William R. Schief, Kevin O. Saunders, Samantha L. Grimley, Keiko Osawa, Sergey Menis, Michelle D. Cully
Publikováno v:
PLoS Pathogens
PLoS pathogens, 14(5):e1007024. Public Library of Science
PLoS Pathogens, Vol 14, Iss 5, p e1007024 (2018)
PLoS pathogens, 14(5):e1007024. Public Library of Science
PLoS Pathogens, Vol 14, Iss 5, p e1007024 (2018)
The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and avoid clashes with othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b1562cab2eddb650c6e30824eacd5d
https://doi.org/10.1371/journal.ppat.1007024
https://doi.org/10.1371/journal.ppat.1007024