Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy

Autor: Jennifer Rodriguez-Rivera, Shon A. Koren, Moriel H. Vandsburger, Tal Frolinger, Anika M.S. Hartz, Fabio Di Domenico, Emad Chishti, Chiara Lanzillotta, Ryan Cloyd, Jeffrey M. Axten, Matthew Hamm, Duc M. Duong, Alexandria Ingram, Nicholas Zulia, Nicholas J. Laping, Sarah N. Fontaine, John Koren, David K. Powell, Sara Galvis-Escobar, Nicholas T. Seyfried, Jose F. Abisambra, Michelle C. Bell

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 1186, p 1186 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 3

Tauopathies are a group of more than twenty known disorders that involve progressive neurodegeneration, cognitive decline and pathological tau accumulation. Current therapeutic strategies provide only limited, late-stage symptomatic treatment. This i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c960a4262eb4b59198d01489c573a158
https://www.mdpi.com/1422-0067/22/3/1186

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

Autor: Jennifer Rodriguez-Rivera, Jing Chen, Jose F. Abisambra, Haining Zhu, Benjamin Wolozin, Michelle C. Bell, Shelby E. Meier, Sarah N. Fontaine, Harry LeVine, Alexandria Ingram, Elizabeth Mechas, Danielle N. Lyons

Publikováno v: The Journal of Neuroscience. 36:1001-1007

One of the most common symptoms of Alzheimer's disease (AD) and related tauopathies is memory loss. The exact mechanisms leading to memory loss in tauopathies are not yet known; however, decreased translation due to ribosomal dysfunction has been imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8559529c063ff0ab05411ac09fa09e
https://doi.org/10.1523/jneurosci.3029-15.2016

Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain

Autor: Jing Chen, Peter T. Nelson, Shelby E. Meier, Jose F. Abisambra, Michelle C. Bell, John C. Gensel, Alexandria Ingram, Haining Zhu, Danielle N. Lyons

Publikováno v: Journal of Alzheimer's disease : JAD. 48(3)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is pathologically characterized by the formation of extracellular amyloid plaques and intraneuronal tau tangles. We recently identified that tau associates with proteins known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ef5cdd3dbb38afeba85cf899ecd5a3
https://pubmed.ncbi.nlm.nih.gov/26402096

P1‐163: Manganese‐enhanced magnetic resonance imaging (meMRI) measures pre‐pathological neuronal dysfunction before the appearance of tau pathology in rtg4510 mice

Autor: Moriel H. Vandsburger, Michelle C. Bell, David K. Powell, Joe F. Abisambra, Shelby E. Meier, Alexandria Ingram, Danielle N. Lyons

Publikováno v: Alzheimer's & Dementia. 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13de27be5df389ff4b5d085cd7eb7e16
https://doi.org/10.1016/j.jalz.2015.06.362

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration

Autor: Jose F. Abisambra, Michelle C. Bell, Alexandria Ingram, Shelby E. Meier

Publikováno v: Current Alzheimer research. 13(2)

The unfolded protein response (UPR) plays a vital role in maintaining cell homeostasis as a consequence of endoplasmic reticulum (ER) stress. However, prolonged UPR activity leads to cell death. This time-dependent dual functionality of the UPR repre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f742f89f7c75d8aaa05b997a96c0e0
https://pubmed.ncbi.nlm.nih.gov/26679859