Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michelle B. Bowie"'
Autor:
Maura Gasparetto, Yun Zhao, David G. Kent, John Cheyne, Connie J. Eaves, Brad Dykstra, Michael R. Copley, Claudia Benz, Elaine Ma, Michelle B. Bowie, Allen Delaney, Yongjun Zhao, Marco A. Marra, Stefan Wöhrer, Clayton A. Smith
Publikováno v:
Blood. 113:6342-6350
Hematopoietic stem cells (HSCs) are generally defined by their dual properties of pluripotency and extensive self-renewal capacity. However, a lack of experimental clarity as to what constitutes extensive self-renewal capacity coupled with an absence
Autor:
David G. Kent, Shang-Jung Lee, Michelle B. Bowie, Lindsay McCaffrey, Ryan R. Brinkman, Brad Dykstra, Melisa J. Hamilton, Kristin Lyons, Connie J. Eaves
Publikováno v:
Cell stem cell, 1(2), 218-229. CELL PRESS
SummaryHeterogeneity in the differentiation behavior of hematopoietic stem cells is well documented but poorly understood. To investigate this question at a clonal level, we isolated a subpopulation of adult mouse bone marrow that is highly enriched
Publikováno v:
Blood. 109(11)
Fetal hematopoietic stem cells (HSCs) regenerate daughter HSCs in irradiated recipients more rapidly than do adult HSCs. However, both types of HSCs divide in vitro with the same cell-cycle transit times, suggesting different intrinsically determined
Autor:
Michelle B. Bowie, Pamela A. Hoodless, Lindsay McCaffrey, David G. Kent, Kristen D. McKnight, Connie J. Eaves
Publikováno v:
The Journal of clinical investigation. 116(10)
The regulation of HSC proliferation and engraftment of the BM is an important but poorly understood process, particularly during ontogeny. Here we show that in mice, all HSCs are cycling until 3 weeks after birth. Then, within 1 week, most became qui
Autor:
David G. Kent, Marco A. Marra, Allen Delaney, Connie J. Eaves, Yongjun Zhao, Martin Hirst, Brad Dykstra, Yun Zhao, Jay Cheyne, Michelle B. Bowie
Publikováno v:
Blood. 110:1277-1277
Recent improvements in the development of methods for isolating functionally validated populations of nearly pure (>20%) murine hematopoietic stem cells (HSCs) have made it possible to analyze the molecular basis of the properties of these cells with