Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michelle Clasquin"'
Autor:
Eliza Bollinger, Matthew Peloquin, Jenna Libera, Bina Albuquerque, Evanthia Pashos, Arun Shipstone, Angela Hadjipanayis, Zhongyuan Sun, Gang Xing, Michelle Clasquin, John C. Stansfield, Brendan Tierney, Steven Gernhardt, C. Parker Siddall, Timothy Greizer, Frank J. Geoly, Sarah R. Vargas, Lily C. Gao, George Williams, Mackenzie Marshall, Amy Rosado, Claire Steppan, Kevin J. Filipski, Bei B. Zhang, Russell A. Miller, Rachel J. Roth Flach
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101611- (2022)
Objective: Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how enhancing BCAA catabolism affected metabolic homeostasis as well as the mechanisms u
Externí odkaz:
https://doaj.org/article/e41f6bdec3ce4e71ab9ff32d257eaba6
Autor:
Shenping Liu, Ruth Sommese, Nicole Nedoma, Lucy Stevens, Jason Dutra, Yang Wang, Michelle Garnsey, Michelle Clasquin
Hydroxysteroid 17-beta-dehydrogenase 13 (HSD17B13) is a hepatic lipid droplet-associated enzyme that is upregulated in patients with non-alcoholic fatty liver disease. Recently, there have been several reports that predicted loss of function variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16af679c6cdd2c02c0f5f61fb6e48696
https://doi.org/10.21203/rs.3.rs-2688507/v1
https://doi.org/10.21203/rs.3.rs-2688507/v1
Autor:
Xincheng Xu, Tara TeSlaa, Gang Xing, Zhaoyue Zhang, Gregory J. Tesz, Xianfeng Zeng, Michelle Clasquin, Joshua D. Rabinowitz, Lifeng Yang
Publikováno v:
Nature Metabolism. 3:1608-1620
Carbohydrate can be converted into fat by de novo lipogenesis, a process upregulated in fatty liver disease. Chemically, de novo lipogenesis involves polymerization and reduction of acetyl-CoA, using NADPH as the electron donor. The feedstocks used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fce32433d8563beca2e40b43c9b99f2e
https://doi.org/10.1038/s42255-021-00487-4
https://doi.org/10.1038/s42255-021-00487-4
Autor:
David A. Beebe, Gregg D. Cappon, Michelle Clasquin, Marc K. Hellerstein, Norimitsu Shirai, William J. Reagan, Zhongyuan Sun, Katherine Hales, Gabriele E. Sonnenberg, Jeffrey A. Pfefferkorn, Theodore J. Schmahai, Nicholas B. Vera, Marcy Matthews, Trenton T. Ross, Clare Buckeridge, Enida Ziso Qejvanaj, Kenneth L. Kelly, Shoh Asano, Santos Carvajal-Gonzalez, William P. Esler, Paul A. Amor, Kelvin W. Li, Arthur Bergman
Publikováno v:
Nature Metabolism. 2:1163-1178
Acetyl-CoA carboxylase (ACC) catalyses the first step of de novo lipogenesis (DNL). Pharmacologic inhibition of ACC has been of interest for therapeutic intervention in a wide range of diseases. We demonstrate here that ACC and DNL are essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37212bb75eaf160e3e8857af5cd7c6c9
https://doi.org/10.1038/s42255-020-00272-9
https://doi.org/10.1038/s42255-020-00272-9
Autor:
Shengfang Jin, Stephen P. McCalley, Michelle Clasquin, David Pirman, Kendall Johnson, Jerry Vockley
Publikováno v:
Mol Genet Metab
Branched chain amino acid (BCAA) metabolism occurs within the mitochondrial matrix and is comprised of multiple enzymes, some shared, organized into three pathways for the catabolism of leucine, isoleucine, and valine (LEU, ILE, and VAL respectively)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7dde22b3b4d92329fe7faf85c238a8
https://doi.org/10.1016/j.ymgme.2019.05.008
https://doi.org/10.1016/j.ymgme.2019.05.008
Autor:
Michelle Clasquin, Nicholas B. Vera, Albert J. Fornace, Jeffrey A. Pfefferkorn, Paul Vouros, Christopher A. Barker, Evagelia C. Laiakis, Stephen L. Coy
Publikováno v:
J Am Soc Mass Spectrom
Acylcarnitines have been identified in human and animal metabolomic-profiling studies as urinary markers of radiation exposure, a result which is consistent with their cytoprotective effects and roles in energy metabolism. In the present work, a rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7c727819396c3ab9121fb2f81b9f46
https://europepmc.org/articles/PMC7489307/
https://europepmc.org/articles/PMC7489307/
Publikováno v:
Metabolites, Vol 11, Iss 772, p 772 (2021)
Metabolites
Volume 11
Issue 11
Metabolites
Volume 11
Issue 11
A key unmet need in metabolomics continues to be the specific, selective, accurate detection of traditionally difficult to retain molecules including simple sugars, sugar phosphates, carboxylic acids, and related amino acids. Designed to retain the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832c065f6b812f38ea09b071bff0526e
https://doi.org/10.3390/metabo11110772
https://doi.org/10.3390/metabo11110772
Autor:
Gabriele E. Sonnenberg, Collin Crowley, Trenton T. Ross, Michelle Clasquin, Arthur Bergman, Anu Nigam, Yan Weng, Derek M. Erion, Kou Kou, Morris J. Birnbaum, Gang Xing, Nicholas B. Vera, Kristin Chidsey, Veena Somayaji, William P. Esler, Jemy A. Gutierrez, Richard Allen, Kendra K. Bence, Jeffrey A. Pfefferkorn, Magee Thomas Victor, Sylvie Perez, Matt Blatnik, Gregory J. Tesz, Melissa A. Fulham, Wei Liu
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 48, Iss, Pp 101196-(2021)
Molecular Metabolism, Vol 48, Iss, Pp 101196-(2021)
Objective Recent studies suggest that excess dietary fructose contributes to metabolic dysfunction by promoting insulin resistance, de novo lipogenesis (DNL), and hepatic steatosis, thereby increasing the risk of obesity, type 2 diabetes (T2D), non-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9832276149b62b82c13f9550e053414
https://doi.org/10.1016/j.molmet.2021.101196
https://doi.org/10.1016/j.molmet.2021.101196
Publikováno v:
Methods in Molecular Biology ISBN: 9781071600290
Differential mobility spectrometry (DMS) is capable of separating molecules based on their size and shape. When coupled to mass spectrometry (MS), DMS reduces chemical background and enhances signal-to-noise (S/N) ratio. Flow injection analysis (FIA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::746d57f87d50345fd852f04c48cd69cc
https://doi.org/10.1007/978-1-0716-0030-6_5
https://doi.org/10.1007/978-1-0716-0030-6_5
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2084
Differential mobility spectrometry (DMS) is capable of separating molecules based on their size and shape. When coupled to mass spectrometry (MS), DMS reduces chemical background and enhances signal-to-noise (S/N) ratio. Flow injection analysis (FIA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81c6c06bbbd65dae3469d5cd452a6556
https://pubmed.ncbi.nlm.nih.gov/31729655
https://pubmed.ncbi.nlm.nih.gov/31729655