Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years

Autor: Michelle A. Neller, George R. Ambalathingal, Nada Hamad, Joe Sasadeusz, Rebecca Pearson, Chien-Li Holmes-Liew, Deepak Singhal, Matthew Tunbridge, Wei Yang Ng, Kirsty Sharplin, Andrew Moore, David Deambrosis, Trisha Soosay-Raj, Peter McNaughton, Morag Whyte, Chris Fraser, Andrew Grigg, David Kliman, Ashish Bajel, Katherine Cummins, Mark Dowling, Zhi Han Yeoh, Simon J. Harrison, Amit Khot, Sarah Tan, Izanne Roos, Ray Mun Koo, Sara Dohrmann, David Ritchie, Brynn Wainstein, Karen McCleary, Adam Nelson, Bradley Gardiner, Shafqat Inam, Xavier Badoux, Kris Ma, Claudia Toro, Diane Hanna, David Hughes, Rachel Conyers, Theresa Cole, Shiqi Stacie Wang, Lynette Chee, Jacqueline Fleming, Ashley Irish, Duncan Purtill, Julian Cooney, Peter Shaw, Siok-Keen Tey, Stewart Hunt, Elango Subramonia Pillai, George John, Michelle Ng, Shanti Ramachandran, Peter Hopkins, Daniel Chambers, Scott Campbell, Ross Francis, Nicole Isbel, Paula Marlton, Hilary Reddiex, Katherine K. Matthews, Meggie Voogt, Archana Panikkar, Leone Beagley, Sweera Rehan, Shannon Best, Jyothy Raju, Laetitia Le Texier, Pauline Crooks, Matthew Solomon, Lea Lekieffre, Sriganesh Srihari, Corey Smith, Rajiv Khanna

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across

Externí odkaz: https://doaj.org/article/8c099c749c664bdd91639b09344ded19

Breakthrough SARS-COV-2 infection induces broad anti-viral T cell immunity

Autor: Katie Eireann Lineburg, Pauline Crooks, Jyothy Raju, Laetitia Le Texier, Panteha Khaledi, Kiana Berry, Srividhya Swaminathan, Archana Panikkar, Sweera Rehan, Kristyan Guppy-Coles, Michelle Anne Neller, Rajiv Khanna, Corey Smith

Publikováno v: iScience, Vol 26, Iss 12, Pp 108474- (2023)

Summary: Vaccines have curtailed the devastation wrought by COVID-19. Nevertheless, emerging variants result in a high incidence of breakthrough infections. Here we assess the impact of vaccination and breakthrough infection on severe acute respirato

Externí odkaz: https://doaj.org/article/ba39effdad3542afbe212dca5dfdc0a7

Complete response to PD-1 blockade following EBV-specific T-cell therapy in metastatic nasopharyngeal carcinoma

Autor: Corey Smith, Margaret McGrath, Michelle A. Neller, Katherine K. Matthews, Pauline Crooks, Laetitia Le Texier, Benedict Panizza, Sandro Porceddu, Rajiv Khanna

Publikováno v: npj Precision Oncology, Vol 5, Iss 1, Pp 1-5 (2021)

Abstract Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated heterogeneous disease and is characterized by peritumoral immune infiltrate. Adoptive T-cell therapy (ACT) has emerged as a potential therapeutic strategy for NPC. Ho

Externí odkaz: https://doaj.org/article/2ff4c31e55df41fc9e1e70e5cbd4cff1

SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants.

Autor: Archana Panikkar, Katie E Lineburg, Jyothy Raju, Keng Yih Chew, George R Ambalathingal, Sweera Rehan, Srividhya Swaminathan, Pauline Crooks, Laetitia Le Texier, Leone Beagley, Shannon Best, Matthew Solomon, Katherine K Matthews, Sriganesh Srihari, Michelle A Neller, Kirsty R Short, Rajiv Khanna, Corey Smith

Publikováno v: PLoS Pathogens, Vol 18, Iss 2, p e1010339 (2022)

Adoptive T-cell immunotherapy has provided promising results in the treatment of viral complications in humans, particularly in the context of immunocompromised patients who have exhausted all other clinical options. The capacity to expand T cells fr

Externí odkaz: https://doaj.org/article/c3b87232ebed482692dd6783b41f36ec

'Off-the-shelf’ allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies

Autor: Debottam Sinha, Sriganesh Srihari, Kirrliee Beckett, Laetitia Le Texier, Matthew Solomon, Archana Panikkar, George R Ambalathingal, Lea Lekieffre, Pauline Crooks, Sweera Rehan, Michelle A. Neller, Corey Smith, Rajiv Khanna

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)

Background Epstein-Barr virus (EBV), an oncogenic human gammaherpesvirus, is associated with a wide range of human malignancies of epithelial and B-cell origin. Recent studies have demonstrated promising safety and clinical efficacy of allogeneic ‘

Externí odkaz: https://doaj.org/article/7329e6da10914da88a5c8a14d23ece3f