Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michelle A. Utton"'
Autor:
Andrew D. Hope, Rina Bandopadhyay, Andrew J. Lees, R de Silva, G M Gibb, Brian H. Anderton, C Strand, T Jowett, T Revesz, Nicola Wood, Nadeem A. Khan, Tammaryn Lashley, Diane P. Hanger, JL Holton, Andrew R. Reid, Michelle A. Utton
Publikováno v:
Neuropathology and Applied Neurobiology. 29:288-302
Pathological inclusions containing fibrillar aggregates of hyperphosphorylated tau protein are a characteristic feature in the tauopathies, which include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f62d05efaf43503167fdaca47afe415
https://doi.org/10.1046/j.1365-2990.2003.00463.x
https://doi.org/10.1046/j.1365-2990.2003.00463.x
Publikováno v:
Journal of Neurochemistry. 76:1421-1430
A chimeric molecule consisting of the extracellular domain of the adhesion molecule, N-cadherin, fused to the Fc region of human IgG (NCAD-Fc) supports calcium-dependent cell adhesion and promotes neurite outgrowth following affinity-capture to a tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79c12b32749d8a5d26d08a030c697924
https://doi.org/10.1046/j.1471-4159.2001.00140.x
https://doi.org/10.1046/j.1471-4159.2001.00140.x
Publikováno v:
Europe PubMed Central
Tau is a neuronal microtubule-associated protein that appears to function in the formation and maintenance of axons by influencing microtubule organisation. Tau is a phosphoprotein and is more heavily phosphorylated in fetal than in adult brain, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61359e5b964ed1881374ccf9bf74ab2
https://doi.org/10.1242/jcs.109.6.1537
https://doi.org/10.1242/jcs.109.6.1537
Publikováno v:
Cell Motility and the Cytoskeleton. 35:134-146
The regulation of microtubule dynamics in vitro by microtubule-associated proteins (MAPs) was examined, using purified porcine MAP1B and MAP2. MAP1B has a significantly smaller effect on the observed critical concentration for microtubule assembly th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52a4832b1fb6c223424d3c3742079253
https://doi.org/10.1002/(sici)1097-0169(1996)35:2<134::aid-cm6>3.0.co
https://doi.org/10.1002/(sici)1097-0169(1996)35:2<134::aid-cm6>3.0.co
Publikováno v:
Journal of cell science. 118(Pt 20)
Tau and alpha-synuclein are both proteins implicated in the pathology of neurodegenerative disease. Here we have investigated the mechanisms of axonal transport of tau and alpha-synuclein, because failure of axonal transport has been implicated in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee9587b11c9c4d835f8447fefa201d0
https://pubmed.ncbi.nlm.nih.gov/16176937
https://pubmed.ncbi.nlm.nih.gov/16176937
Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons
Autor:
Christopher C.J. Miller, Ayodeji A. Asuni, Andrew J. Grierson, Diane P. Hanger, Michelle A. Utton, Alun M. Davies, Steven Ackerley, Brian H. Anderton, Vladimir L. Buchman, Josephine E. Hill, Anirban R. Saha
Publikováno v:
Journal of cell science. 117(Pt 7)
Alpha-synuclein is a major protein constituent of Lewy bodies and mutations in alpha-synuclein cause familial autosomal dominant Parkinson's disease. One explanation for the formation of perikaryal and neuritic aggregates of alpha-synuclein, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbf9184699374a762bbeb5906057c8e
https://pubmed.ncbi.nlm.nih.gov/14996933
https://pubmed.ncbi.nlm.nih.gov/14996933
Autor:
Marjon Van Slegtenhorst, Andrew J. Lees, James Connell, Mike Hutton, Michelle A. Utton, Rohan de Silva, Christopher C.J. Miller, Ayodeji A. Asuni, Brian H. Anderton
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(15)
We demonstrate that the microtubule-associated protein tau, in the form of enhanced green fluorescent protein (EGFP) tau, is transported along axons of neurons in culture in the slow component of axonal transport with a speed comparable with that pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a135ea1c49b3cdf581a81ddc008c5e3
https://pubmed.ncbi.nlm.nih.gov/12151518
https://pubmed.ncbi.nlm.nih.gov/12151518
Publikováno v:
The Journal of biological chemistry. 276(36)
We report functional differences between tau isoforms with 3 or 4 C-terminal repeats and a difference in susceptibility to oxidative conditions, with respect to the regulation of microtubule dynamics in vitro and tau-microtubule binding in cultured c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63507f7438d7728eaaccc7567107717
https://pubmed.ncbi.nlm.nih.gov/11438517
https://pubmed.ncbi.nlm.nih.gov/11438517
Publikováno v:
Neurobiology of Aging. 25:S428
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c01a39a426aba9692c119124256d0a1
https://doi.org/10.1016/s0197-4580(04)81408-8
https://doi.org/10.1016/s0197-4580(04)81408-8
Autor:
Richard Killick, Andrew J. Grierson, Simon Lovestone, Michelle A. Utton, Steve Ackerly, Christopher C.J. Miller
Publikováno v:
Neurobiology of Aging. 21:113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d74ba5e132b02cd8c05f915bd65f5207
https://doi.org/10.1016/s0197-4580(00)82308-8
https://doi.org/10.1016/s0197-4580(00)82308-8