Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Michelle C. Callegan"'
Autor:
Phillip S. Coburn, Frederick C. Miller, Austin L. LaGrow, Huzzatul Mursalin, Anna Gregory, Aaron Parrott, Daniel Astley, Michelle C. Callegan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
BackgroundBacillus cereus (Bc) can cause self-limiting gastrointestinal infections, but when infecting the eye, can cause rapid and irreversible blindness. This study investigated whether clinical ocular and gastrointestinal Bc isolates differed in t
Externí odkaz:
https://doaj.org/article/f8c751db63894eaba0abec0fb79ef173
Autor:
Md Huzzatul Mursalin, Roger Astley, Phillip S. Coburn, Eddy Bagaruka, Jonathan J. Hunt, Vincent A. Fischetti, Michelle C. Callegan
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Bacteriophage lytic enzymes (i.e., phage lysins) are a trending alternative for general antibiotics to combat growing antimicrobial resistance. Gram-positive Bacillus cereus causes one of the most severe forms of intraocular infection, often
Externí odkaz:
https://doaj.org/article/e812bf96d98440269b64686fa6f32da0
Autor:
Roger A. Astley, Md Huzzatul Mursalin, Phillip S. Coburn, Erin T. Livingston, James W. Nightengale, Eddy Bagaruka, Jonathan J. Hunt, Michelle C. Callegan
Publikováno v:
Microorganisms, Vol 11, Iss 7, p 1802 (2023)
Ocular infections can be medical emergencies that result in permanent visual impairment or blindness and loss of quality of life. Bacteria are a major cause of ocular infections. Effective treatment of ocular infections requires knowledge of which ba
Externí odkaz:
https://doaj.org/article/16ee1795732946c7b946c5a9c120cc50
Autor:
Ruth J. Napier, Ellen J. Lee, Michael P. Davey, Emily E. Vance, João M. Furtado, Paige E. Snow, Kimberly A. Samson, Sydney J. Lashley, Brieanna R. Brown, Reiko Horai, Mary J. Mattapallil, Biying Xu, Michelle C. Callegan, Luke S. Uebelhoer, Christina L. Lancioni, Richard K. Vehe, Bryce A. Binstadt, Justine R. Smith, Rachel R. Caspi, Holly L. Rosenzweig
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription
Externí odkaz:
https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79
Autor:
Fauziyya Muhammad, Priscilla N. Avalos, M. H. Mursalin, Jian-Xing Ma, Michelle C. Callegan, Darren J. Lee
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a
Externí odkaz:
https://doaj.org/article/5944ea9f565e489186daf391dec7940d
Autor:
Md Huzzatul Mursalin, Phillip S. Coburn, Erin Livingston, Frederick C. Miller, Roger Astley, Ana L. Flores-Mireles, Michelle C. Callegan
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Bacillus endophthalmitis is a severe intraocular infection. Hallmarks of Bacillus endophthalmitis include robust inflammation and rapid loss of vision. We reported that the absence of Bacillus surface layer protein (SLP) significantly blunted endopht
Externí odkaz:
https://doaj.org/article/784fa5b57b7b4e71b9603520dcdc2851
Autor:
Phillip S. Coburn, Frederick C. Miller, Austin L. LaGrow, Salai Madhumathi Parkunan, C. Blake Randall, Rachel L. Staats, Michelle C. Callegan
Publikováno v:
BMC Ophthalmology, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Endophthalmitis is a serious intraocular infection that frequently results in significant inflammation and vision loss. Because current therapeutics are often unsuccessful in mitigating damaging inflammation during endophthalmitis
Externí odkaz:
https://doaj.org/article/b80735c540cd4cb9bd2e27ff39233564
Autor:
Phillip S. Coburn, Frederick C. Miller, Austin L. LaGrow, Craig Land, Huzzatul Mursalin, Erin Livingston, Omar Amayem, Yijie Chen, Weiwei Gao, Liangfang Zhang, Michelle C. Callegan
Publikováno v:
mSphere, Vol 4, Iss 3 (2019)
ABSTRACT Intraocular infections are prevalent after traumatic injuries or after common ocular surgeries. Infections cause inflammation that can damage the retina and architecture of the eye, often resulting in poor visual outcomes. Severe cases may r
Externí odkaz:
https://doaj.org/article/fefdd88968b94f6a81c1c5dbdb9b386e
Autor:
Phillip S. Coburn, Frederick C. Miller, Morgan A. Enty, Craig Land, Austin L. LaGrow, Md Huzzatul Mursalin, Michelle C. Callegan
Publikováno v:
Microorganisms, Vol 8, Iss 4, p 607 (2020)
Bacillus cereus produces many factors linked to pathogenesis and is recognized for causing gastrointestinal toxemia and infections. B. cereus also causes a fulminant and often blinding intraocular infection called endophthalmitis. We reported that th
Externí odkaz:
https://doaj.org/article/2672024e3b204e52892673aa7158da66
Autor:
Austin L. LaGrow, Phillip S. Coburn, Frederick C. Miller, Craig Land, Salai Madhumathi Parkunan, Brian T. Luk, Weiwei Gao, Liangfang Zhang, Michelle C. Callegan
Publikováno v:
mSphere, Vol 2, Iss 6 (2017)
ABSTRACT Intraocular infections are a potentially blinding complication of common ocular surgeries and traumatic eye injuries. Bacterial toxins synthesized in the eye can damage intraocular tissue, often resulting in poor visual outcomes. Enteroccocu
Externí odkaz:
https://doaj.org/article/82aadfce2f2a47458f3780d1003dfb2b