Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michelle C. Schaeffer"'
Autor:
Pamela A. Haile, Linda N. Casillas, Bartholomew J. Votta, Gren Z. Wang, Adam K. Charnley, Xiaoyang Dong, Michael J. Bury, Joseph J. Romano, John F. Mehlmann, Bryan W. King, Karl F. Erhard, Charles R. Hanning, David B. Lipshutz, Biva M. Desai, Carol A. Capriotti, Michelle C. Schaeffer, Scott B. Berger, Mukesh K. Mahajan, Michael A. Reilly, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, John K. Kenna, Allison M. Beal, Michael T. Ouellette, Mike Kelly, Gillian Stemp, Máire A. Convery, Anna Vossenkämper, Thomas T. MacDonald, Peter J. Gough, John Bertin, Robert W. Marquis
Publikováno v:
Journal of Medicinal Chemistry. 62:6482-6494
Autor:
Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
Publikováno v:
Journal of Medicinal Chemistry. 62:5096-5110
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have advanced into early clinical
Autor:
Xiaoyang Dong, Anna Vossenkämper, Attiq Rahman, Viera Kasparcova, Robert Singhaus, Joshua N. Finger, Bryan W. King, Patrick M. Eidam, Michael Reilly, David D. Wisnoski, Scott B. Berger, John D. Lich, James Kang, Michael T. Ouellette, Lauren Dare, Philip A. Harris, Julie A. Cox, Nathan A. Miller, John Bertin, Michelle C. Schaeffer, Deepak Bandyopadhyay, Daohua Zhang, Alan R. Rendina, Clark A. Sehon, Sandra J. Hoffman, Peter J. Gough, Rachel D. Totoritis, Thomas T. MacDonald, Yunfeng Lan, Paris Ward, Barbara A. Swift, Robert W. Marquis, Lara Kathryn Leister, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, Carol A. Capriotti, Nino Campobasso, Ruth Lehr, Christina S. Pao, Jae U. Jeong
Publikováno v:
Journal of Medicinal Chemistry. 60:1247-1261
RIP1 regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. Small-molecule inhibitors of RIP1 kinase that are suitable for advancement
Autor:
Pamela A, Haile, Linda N, Casillas, Bartholomew J, Votta, Gren Z, Wang, Adam K, Charnley, Xiaoyang, Dong, Michael J, Bury, Joseph J, Romano, John F, Mehlmann, Bryan W, King, Karl F, Erhard, Charles R, Hanning, David B, Lipshutz, Biva M, Desai, Carol A, Capriotti, Michelle C, Schaeffer, Scott B, Berger, Mukesh K, Mahajan, Michael A, Reilly, Rakesh, Nagilla, Elizabeth J, Rivera, Helen H, Sun, John K, Kenna, Allison M, Beal, Michael T, Ouellette, Mike, Kelly, Gillian, Stemp, Máire A, Convery, Anna, Vossenkämper, Thomas T, MacDonald, Peter J, Gough, John, Bertin, Robert W, Marquis
Publikováno v:
Journal of medicinal chemistry. 62(14)
RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. Small-molecule inhibitors of RIP2 kinase or its signaling partne
Autor:
Shunsuke Otani, Eileen M. Burd, Scott B. Berger, Craig M. Coopersmith, Kristal M. Maner-Smith, John Bertin, Sandra J. Hoffman, Alexandra DeLaney, Gregory K. Tharp, Michelle C. Schaeffer, Linda Roback, Carol A. Capriotti, Peter J. Gough, Cedrick Young, Steven E. Bosinger, Zhe Liang, Nelson C. DiPaolo, Edward S. Mocarski, Dmitry M. Shayakhmetov, Igor E. Brodsky, Yanjun Feng, Pratyusha Mandal, John D. Lyons, Eric A. Ortlund
Summary The execution of shock following high dose E. coli lipopolysaccharide (LPS) or bacterial sepsis in mice required pro-apoptotic caspase-8 in addition to pro-pyroptotic caspase-11 and gasdermin D. Hematopoietic cells produced MyD88- and TRIF-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fbdf244c275c03e848f8c2615710ce
https://europepmc.org/articles/PMC6064639/
https://europepmc.org/articles/PMC6064639/
Autor:
Barb Swift, Peter J. Gough, Michelle C. Schaeffer, Lauren Dare, Angela Hughes-Earle, Philip A. Harris, Carol A. Capriotti, William J. Kaiser, Edward S. Mocarski, Michael Cook, Sandy Hoffman, Viera Kasparcova, Scott B. Berger, Joshua N. Finger, John Bertin
Publikováno v:
The Journal of Immunology. 192:5476-5480
RIP1 (RIPK1) kinase is a key regulator of TNF-induced NF-κB activation, apoptosis, and necroptosis through its kinase and scaffolding activities. Dissecting the balance of RIP1 kinase activity and scaffolding function in vivo during development and
Autor:
Michelle C. Schaeffer, Peter J. Gough, James Kang, Viera Kasparcova, Jae U. Jeong, LaShadric C. Grady, Joshua N. Finger, Paris Ward, Daohua Zhang, Robert W. Marquis, Lauren Dare, Michael T. Ouellette, Deepak Bandyopadhyay, Rakesh Nagilla, Xiaoyang Dong, Carol A. Capriotti, Christina S. Pao, Nino Campobasso, Rachel D. Totoritis, Philip A. Harris, Ruth Lehr, Jennifer Summerfield, Bryan W. King, Ami S. Lakdawala, Julie A. Cox, Barbara A. Swift, Aming Zhang, Scott B. Berger, John Bertin, Dean E. McNulty, Alan R. Rendina, Sandra J. Hoffman
Publikováno v:
Journal of medicinal chemistry. 59(5)
The recent discovery of the role of receptor interacting protein 1 (RIP1) kinase in tumor necrosis factor (TNF)-mediated inflammation has led to its emergence as a highly promising target for the treatment of multiple inflammatory diseases. We screen
Autor:
Scott B. Berger, Robert W. Marquis, Rakesh Nagilla, John Bertin, Sandy Hoffman, Carol A. Capriotti, Michael T. Ouellette, Michelle C. Schaeffer, Julie A. Cox, Bryan W. King, Michael Reilly, Philip A. Harris, Lauren Dare, P J Gough, Viera Kasparcova, David D. Wisnoski, Barbara A. Swift
Publikováno v:
Cell Death Discovery
Necroptosis and signaling regulated by RIP1 kinase activity is emerging as a key driver of inflammation in a variety of disease settings. A significant amount has been learned about how RIP1 regulates necrotic cell death through the use of the RIP1 k
Autor:
Kirsten M. Kahler, Philip A. Harris, Paris Ward, Michael T. Ouellette, Sandra J. Hoffman, Lauren Dare, Peter J. Gough, Helen H. Sun, Carol A. Capriotti, Michelle C. Schaeffer, Christina S. Pao, Robert T. Nolte, Joshua N. Finger, Nino Campobasso, Ruth Lehr, Angela Smallwood, Deepak Bandyopadhyay, Rachel D. Totoritis, Robert W. Marquis, John D. Lich, Rakesh Nagilla, Scott B. Berger, Barbara A. Swift, John Bertin, Julie A. Cox
Publikováno v:
ACS medicinal chemistry letters. 4(12)
Potent inhibitors of RIP1 kinase from three distinct series, 1-aminoisoquinolines, pyrrolo[2,3-b]pyridines, and furo[2,3-d]pyrimidines, all of the type II class recognizing a DLG-out inactive conformation, were identified from screening of our in-hou