Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Micheline Piquette‐Miller"'
Altered Expression of BCRP Impacts Fetal Accumulation of Rosuvastatin in a Rat Model of Preeclampsia
Autor:
Wanying Dai, Micheline Piquette-Miller
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 884 (2024)
Expression of the breast cancer resistance protein (BCRP/ABCG2) transporter is downregulated in placentas from women with preeclampsia (PE) and in an immunological rat model of PE. While many drugs are substrates of this important efflux transporter,
Externí odkaz:
https://doaj.org/article/1a8e69d2455d4e28b1f842cf50cc7c03
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1857 (2023)
Maternal immune activation (MIA) during pregnancy is linked to neurodevelopmental disorders in humans. Similarly, the TLR7 agonist imiquimod alters neurodevelopment in rodents. While the mechanisms underlying MIA-mediated neurodevelopmental changes a
Externí odkaz:
https://doaj.org/article/5f1cafbd976c459c8bf29895ec8d3303
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 3, Pp 580-588 (2020)
Pre‐eclampsia (PE) is an obstetric complication associated with elevated levels of fms‐like tyrosine kinase 1 (sFlt‐1) and dysregulated trophoblast differentiation. However, limited information exists on the expression and regulation of placent
Externí odkaz:
https://doaj.org/article/62e46cb3e0794dd783aa4b42cb2c7225
Autor:
Valerio Taggi, Mario Riera Romo, Micheline Piquette-Miller, Henriette E. Meyer zu Schwabedissen, Sibylle Neuhoff
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1376 (2022)
Drug transporters play an important role in the maintenance of chemical balance and homeostasis in different tissues. In addition to their physiological functions, they are crucial for the absorption, distribution, and elimination of many clinically
Externí odkaz:
https://doaj.org/article/8e5927691ab84cd2b3734e36f2b1c64d
Autor:
Yen Ting Shen, Rashi Asthana, Casper Peeters, Christine Allen, Carlo DeAngelis, Micheline Piquette-Miller
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 23, Iss 1 (2020)
Purpose: Bioluminescent imaging (BLI) is a versatile technique that offers non-invasive and real-time monitoring of tumor development in preclinical cancer research. However, the technique may be limited by several factors that can lead to misinterpr
Externí odkaz:
https://doaj.org/article/d9ffaad4d70a4d16b3750988e380aecf
Autor:
Miles J. Luke, Nina Krupetsky, Helen Liu, Clara Korenvain, Natalie Crown, Sameera Toenjes, Beth A. Sproule, Micheline Piquette-Miller, Lisa M. Guirguis, Lisa M. McCarthy
Publikováno v:
Pharmacy, Vol 9, Iss 4, p 201 (2021)
Research exploring the integration of pharmacogenomics (PGx) testing by pharmacists into their primary care practices (including community pharmacies) has focused on the “external” factors that impact practice implementation. In this study, addit
Externí odkaz:
https://doaj.org/article/f3d52e021b9b4376b87b1be0a83ea03f
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 881 (2021)
Activated T helper 17 (Th-17) cytokines play a role in the pathophysiology of autoimmune and infectious diseases. While these diseases affect many women of childbearing age, little is known about the effect of these cytokines on placental transporter
Externí odkaz:
https://doaj.org/article/f4fb71ced86347b291b28c4b866a7ba5
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 21, Iss 1s (2018)
Interleukin (IL)-6 decreases hepatic expression of numerous transporters. Although IL-6 signaling occurs through STAT3, the extent of the involvement of the STAT3 signaling pathway has not been elucidated. PURPOSE: Our objective was to investigate wh
Externí odkaz:
https://doaj.org/article/cc785b10b1304c6bbceb249aed9f599e
Publikováno v:
Pharmacy, Vol 8, Iss 2, p 55 (2020)
A continuing professional development (CPD) program for pharmacists practicing in community and team-based primary care settings was developed and evaluated using Moore’s framework for the assessment of continuing medical education. The program had
Externí odkaz:
https://doaj.org/article/c7063885531c409c947a7df9a8a0af27
Publikováno v:
Pharmaceutics, Vol 11, Iss 12, p 624 (2019)
Inflammation impacts the expression and function of drug transporters at term-gestation; however, the impact of inflammation on the expression of drug transporters at mid-gestation is largely unknown. Since renal drug transporters play a key role in
Externí odkaz:
https://doaj.org/article/2ba77e2c23fe4f34b2d20c4df46dd975