Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Michelle C Y Chang"'
Autor:
David M Hershey, Xuefeng Ren, Ryan A Melnyk, Patrick J Browne, Ertan Ozyamak, Stephanie R Jones, Michelle C Y Chang, James H Hurley, Arash Komeili
Publikováno v:
PLoS Biology, Vol 14, Iss 3, p e1002402 (2016)
Many living organisms transform inorganic atoms into highly ordered crystalline materials. An elegant example of such biomineralization processes is the production of nano-scale magnetic crystals in magnetotactic bacteria. Previous studies implicated
Externí odkaz:
https://doaj.org/article/6e392fc6b51b477e83eb16389e2001e4
Autor:
Elijah N. Kissman, Monica E. Neugebauer, Kiera H. Sumida, Cameron V. Swenson, Nicholas A. Sambold, Jorge A. Marchand, Douglas C. Millar, Michelle C. Y. Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Biocatalytic C–H activation has the potential to merge enzymatic and synthetic strategies for bond formation. Fe II /αKG-dependent halogenases are particularly distinguished for their ability both to control selective C–H activation as well as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10fbe06b7e82f793f735f4393b22584a
https://doi.org/10.1073/pnas.2214512120
https://doi.org/10.1073/pnas.2214512120
Autor:
Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, Jeffrey W. Slater, Monica E. Neugebauer, Michelle C. Y. Chang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger
Publikováno v:
Biochemistry
The enzyme BesC from the β-ethynyl-L-serine biosynthetic pathway in Streptomyces cattleya fragments 4-chloro-L-lysine (produced from L-Lysine by BesD) to ammonia, formaldehyde, and 4-chloro-L-allylglycine and can analogously fragment L-Lys itself. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f6540199357ff8469be639a7484ad9
https://doi.org/10.1021/acs.biochem.1c00774
https://doi.org/10.1021/acs.biochem.1c00774
Autor:
Matthew A. Davis, Vivian Yaci Yu, Beverly Fu, Miao Wen, Edward J. Koleski, Joshua Silverman, Charles A. Berdan, Daniel K. Nomura, Michelle C. Y. Chang
Living organisms carry out a wide range of remarkable functions, including the synthesis of thousands of simple and complex chemical structures for cellular growth and maintenance. The manipulation of this reaction network has allowed for the genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2af3a115deac6a58ac575e8f0cd073a4
https://doi.org/10.1101/2023.01.09.523327
https://doi.org/10.1101/2023.01.09.523327
Autor:
Paul J. Dauenhauer, Edward J Koleski, Zhen Q. Wang, Heng Song, Michelle C. Y. Chang, Dae Sung Park, Yejin Min, Gaurav Kumar, Noritaka Hara
Publikováno v:
Nature Chemistry. 13:1178-1185
Living systems provide a promising approach to chemical synthesis, having been optimized by evolution to convert renewable carbon sources, such as glucose, into an enormous range of small molecules. However, a large number of synthetic structures can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8639ad006f30801e4ebd411605cc70e
https://doi.org/10.1038/s41557-021-00820-0
https://doi.org/10.1038/s41557-021-00820-0
Autor:
Hongjun Dong, Michelle C. Y. Chang
Publikováno v:
ACS Catalysis. 11:8948-8955
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cae788abac4d0ba50da98ca96453878
https://doi.org/10.1021/acscatal.1c01642
https://doi.org/10.1021/acscatal.1c01642
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The conversion of CO2 to value-added products allows both capture and recycling of greenhouse gas emissions. While plants and other photosynthetic organisms play a key role in closing the global carbon cycle, their dependence on light to drive carbon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834447bb3b69e0dc0bdf30e82615176c
https://doi.org/10.1073/pnas.2118638119
https://doi.org/10.1073/pnas.2118638119
Biocatalytic Asymmetric Construction of Secondary and Tertiary Fluorides from β‐Fluoro‐α‐Ketoacids**
Publikováno v:
Angewandte Chemie International Edition. 61
Fluorine is a critical element for the design of bioactive compounds, driving advances in selective and sustainable fluorination. However, stereogenic tertiary fluorides pose a synthetic challenge and are thus present in only a few approved drugs (fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b401f8782398785c95e62df1ccf8238
https://doi.org/10.1002/anie.202201602
https://doi.org/10.1002/anie.202201602
Autor:
Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, Jeffrey W. Slater, Monica Neugebauer, Michelle C. Y. Chang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger
The enzyme BesC from the β-ethynyl-L-serine biosynthetic pathway in Streptomyces cattleya fragments 4-chloro-L-lysine (produced from L-Lysine by BesD) to ammonia, formaldehyde, and 4-chloro-L-allylglycine and can analogously fragment L-Lys itself. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40260fb8d3b56448e2a91804566bd71d
https://doi.org/10.1101/2021.12.02.471016
https://doi.org/10.1101/2021.12.02.471016
Autor:
Sasilada Sirirungruang, Omer Ad, Thomas M. Privalsky, Swetha Ramesh, Joel L. Sax, Hongjun Dong, Edward E. K. Baidoo, Bashar Amer, Chaitan Khosla, Michelle C. Y. Chang
Publikováno v:
Nature chemical biology. 18(8)
Although natural products and synthetic small molecules both serve important medicinal functions, their structures and chemical properties are relatively distinct. To expand the molecular diversity available for drug discovery, one strategy is to ble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff351a1b315aecb717e43e6881ffd7e
https://pubmed.ncbi.nlm.nih.gov/35817967
https://pubmed.ncbi.nlm.nih.gov/35817967