Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michelle A. Booden"'
Autor:
Michelle A. Booden
Ha-Ras undergoes post-translational modifications (including attachment of famesyl and palmitate) that culminate in localization of the protein to the plasma membrane. Because palmitate is not attached without prior farnesyl addition, the distinct co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f0478a44fc9422bbbedb62765d9c2f
https://doi.org/10.31274/rtd-180813-13776
https://doi.org/10.31274/rtd-180813-13776
Autor:
Timothy A. Fields, Michelle A. Booden, Patrick J. Kelly, Channing J. Der, Benjamin J. Moeller, Mark W. Dewhirst, Patrick J. Casey, Yehia Daaka, Juhi Juneja
Publikováno v:
Proceedings of the National Academy of Sciences. 103:8173-8178
Although the prognosis for patients with early-stage breast cancer has improved, the therapeutic options for patients with locally advanced and metastatic disease are limited. To improve the treatment of these patients, the molecular mechanisms under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac74f48a447f261b02e951b9a596f68a
https://doi.org/10.1073/pnas.0510254103
https://doi.org/10.1073/pnas.0510254103
Publikováno v:
Molecular and Cellular Biology. 24:1990-1999
Increased expression of protease-activated receptor 1 (PAR1), a G protein-coupled receptor for thrombin, has previously been correlated with breast carcinoma cell invasion. PAR1 is irreversibly proteolytically activated, internalized, and sorted dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f47daf5f89294a7618ad6a42dcc0233
https://doi.org/10.1128/mcb.24.5.1990-1999.2004
https://doi.org/10.1128/mcb.24.5.1990-1999.2004
Publikováno v:
Molecular and Cellular Biology. 22:4053-4061
Leukemia-associated Rho guanine-nucleotide exchange factor (LARG) belongs to the subfamily of Dbl homology RhoGEF proteins (including p115 RhoGEF and PDZ-RhoGEF) that possess amino-terminal regulator of G protein signaling (RGS) boxes also found with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9afcb23c7a36bc5d659655f0afa59a
https://doi.org/10.1128/mcb.22.12.4053-4061.2002
https://doi.org/10.1128/mcb.22.12.4053-4061.2002
Publikováno v:
Molecular and Cellular Biology. 22:2487-2497
Vav2, like all Dbl family proteins, possesses tandem Dbl homology (DH) and pleckstrin homology (PH) domains and functions as a guanine nucleotide exchange factor for Rho family GTPases. Whereas the PH domain is a critical positive regulator of DH dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5836ddc078f34d76458a81a8ca7a39e
https://doi.org/10.1128/mcb.22.8.2487-2497.2002
https://doi.org/10.1128/mcb.22.8.2487-2497.2002
Autor:
Michelle A. Booden, Brian Becknell, Gary W. Reuther, John Sondek, Guido Marcucci, Michael A. Caligiuri, Channing J. Der, Que T. Lambert, Krister Wennerberg
Publikováno v:
Journal of Biological Chemistry. 276:27145-27151
Leukemia-associated Rho guanine nucleotide exchange factor (LARG) was originally identified as a fusion partner with mixed-lineage leukemia in a patient with acute myeloid leukemia. LARG possesses a tandem Dbl homology and pleckstrin homology domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526fea723ca953da191176272ed77012
https://doi.org/10.1074/jbc.m103565200
https://doi.org/10.1074/jbc.m103565200
Publikováno v:
Journal of Biological Chemistry. 275:22037-22047
Ha-Ras is modified by isoprenoid on Cys(186) and by reversibly attached palmitates at Cys(181) and Cys(184). Ha-Ras loses 90% of its transforming activity if Cys(181) and Cys(184) are changed to serines, implying that palmitates make important contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dfffdc3ca5b914f9f99003a7b7b71b
https://doi.org/10.1074/jbc.m001813200
https://doi.org/10.1074/jbc.m001813200
Publikováno v:
Biochemistry. 38:12926-12934
H-Ras is95% membrane-bound when modified by farnesyl and palmitate, but10% membrane-bound if only farnesyl is present, implying that palmitate provides major support for membrane interaction. However the direct contribution of palmitate to H-Ras memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a3ca5315b3ca1976de19a0e2dc26a4
https://doi.org/10.1021/bi9909290
https://doi.org/10.1021/bi9909290
Publisher Summary This chapter describes the application of various cellular assays for examining the growth transformation caused by GPCR oncogenes that promote the aberrant activation of Rho family small GTPases. A critical step in the validation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::871b32345ac4cefedca837ba2465f7c3
https://doi.org/10.1016/b978-012164730-8/50042-3
https://doi.org/10.1016/b978-012164730-8/50042-3
Autor:
Ernesto J. Fuentes, Channing J. Der, Antoine E. Karnoub, Sharon L. Campbell, Michelle A. Booden
Publikováno v:
The Journal of biological chemistry. 278(23)
Dbl family proteins act as guanine nucleotide exchange factors and positive regulators of Rho GTPase function by stimulating formation of the active, GTP-bound state. All Dbl family Rho guanine nucleotide exchange factors possess an invariant tandem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6013bd49a8d00a8d4efcbb016af8c31c
https://pubmed.ncbi.nlm.nih.gov/12637530
https://pubmed.ncbi.nlm.nih.gov/12637530