Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Michelle A. Sugimoto"'
Autor:
Karen T. Feehan, Hannah E. Bridgewater, Jan Stenkiewicz-Witeska, Roel P. H. De Maeyer, John Ferguson, Matthias Mack, Jeremy Brown, Giuseppe Ercoli, Connar M. Mawer, Arne N. Akbar, James R. W. Glanville, Parinaaz Jalali, Olivia V. Bracken, Anna Nicolaou, Alexandra C. Kendall, Michelle A. Sugimoto, Derek W. Gilroy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Resolving inflammation is thought to return the affected tissue back to homoeostasis but recent evidence supports a non-linear model of resolution involving a phase of prolonged immune activity. Here we show that within days following resolu
Externí odkaz:
https://doaj.org/article/2c3602528dd144b09810421a90f86c86
Autor:
Juliana P. Vago, Isabella Zaidan, Luiza O. Perucci, Larissa Froede Brito, Lívia C.R. Teixeira, Camila Meirelles Souza Silva, Thaís C. Miranda, Eliza M. Melo, Alexandre S. Bruno, Celso Martins Queiroz-Junior, Michelle A. Sugimoto, Luciana P. Tavares, Laís C. Grossi, Isabela N. Borges, Ayda Henriques Schneider, Nagyung Baik, Ayda H. Schneider, André Talvani, Raphael G. Ferreira, José C. Alves-Filho, Vandack Nobre, Mauro M. Teixeira, Robert J. Parmer, Lindsey A. Miles, Lirlândia P. Sousa
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Sepsis is a lethal syndrome characterized by systemic inflammation and abnormal coagulation. Despite therapeutic advances, sepsis mortality remains substantially high. Herein, we investigated the role of the plasminogen/plasmin (Plg/Pla) system durin
Externí odkaz:
https://doaj.org/article/a65d5415319d433fa20d04546ae5d303
Autor:
Natalya Khodeneva, Michelle A. Sugimoto, Camilla S. A. Davan-Wetton, Trinidad Montero-Melendez
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Stromal cells have emerged as central drivers in multiple and diverse diseases, and consequently, as potential new cellular targets for the development of novel therapeutic strategies. In this review we revise the main roles of fibroblasts, not only
Externí odkaz:
https://doaj.org/article/31033dae72d842c491c9da0faaec4aa0
Autor:
Isabella Zaidan, Luciana P. Tavares, Michelle A. Sugimoto, Kátia M. Lima, Graziele L. Negreiros-Lima, Lívia C.R. Teixeira, Thais C. Miranda, Bruno V.S. Valiate, Allysson Cramer, Juliana Priscila Vago, Gabriel H. Campolina-Silva, Jéssica A.M. Souza, Laís C. Grossi, Vanessa Pinho, Maria Jose Campagnole-Santos, Robson A.S. Santos, Mauro M. Teixeira, Izabela Galvão, Lirlândia P. Sousa
Publikováno v:
JCI Insight, Vol 7, Iss 1 (2022)
Nonphlogistic migration of macrophages contributes to the clearance of pathogens and apoptotic cells, a critical step for the resolution of inflammation and return to homeostasis. Angiotensin-(1-7) [Ang-(1-7)] is a heptapeptide of the renin-angiotens
Externí odkaz:
https://doaj.org/article/d35298a52e524d41a0083e081a6b11a4
Autor:
Simone de Araújo, Victor R. de Melo Costa, Franciele M. Santos, Carla D. Ferreira de Sousa, Thaiane P. Moreira, Matheus R. Gonçalves, Franciel B. Félix, Celso M. Queiroz-Junior, Gabriel H. Campolina-Silva, Maurício Lacerda Nogueira, Michelle A. Sugimoto, Caio S. Bonilha, Mauro Perretti, Danielle G. Souza, Vivian V. Costa, Mauro M. Teixeira
Publikováno v:
Cells, Vol 11, Iss 17, p 2717 (2022)
Chikungunya (CHIKV) is an arthritogenic alphavirus that causes a self-limiting disease usually accompanied by joint pain and/or polyarthralgia with disabling characteristics. Immune responses developed during the acute phase of CHIKV infection determ
Externí odkaz:
https://doaj.org/article/d66224f1d2c944f59ee75dc39283206a
Autor:
Jianmin Chen, Gareth S. D. Purvis, Debora Collotta, Sura Al Zoubi, Michelle A. Sugimoto, Antonino Cacace, Lukas Martin, Roman A. Colas, Massimo Collino, Jesmond Dalli, Christoph Thiemermann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The development of cardiac dysfunction caused by microbial infection predicts high mortality in sepsis patients. Specialized pro-resolving mediators (SPMs) mediate resolution of inflammation in many inflammatory diseases, and are differentially expre
Externí odkaz:
https://doaj.org/article/c7482dcbf24248e5a3d10685dc45970b
Autor:
Juliana P. Vago, Michelle A. Sugimoto, Kátia M. Lima, Graziele L. Negreiros-Lima, Nagyung Baik, Mauro M. Teixeira, Mauro Perretti, Robert J. Parmer, Lindsey A. Miles, Lirlândia P. Sousa
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Inflammation resolution is an active process that functions to restore tissue homeostasis. Clearance of apoptotic leukocytes by efferocytosis at inflammatory sites plays an important role in inflammation resolution and induces remarkable macrophage p
Externí odkaz:
https://doaj.org/article/467e28c9c5f74cbab313a6308e481f5c
Autor:
Graziele L. Negreiros-Lima, Kátia M. Lima, Isabella Z. Moreira, Bruna Lorrayne O. Jardim, Juliana P. Vago, Izabela Galvão, Lívia Cristina R. Teixeira, Vanessa Pinho, Mauro M. Teixeira, Michelle A. Sugimoto, Lirlândia P. Sousa
Publikováno v:
Cells, Vol 9, Iss 1, p 128 (2020)
Macrophages are central to inflammation resolution, an active process aimed at restoring tissue homeostasis following an inflammatory response. Here, the effects of db-cAMP on macrophage phenotype and function were investigated. Injection of db-cAMP
Externí odkaz:
https://doaj.org/article/1ca1ec4e8029485f826be2b447e24389
Autor:
Michelle A. Sugimoto, Márcia de Jesus Amazonas da Silva, Larissa Froede Brito, Rosivaldo dos Santos Borges, Flávio Almeida Amaral, Ana Paula de Araujo Boleti, Maritza Echevarria Ordoñez, Jose Carlos Tavares, Lirlandia Pires Sousa, Emerson Silva Lima
Publikováno v:
Molecules, Vol 22, Iss 11, p 1977 (2017)
Inflammation is a reaction of the host to infectious or sterile stimuli and has the physiological purpose of restoring tissue homeostasis. However, uncontrolled or unresolved inflammation can lead to tissue damage, giving rise to a plethora of chroni
Externí odkaz:
https://doaj.org/article/9799806008f5484eac39ff587fcfa165
Autor:
Lirlândia P. Sousa, Michelle A. Sugimoto, Luiza O. Perucci, Luciana P. Tavares, Mauro M. Teixeira
Publikováno v:
Current Drug Targets. 23:1578-1592
Abstract: COVID-19 is a multisystem disease caused by SARS-CoV-2 and is associated with an imbalance between the coagulation and fibrinolytic systems. Overall, hypercoagulation, hypofibri-nolysis and fibrin-clot resistance to fibrinolysis predispose