Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Micheline Giphart-Gassler"'
Autor:
Fernando P.G. Silva, Inês Almeida, Bruno Morolli, Geeske Brouwer-Mandema, Hans Wessels, Rolf Vossen, Harry Vrieling, Erik W.A. Marijt, Peter J.M. Valk, Hanneke C. Kluin-Nelemans, Wolfgang R. Sperr, Wolf-Dieter Ludwig, Micheline Giphart-Gassler
Publikováno v:
Haematologica, Vol 94, Iss 11 (2009)
Background Minimally differentiated acute myeloid leukemia is heterogeneous in karyotype and is defined by immature morphological and molecular characteristics. This originally French-American-British classification is still used in the new World Hea
Externí odkaz:
https://doaj.org/article/b4f0e98bd3934f588cd782920fc4e9de
Autor:
Fernando P.G. Silva, Alexandra Lind, Geeske Brouwer-Mandema, Peter J.M. Valk, Micheline Giphart-Gassler
Publikováno v:
Haematologica, Vol 92, Iss 8 (2007)
Of 52 AML-M0 patients studied, 16 presented a RUNX1 mutation (30.8 %) and 8 carried a trisomy 13 (15 %). We found a strong correlation between trisomy 13 and RUNX1 mutations, i.e, 7 out of 8 cases with trisomy 13 carried a mutation in RUNX1 (87.5 %,
Externí odkaz:
https://doaj.org/article/c7aa874c4db548c1a0405a1bd7a387ae
Autor:
J Peter Svensson, Lukas J A Stalpers, Rebecca E E Esveldt-van Lange, Nicolaas A P Franken, Jaap Haveman, Binie Klein, Ingela Turesson, Harry Vrieling, Micheline Giphart-Gassler
Publikováno v:
PLoS Medicine, Vol 3, Iss 10, p e422 (2006)
BackgroundRadiation is an effective anti-cancer therapy but leads to severe late radiation toxicity in 5%-10% of patients. Assuming that genetic susceptibility impacts this risk, we hypothesized that the cellular response of normal tissue to X-rays c
Externí odkaz:
https://doaj.org/article/d32c69526bc34532b1133fcd15a5f9c8
Autor:
Caro M. Meijers, Leon H.F. Mullenders, Harry Vrieling, Wil A. M. Loenen, Maaike P.G. Vreeswijk, Albert A. van Zeeland, Micheline Giphart-Gassler
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 663:7-14
Irradiation of cells with UVC light induces two types of mutagenic DNA photoproducts, i.e. cyclobutane pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4PP). To investigate the relationship between the frequency of UV-induced
Autor:
Inês Almeida, Geeske Brouwer-Mandema, Harry Vrieling, Micheline Giphart-Gassler, Peter J. M. Valk, Hans W. Wessels, Wolf-Dieter Ludwig, Wolfgang R. Sperr, Hanneke C. Kluin-Nelemans, Fernando P.G. Silva, Erik W.A. Marijt, Rolf H. A. M. Vossen, Bruno Morolli
Publikováno v:
Haematologica, 94(11), 1546-1554. Ferrata Storti Foundation
Haematologica-the Hematology Journal, 94(11), 1546-1554. FERRATA STORTI FOUNDATION
Haematologica-the Hematology Journal, 94(11), 1546-1554. FERRATA STORTI FOUNDATION
BackgroundMinimally differentiated acute myeloid leukemia is heterogeneous in karyotype and is defined by immature morphological and molecular characteristics. This originally French-American-British classification is still used in the new World Heal
Autor:
Antonella Zagaria, B Klein, Bruno Morolli, Clelia Tiziana Storlazzi, Harry Vrieling, Micheline Giphart-Gassler, Luciana Impera, Hanneke C. Kluin-Nelemans, F P G Silva
Publikováno v:
Leukemia. 22:1639-1643
ETV6 (ETS translocation-variant gene 6, located on chromosome 12p), also known as TEL, encodes a transcription repressor belonging to the E26 transforming specific (ETS) family of DNA-binding proteins. ETV6 is known as a proto-oncogene involved in tr
Autor:
Jan Polman, Willem G.E.J. Schoonen, Harry Vrieling, Micheline Giphart-Gassler, Jacqueline J.C.M. Kruse, J. Peter Svensson, Bob van de Water, G. Jean Horbach, Merei Huigsloot
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 617:58-70
Accumulation of damage in undifferentiated cells may threaten homeostasis and regenerative capacity. Remarkably, p53 has been suggested to be transcriptionally inactive in these cells. To gain insight in the kinetics and interplay of the predominant
Autor:
Ed Schuuring, Micheline Giphart-Gassler, Ekaterina S. Jordanova, Katja Philippo, Sietske A. Riemersma, Philip M. Kluin
Publikováno v:
Genes, Chromosomes and Cancer. 35:38-48
Loss of heterozygosity (LOH) is a major mechanism for inactivation of tumor-suppressor genes and has been observed in various solid tumors and lymphomas, The human leukocyte antigen (HLA) region is located at chromosome band 6p21.3, and loss or alter
Autor:
A.G. De Nooij-van Dalen, V. Van Buuren-van Seggelen, C Saraiva, C Monteiro, Jane Cole, Alan R. Lehmann, Micheline Giphart-Gassler, A.R. Conde, Celia A. May, M. Van der Keur, D. Beare, John A.L. Armour, Luisa A. Marcelino, Emily Capulas, H. Steinsgrimsdottir
Publikováno v:
Teratogenesis, Carcinogenesis, and Mutagenesis. 20:357-386
We report the results of a collaborative study aimed at developing reliable, direct assays for mutation in human cells. The project used common lymphoblastoid cell lines, both with and without mutagen treatment, as a shared resource to validate the d
Autor:
Micheline Giphart-Gassler, Harry Vrieling, Susan W.P. Wijnhoven, Petra P. H. Van Sloun, Hanneke Kool, Albert A. van Zeeland
Publikováno v:
Environmental and Molecular Mutagenesis. 34:84-89
During the development of cancer a series of specific genetic alterations have to occur in a stepwise fashion to transform a normal somatic cell into a malignant tumor cell. These genetic changes can be roughly divided in two groups: mutations in pro