Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Michelle A. Scott"'
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-11 (2024)
ABSTRACTSmall nucleolar RNAs (snoRNAs) are a class of conserved noncoding RNAs forming complexes with proteins to catalyse site-specific modifications on ribosomal RNA. Besides this canonical role, several snoRNAs are now known to regulate diverse le
Externí odkaz:
https://doaj.org/article/8a82dda95a2847538b50912c150cf24e
Autor:
Cécilia Légaré, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Andrée-Anne Clément, Cédrik Poirier, Zhong-Cheng Luo, Michelle S. Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert, Luigi Bouchard
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1285 (2024)
Maternal blood glucose regulation adaptation to pregnancy aims to support fetal growth but may also lead to the development of gestational diabetes mellitus, the most common pregnancy complication. MiRNAs are small RNA molecules secreted and stable i
Externí odkaz:
https://doaj.org/article/bae7fa08ebb749ce8117b867cffec14a
Autor:
Danny Bergeron, Laurence Faucher-Giguère, Ann-Kathrin Emmerichs, Karine Choquet, Kristina Sungeun Song, Gabrielle Deschamps-Francoeur, Étienne Fafard-Couture, Andrea Rivera, Sonia Couture, L. Stirling Churchman, Florian Heyd, Sherif Abou Elela, Michelle S. Scott
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Background Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best known for their involvement in ribosomal RNA maturation. In mammals, most expressed snoRNAs are embedded in introns of longer genes and produced through transcription
Externí odkaz:
https://doaj.org/article/9cacce3aeec94e56b9bf6649e0fa23d4
Autor:
Sébastien Leblanc, Marie A. Brunet, Jean-François Jacques, Amina M. Lekehal, Andréa Duclos, Alexia Tremblay, Alexis Bruggeman-Gascon, Sondos Samandi, Mylène Brunelle, Alan A. Cohen, Michelle S. Scott, Xavier Roucou
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 3, Pp 515-534 (2023)
Recent proteogenomic approaches have led to the discovery that regions of the transcriptome previously annotated as non-coding regions [i.e., untranslated regions (UTRs), open reading frames overlapping annotated coding sequences in a different readi
Externí odkaz:
https://doaj.org/article/7063003343fe4f088a982f401b17848e
Autor:
Nguyen Hoang Dong, Lortie Audrey, Mbous Nguimbus Leopold, Marrugo Javier, Allard‐Chamard Hugues, Bouchard Luigi, Boire Gilles, Michelle S Scott, Roux Sophie
Publikováno v:
JBMR Plus, Vol 7, Iss 8, Pp n/a-n/a (2023)
In rheumatoid arthritis (RA), only a subset of patients develop irreversible bone destruction. Our aim was to identify a microRNA (miR)‐based osteoclast‐related signature predictive of erosiveness in RA. Seventy‐six adults with erosive (E) or n
Externí odkaz:
https://doaj.org/article/96fe34f780f742cca90f8dd0ca620288
Autor:
Kyra Kerkhofs, Jyoti Garg, Étienne Fafard-Couture, Sherif Abou Elela, Michelle S. Scott, Ronald E. Pearlman, Mark A. Bayfield
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
La proteins are conserved factors critical for the maturation of RNA polymerase III transcripts. In the ciliate T. thermophila and related alveolates, La proteins have a novel domain arrangement and are linked to a distinct pre-tRNA processing pathwa
Externí odkaz:
https://doaj.org/article/ff657c925cdb4b6d9d25c4e5168dea34
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Most yeast ribosomal protein genes are duplicated but the functional significance of this duplication remains unclear. This study identifies a natural program where changing the ratio of proteins produced from duplicated genes modifies translation in
Externí odkaz:
https://doaj.org/article/59e718ee8de54ccd8e88cb61887fbee7
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Alternative splicing can increase the diversity of gene functions by generating multiple isoforms with different sequences and functions. However, the extent to which splicing events have functional consequences remains unclear an
Externí odkaz:
https://doaj.org/article/8143bdd440454c0987c3385c5acd3aae
Autor:
Anaïs Chauvin, Danny Bergeron, Jean Vencic, Dominique Lévesque, Benoit Paquette, Michelle S. Scott, François-Michel Boisvert
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-19 (2022)
Abstract Radio-chemotherapy with 5-flu orouracil (5-FU) is the standard of care treatment for patients with colorectal cancer, but it is only effective for a third of them. Despite our understanding of the mechanism of action of 5-FU, drug resistance
Externí odkaz:
https://doaj.org/article/6f5d63c87f5e49a7aec13b88f9c87ebc
Autor:
Cécilia Légaré, Andrée-Anne Clément, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Simon-Pierre Guay, Benoit J. Arsenault, Michelle S. Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert, Luigi Bouchard
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background During pregnancy, maternal metabolism undergoes substantial changes to support the developing fetus. Such changes are finely regulated by different mechanisms carried out by effectors such as microRNAs (miRNAs). These small non-co
Externí odkaz:
https://doaj.org/article/fcbd58a1d66b40708e2736977b1c3050