Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

Autor: Bowen Zhang, Zhenhua Zhang, Valerie A.C.M. Koeken, Saumya Kumar, Michelle Aillaud, Hsin-Chieh Tsay, Zhaoli Liu, Anke R.M. Kraft, Chai Fen Soon, Ivan Odak, Berislav Bošnjak, Anna Vlot, Morris A. Swertz, Uwe Ohler, Robert Geffers, Thomas Illig, Jochen Huehn, Antoine-Emmanuel Saliba, Leif Erik Sander, Reinhold Förster, Cheng-Jian Xu, Markus Cornberg, Leon N. Schulte, Yang Li

Publikováno v: Cell Genomics, Vol 3, Iss 2, Pp 100232- (2023)

Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe COVID-19 in some patients and mild COVID-19 in others. Dysfunctional innate immune responses have been identified to contribute to COVID-19 severity, but th

Externí odkaz: https://doaj.org/article/1d8a821dff98448fb35c91743f5b812b

Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

Autor: Marina Aznaourova, Nils Schmerer, Harshavardhan Janga, Zhenhua Zhang, Kim Pauck, Judith Bushe, Sarah M. Volkers, Daniel Wendisch, Philipp Georg, Evgenia Ntini, Michelle Aillaud, Margrit Gündisch, Elisabeth Mack, Chrysanthi Skevaki, Christian Keller, Christian Bauer, Wilhelm Bertrams, Annalisa Marsico, Andrea Nist, Thorsten Stiewe, Achim D. Gruber, Clemens Ruppert, Yang Li, Holger Garn, Leif E. Sander, Bernd Schmeck, Leon N. Schulte

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 119(36):e2120680119. NATL ACAD SCIENCES
Proc. Natl. Acad. Sci. U.S.A. 119:e2120680119 (2022)

The systemic immune response to viral infection is shaped by master transcription factors, such as NF-κB, STAT1, or PU.1. Although long noncoding RNAs (lncRNAs) have been suggested as important regulators of transcription factor activity, their cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6e9b9cc495c2b5ca7715dc298620bf
https://pubmed.ncbi.nlm.nih.gov/35998224