Výsledky vyhledávání - "Michelle C, Silva"

Akademický článek

Eficácia e toxicidade da hidroxiuréia em crianças com anemia falciforme Effectiveness and toxicity of hydroxyurea in children with sickle cell anemia

Autor: Michelle C. Silva, Eliana L. T. Shimauti

Publikováno v: Revista Brasileira de Hematologia e Hemoterapia, Vol 28, Iss 2, Pp 144-148 (2006)

A anemia falciforme é uma doença genética caracterizada pelo alto índice de morbimortalidade, considerada como a mais grave entre as doenças falciformes. As opções terapêuticas mais eficazes atualmente disponíveis para tratamento desta hemog

Externí odkaz: https://doaj.org/article/4a1bfb72445543fcaa3ad250d801392d

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Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein

Autor: Michelle C. Silva, Adrian P. Wiegmans, April M. Averill, Julie A. Dragon, Scott W. Morrical, Katie E. Bryan, Milagros D. Morrical

Publikováno v: DNA repair. 60

The human RAD51 recombinase possesses DNA pairing and strand exchange activities that are essential for the error-free, homology-directed repair of DNA double-strand breaks. The recombination activities of RAD51 are activated upon its assembly into p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4ea85b0a5e0523b06732666d49cea9
https://pubmed.ncbi.nlm.nih.gov/29100040

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Polymerase manager protein UmuD directly regulates Escherichia coli DNA polymerase III binding to ssDNA

Autor: Mark C. Williams, Philip Nevin, Kathy R. Chaurasiya, Penny J. Beuning, Michelle C. Silva, Lukas Voortman, Samer Lone, Clarissa Ruslie

Publikováno v: Nucleic Acids Research

Replication by Escherichia coli DNA polymerase III is disrupted on encountering DNA damage. Consequently, specialized Y-family DNA polymerases are used to bypass DNA damage. The protein UmuD is extensively involved in modulating cellular responses to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0777c8394fdc1b6e4f42a439dbf43c14
https://doi.org/10.1093/nar/gkt648

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RAD51 Variant Proteins from Human Lung and Kidney Tumors Exhibit DNA Strand Exchange Defects

Autor: Milagros D. Morrical, Katie E. Bryan, Julie A. Dragon, Scott W. Morrical, April M. Averill, Michelle C. Silva, Jeffrey P. Bond

In human cells, error-free repair of DNA double-strand breaks requires the DNA pairing and strand exchange activities of RAD51 recombinase. Activation of RAD51 recombination activities requires the assembly of RAD51 presynaptic filaments on the singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f6d3c47caec2ef7f093e3dfeba2026
https://europepmc.org/articles/PMC4884548/

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Conformational Dynamics of the Escherichia coli DNA Polymerase Manager Proteins UmuD and UmuD′

Autor: Kasper D. Rand, Michelle C. Silva, Thomas E. Wales, Penny J. Beuning, Jing Fang, John R. Engen

Publikováno v: Journal of Molecular Biology. 398:40-53

The expression of Escherichia coli umuD gene products is upregulated as part of the SOS response to DNA damage. UmuD is initially produced as a 139-amino-acid protein, which subsequently cleaves off its N-terminal 24 amino acids in a reaction depende

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209fdf1dcca7d08208dcf9639174084d
https://doi.org/10.1016/j.jmb.2010.02.040

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