Výsledky vyhledávání - "Michellamine B"

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Repurposing Multi-Targeting Plant Natural Product Scaffolds In Silico Against SARS-CoV-2 Non-Structural Proteins Implicated in Viral Pathogenesis

Autor: Allan Patrick Macabeo, Kin Israel Notarte, Mark Tristan J. Quimque, James Kyle Ching, Rey Arturo T. Fernandez, Delfin Yñigo H. Pilapil, Joe Anthony Manzano, Von Novi de Leon

Background: Accessing COVID-19 vaccines is a challenge despite successful clinical trials. This burdens the COVID-19 treatment gap, thereby requiring accelerated discovery of anti-SARS-CoV-2 agents. Thus, this study explored the potential of anti-HIV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e537236de04a039051b3300e040dc6
https://doi.org/10.26434/chemrxiv.14125433

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Small Molecule Condensin Inhibitors

Autor: Hang Zhao, John K. Walker, Valentin V. Rybenkov, Jerome Baudry, Helen I. Zgurskaya, Zoya M. Petrushenko

Publikováno v: ACS Infectious Diseases. 4:1737-1745

Condensins play a unique role in orchestrating the global folding of the chromosome, an essential cellular process, and contribute to human disease and bacterial pathogenicity. As such, they represent an attractive and as yet untapped target for dive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2165f354f974941d071519a88291334
https://doi.org/10.1021/acsinfecdis.8b00222

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Computational Study of Michellamines: Naphthylisoquinoline Alkaloids with Anti-HIV Activity

Autor: Liliana Mammino, Mireille K. Bilonda

Publikováno v: Quantum Systems in Physics, Chemistry, and Biology ISBN: 9783319502540

Michellamine A, michellamine B and michellamine C are naphthylisoquinoline alkaloids with anti-HIV activity isolated from the leaves of Ancistrocladus korupensis, a plant indigenous in Cameroun. Michellamine B and michellamine C are atropisomeric of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64c2e70463c4767d2577c85bd0f432e4
https://doi.org/10.1007/978-3-319-50255-7_18

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Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B

Autor: Justinas Slikas, Agnes Mihalyi, Timothy D. H. Bugg, Shirin Jamshidi

Publikováno v: Bioorganic & Medicinal Chemistry. 22:4566-4571

The National Cancer Institute (NCI) Diversity Set was screened for potential inhibitors of phospho-MurNAc-pentapeptide translocase MraY from Escherichia coli using a primary fluorescence enhancement assay, followed by a secondary radiochemical assay.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0037cd49b44414c87f73bc31258c7607
https://doi.org/10.1016/j.bmc.2014.07.035

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Akademický článek

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Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions

Autor: Chris H. Senanayake, Wenzhen Fu, Guangqing Xu, Guodu Liu, Wenjun Tang

Publikováno v: Journal of the American Chemical Society. 136:570-573

Efficient asymmetric Suzuki-Miyaura coupling reactions are employed for the first time in total syntheses of chiral biaryl natural products korupensamine A and B in combination with an effective diastereoselective hydrogenation, allowing ultimately a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0bfc11b6637088f2c835612426e3d1
https://doi.org/10.1021/ja409669r

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ChemInform Abstract: Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions

Autor: Wenzhen Fu, Guangqing Xu, Wenjun Tang, Chris H. Senanayake, Guodu Liu

Publikováno v: ChemInform. 45

Application of this method is demonstrated by the total synthesis of both isomers of Korupensamine (XIII) with inverse axial chirality and the heterodimerization product Michellamine (XIV).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c764b66c1c63642aa16dde97ac3342b
https://doi.org/10.1002/chin.201430029

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Michellamines D−F, New HIV-Inhibitory Dimeric Naphthylisoquinoline Alkaloids, and Korupensamine E, a New Antimalarial Monomer, from Ancistrocladus korupensis

Autor: G. Bringmann, Robert J. Gulakowski, Kirk P. Manfredi, James B. McMahon, Yali F. Hallock, Klaus-Peter Gulden, Jin-Rui Dai, Michael R. Boyd, John H. Cardellina, Manuela Schäffer, Guido François, Martin Stahl

Publikováno v: Journal of Natural Products. 60:677-683

New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from extracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and ster

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74acca1226c8bfeb2fe89bfb4480f6d
https://doi.org/10.1021/np9700679

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