Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Michelino Puopolo"'
Autor:
Diane M. Bogdan, Keith Studholme, Adriana DiBua, Chris Gordon, Martha P. Kanjiya, Mei Yu, Michelino Puopolo, Martin Kaczocha
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The endocannabinoid anandamide (AEA) produces antinociceptive effects by activating cannabinoid receptor 1 (CB1). However, AEA also serves as an agonist at transient receptor potential vanilloid receptor 1 (TRPV1) in nociceptive sensory neur
Externí odkaz:
https://doaj.org/article/c1cb01ae7c1e46c1ab55a8d0f95094d3
Autor:
Michelino Puopolo
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 6, Pp 925-930 (2019)
Nociceptive signals conveyed to the dorsal horn of the spinal cord by primary nociceptors are subject to extensive modulation by local neurons and by supraspinal descending pathways to the spinal cord before being relayed to higher brain centers. Des
Externí odkaz:
https://doaj.org/article/60b3cfcd22024cd4ae1a63bdc2e76874
Autor:
Seungkyu Lee, Sooyeon Jo, Sébastien Talbot, Han-Xiong Bear Zhang, Masakazu Kotoda, Nick A Andrews, Michelino Puopolo, Pin W Liu, Thomas Jacquemont, Maud Pascal, Laurel M Heckman, Aakanksha Jain, Jinbo Lee, Clifford J Woolf, Bruce P Bean
Publikováno v:
eLife, Vol 8 (2019)
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of lo
Externí odkaz:
https://doaj.org/article/de64bb25275445b0a3e4407fe3462af5
Publikováno v:
Immunity & Ageing, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background We have previously reported elevated expression of multiple pro-inflammatory markers in the lumbar spinal cord (LSC) of middle-aged male rats compared to young adults suggesting a para-inflammatory state develops in the LSC by mid
Externí odkaz:
https://doaj.org/article/4146de167bb044369d8c004cb3a80dad
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134394 (2015)
Prior studies of aging and neuropathic injury have focused on senescent animals compared to young adults, while changes in middle age, particularly in the dorsal root ganglia (DRG), have remained largely unexplored. 14 neuroimmune mRNA markers, previ
Externí odkaz:
https://doaj.org/article/88265d79a5134520bc818189c7482e6f
Autor:
Huilin Liu, Justas Lauzadis, Kavindu Gunaratna, Erin Sipple, Martin Kaczocha, Michelino Puopolo
Publikováno v:
The Journal of Pain.
Publikováno v:
J Neurosci
A hyperexcitable state and spontaneous activity of nociceptors have been suggested to play a critical role in the development of chronic neuropathic pain following spinal cord injury (SCI). In male rats, we employed the action potential-clamp techniq
Autor:
Seung Min Shin, Justas Lauzadis, Brandon Itson-Zoske, Yongsong Cai, Fan Fan, Gayathri K. Natarajan, Wai-Meng Kwok, Michelino Puopolo, Quinn H. Hogan, Hongwei Yu
Publikováno v:
Pain. 163(12)
Ample data support a prominent role of peripheral T-type calcium channels 3.2 (Ca V 3.2) in generating pain states. Development of primary sensory neuron-specific inhibitors of Ca V 3.2 channels is an opportunity for achieving effective analgesic the
Autor:
Nicole J. Yang, Jörg Isensee, Dylan V. Neel, Andreza U. Quadros, Han-Xiong Bear Zhang, Justas Lauzadis, Sai Man Liu, Stephanie Shiers, Andreea Belu, Shilpa Palan, Sandra Marlin, Jacquie Maignel, Angela Kennedy-Curran, Victoria S. Tong, Mahtab Moayeri, Pascal Röderer, Anja Nitzsche, Mike Lu, Bradley L. Pentelute, Oliver Brüstle, Vineeta Tripathi, Keith A. Foster, Theodore J. Price, R. John Collier, Stephen H. Leppla, Michelino Puopolo, Bruce P. Bean, Thiago M. Cunha, Tim Hucho, Isaac M. Chiu
Publikováno v:
Nat Neurosci
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Bacterial products can act on neurons to alter signaling and function. Here, we find that dorsal root ganglia (DRG) sensory neurons are enriched for ANTXR2, the high-affinity receptor for anthrax toxins. Anthrax toxins are composed of protective anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51535d2a537fb4d96983bf570b33773
https://europepmc.org/articles/PMC9388775/
https://europepmc.org/articles/PMC9388775/
Autor:
Xin Liu, Chilman Bae, Bolong Liu, Yongmei Zhang, Xiangfu Zhou, Donghang Zhang, Cheng Zhou, Adriana DiBua, Livia Schutz, Martin Kaczocha, Michelino Puopolo, Terry P. Yamaguchi, Jin Mo Chung, Shao-Jun Tang
Opioid analgesics are the frontline pain medicine for managing various types of pain. Paradoxically, repeated use of opioid analgesics may cause an exacerbated pain state known as opioid-induced hyperalgesia (OIH). OIH significantly contributes to do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5597449a8c7c1f7b3890e39f899c837
https://doi.org/10.1101/2021.06.19.449129
https://doi.org/10.1101/2021.06.19.449129