Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michelle B. Crosby"'
Publikováno v:
The British Journal of Ophthalmology
Background A preliminary animal study was performed to determine if hepatic micrometastases from uveal melanoma secrete vascular endothelial growth factor (VEGF) that is measurable in serum. Methods We analysed the serum of a C57Bl/6 mouse model of u
Autor:
Michelle B. Crosby, Raya Khanin, Klaus G. Griewank, Adriana Heguy, Igor Dolgalev, Joan M. O'Brien, Catherine D. Van Raamsdonk, Michael R. Speicher, Thomas Wiesner, Ritu Roy, M. Mert Sozen, Werner Wackernagel, Swapna S. Vemula, Gail Baimukanova, Anna C. Obenauf, Klaus J. Busam, Boris C. Bastian, Gary G. R. Green, Nancy Bouvier, Maria C. Garrido
Publikováno v:
New England Journal of Medicine; Vol 363
BACKGROUND Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas. METHODS
Publikováno v:
Archives of Pathology & Laboratory Medicine. 133:1215-1218
Retinoblastoma is the most common primary intraocular tumor of childhood and may be heritable or occur sporadically. Anterior diffuse retinoblastoma is an uncommon variant that is thought to be sporadic. We describe a child with anterior diffuse reti
Autor:
Martina Sanlorenzo, Mitchell Zekhtser, Ana Latorre, Michelle B. Crosby, Gary A. Green, Igor Vujic, Jeffrey Ma, Jingly F. Weier, Anna Celli, Devron H. Char, Susana Ortiz-Urda, Denis Jusufbegovic, Christian Posch, Alfonso Latorre, Álvaro Somoza, Klemens Rappersberger, Gabriela Monico
Publikováno v:
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
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Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Early treatment may improve any chances of preventing metastatic disease, but diagnosis of small UM is challenging. Up to 95 % of all UMs carry somatic mutations in the
Autor:
Bevra H. Hahn, Gary S. Gilkeson, Chaim Putterman, Chandra Mohan, Erwin P. Bottinger, Michelle B. Crosby, Mark P. Hogarth, Jiri Zavadil, Xiaoping Qing
Publikováno v:
Arthritis & Rheumatism. 54:2198-2210
Objective Lupus-associated IgG anti–double-stranded DNA antibodies are thought to be pathogenic in the kidney due to cross-reaction with glomerular antigens, leading subsequently to immune complex formation in situ and complement activation. We und
Autor:
Tamara M. Nowling, Michelle B. Crosby, Christopher J. Nicol, Gary S. Gilkeson, John Zhang, Frank J. Gonzalez, John L. Svenson
Publikováno v:
Clinical Immunology. 118:276-283
Nitric oxide (NO) production increases with age in the lupus-prone MRL/lpr mouse, paralleling disease activity. One mechanism for excess NO production in MRL/lpr mice may be a defect in down-regulatory mechanisms of the iNOS pathway. A potential modu
Autor:
Michelle B. Crosby, Gary S. Gilkeson, Frank J. Gonzalez, John L. Svenson, Christopher J. Nicol, John Zhang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:69-76
Peroxisome proliferation-activated receptor (PPAR)gamma agonists inhibit inducible nitric-oxide synthase (iNOS), tumor necrosis factor-alpha, and interleukin-6. Because of these effects, synthetic PPARgamma agonists, including thiazolidinediones, are
Autor:
Johnny Sudian, Michelle B. Crosby, Jim C. Oates, Christopher M. Reilly, Perry V. Halushka, Gary S. Gilkeson
Publikováno v:
Clinical Immunology. 98:337-345
Mesangial cells from MRL/lpr mice, a model of lupus, overproduce nitric oxide (NO) compared to controls. J series prostaglandins (PG) and thiazolidinediones block LPS stimulation of NO production via the activation of peroxisome proliferator-activato
Autor:
Michelle B. Crosby, Xiaoping Qing, Gary S. Gilkeson, Jiri Zavadil, Chaim Putterman, Erwin P. Bottinger
Publikováno v:
Autoimmunity Reviews. 3:607-609
Publikováno v:
Cornea. 28(8)
Lichen planus is a chronic inflammatory disease that can affect both the skin and mucosa. Although more commonly affecting the oral and genital mucosa, it can also affect the conjunctiva, causing cicatrization in rare cases. It has been reported prev