Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michelle Couzens"'
Autor:
Katy Slack, Ronaldo F. Enriquez, Herbert Herzog, Nicola J. Lee, Ross J. Bland, Matthew J. During, Dana Boey, Amanda Sainsbury, Michelle Couzens, En-Ju D. Lin
Publikováno v:
Endocrinology. 147:5094-5101
Neuropeptide Y (NPY) is a key regulator of energy homeostasis and is implicated in the development of obesity and type 2 diabetes. Whereas it is known that hypothalamic administration of exogenous NPY peptides leads to increased body weight gain, hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbd2e4bf44c1f9a57c38f20b11b9f28
https://doi.org/10.1210/en.2006-0097
https://doi.org/10.1210/en.2006-0097
Autor:
Dana Boey, Ronaldo F. Enriquez, Edith M. Gardiner, Amanda Sainsbury, Susan J. Allison, En-Ju D. Lin, Matthew J. During, Michelle Couzens, Paul A. Baldock, Herbert Herzog
Publikováno v:
Journal of Bone and Mineral Research. 20:1851-1857
Leptin and Y2 receptors on hypothalamic NPY neurons mediate leptin effects on energy homeostasis; however, their interaction in modulating osteoblast activity is not established. Here, direct testing of this possibility indicates distinct mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07e60935b76ace7477e0abfc9eb90bd
https://doi.org/10.1359/jbmr.050523
https://doi.org/10.1359/jbmr.050523
Autor:
Helen M. Cox, Amanda Sainsbury, Sergueï O. Fetissov, Tomas Hökfelt, Christoph Schwarzer, Michelle Couzens, Arthur B. Jenkins, Günther Sperk, Sabine Furtinger, Herbert Herzog
Publikováno v:
Proceedings of the National Academy of Sciences. 99:8938-8943
Neuropeptide Y is implicated in energy homeostasis, and contributes to obesity when hypothalamic levels remain chronically elevated. To investigate the specific role of hypothalamic Y2 receptors in this process, we used a conditional Y2 knockout mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32586470e038046ed05440c0548cfb40
https://doi.org/10.1073/pnas.132043299
https://doi.org/10.1073/pnas.132043299
Autor:
Helmut Klocker, Camilla Tüchler, Barbara Kofler, Marjorie Liu, Rachel M. C. Parker, Michelle Couzens, Claudia Nessler-Menardi, Herbert Herzog
Publikováno v:
Genomics. 64:318-323
Several gene duplication events have led to the creation of at least five distinct members of the neuropeptide Y gene family. We now reveal that the most recent of these events, involving the PYY-PPY gene cluster on chromosome 17q21.1, has led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431d57457185dbf098b2616b60d7d9d1
https://doi.org/10.1006/geno.2000.6132
https://doi.org/10.1006/geno.2000.6132
Autor:
Kerry A. Nichol, Adrienne Morey, John Shine, Michelle Couzens, Herbert Herzog, Anne M. Cunningham
Publikováno v:
The Journal of Neuroscience. 19:10295-10304
Neuropeptide Y receptors belong to the G-protein-coupled receptor superfamily and mediate a wide variety of physiological functions, including blood pressure regulation, hormone release, appetite control, seizure propensity, cognition, and emotion. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a594b43b16e0a0bbebfa84e0880e2d4c
https://doi.org/10.1523/jneurosci.19-23-10295.1999
https://doi.org/10.1523/jneurosci.19-23-10295.1999
Publikováno v:
Pesticide Science. 36:247-253
Novel 5‐amino‐1‐phenylpyrazol‐4‐yl alkyl ketones were synthesised and their herbicidal properties evaluated. Active compounds in the series induced accumulation of protoporphyrin IX in etiolated cucumber cotyledons and caused light‐depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a5c21b0551bcbcb50a23df3bf6abd35
https://doi.org/10.1002/ps.2780360311
https://doi.org/10.1002/ps.2780360311
Autor:
Ronaldo F. Enriquez, Amanda Sainsbury, Nicola J. Lee, Paul A. Baldock, Katy Slack, Herbert Herzog, Shu Lin, Dana Boey, Michelle Couzens
The gut-derived hormone, peptide YY (PYY) reduces food intake and enhances satiety in both humans and animals. Obese individuals also have a deficiency in circulating peptide YY, although whether this is a cause or a consequence of obesity is unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64ce7d2e97c97fbbf0d9429db5b3c24
Autor:
Katy Slack, Amanda Sainsbury, Keely McNamara, Michelle Couzens, George A. Smythe, Christoph Schwarzer, Dana Boey, Tim Karl, Nicola J. Lee, Ronaldo F. Enriquez, En-Ju D. Lin, Shu Lin, Herbert Herzog, Paul A. Baldock
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 21(7)
Endogenous opioids, particularly dynorphins, have been implicated in regulation of energy balance, but it is not known how they mediate this in vivo. We investigated energy homeostasis in dynorphin knockout mice (Dyn−/− mice) and probed the inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad9918aee83bb615bfdab7a35f4cc75
https://pubmed.ncbi.nlm.nih.gov/17456788
https://pubmed.ncbi.nlm.nih.gov/17456788
Autor:
Katy Slack, Michelle Couzens, Shu Lin, Robert Dallmann, Paul A. Baldock, Herbert Herzog, Ronaldo F. Enriquez, Dana Boey, Amanda Sainsbury, Tim Karl, Nicola J. Lee
Obese people exhibit reduced circulating peptide YY (PYY) levels, but it is unclear whether this is a consequence or cause of obesity. We therefore investigated the effect of Pyy ablation on energy homeostasis.Body composition, i.p. glucose tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f154377984281ebe16a2edf6e6755fe
https://hdl.handle.net/2123/16159
https://hdl.handle.net/2123/16159
Autor:
Tim Karl, Nicola J. Lee, Nikolas Stroth, Katy Slack, Ronaldo F. Enriquez, Diana Lindner, Liesl Duffy, Gregory J. Cooney, Michelle Couzens, Günther Sperk, Amanda Sainsbury, Herbert Herzog, Darja Bamming, Hugo Bergen, Nicolas Singewald, Shu Lin, Dana Boey
Neuropeptide Y receptors are critical regulators of energy homeostasis, but the functional interactions and relative contributions of Y receptors and the environment in this process are unknown. We measured the effects of an ad libitum diet of normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9152260cec50cae167ad52e4ad3fb47
https://hdl.handle.net/2123/16171
https://hdl.handle.net/2123/16171