Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Michelle C. Gordon"'
Publikováno v:
Proceedings of the National Academy of Sciences. 94:11043-11048
The brain cholecystokinin-B/gastrin receptor (CCK-BR) is a major target for drug development because of its postulated role in modulating anxiety, memory, and the perception of pain. Drug discovery efforts have resulted in the identification of small
Publikováno v:
Molecular pharmacology. 54(5)
We have reported previously that the transmembrane domains of the cholecystokinin-B/gastrin receptor (CCK-BR) comprise a putative ligand binding pocket. In the present study, we examined whether amino acid substitutions within the CCK-BR pocket alter