Výsledky vyhledávání - "Michele Y. Ono"

Fragile X Mental Retardation 1 (FMR1) Intron 1 Methylation in Blood Predicts Verbal Cognitive Impairment in Female Carriers of Expanded FMR1 Alleles: Evidence from a Pilot Study

Autor: David Francis, David E. Godler, Danuta Z. Loesch, David J. Amor, Glynda J. Kinsella, John L. Hopper, Elsdon Storey, Michele Y. Ono, Freya Gehling, Yoshimi Inaba, Howard R. Slater, Randi J Hagerman, Quang M. Bui

Publikováno v: Clinical Chemistry. 58:590-598

BACKGROUND Cognitive status in females with mutations in the FMR1 (fragile X mental retardation 1) gene is highly variable. A biomarker would be of value for predicting which individuals were liable to develop cognitive impairment and could benefit f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc538c4356a6e1d8054e71b9b1fe6277
https://doi.org/10.1373/clinchem.2011.177626

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Secondary medical diagnosis in fragile X syndrome with and without autism spectrum disorder

Autor: Susan W. Harris, Nicole Tartaglia, Catalina García-Nonell, Eugenia Rigau Ratera, Michele Y. Ono, Flora Tassone, David R Hessl, Emily Marvin, Randi J Hagerman

Publikováno v: American Journal of Medical Genetics Part A. :1911-1916

This study examined whether secondary medical diagnoses that affect CNS function (i.e., seizures, malformations, or genetic disorders), are more likely to occur in individuals with fragile X syndrome (FXS) and autism spectrum disorder (FXS + ASD) or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbee3bc13712aa23384464d075dd525
https://doi.org/10.1002/ajmg.a.32290

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The Prader-Willi Phenotype of Fragile X Syndrome

Autor: Stephen Nowicki, Randi J Hagerman, Michele Y. Ono, Jessica A Ferranti, Beth L. Goodlin-Jones, Flora Tassone, Marie Francoise Croquette

Publikováno v: Journal of Developmental & Behavioral Pediatrics. 28:133-138

The Prader-Willi phenotype (PWP) of fragile X syndrome (FXS) is associated with obesity and hyperphagia similar to Prader-Willi syndrome (PWS), but without cytogenetic or methylation abnormalities at 15q11-13. Thirteen cases of PWP and FXS are report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a5bf054d73ac63b0b9b00a43334b85
https://doi.org/10.1097/01.dbp.0000267563.18952.c9

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Recent advances in fragile X: a model for autism and neurodegeneration

Autor: Paul J. Hagerman, Randi J Hagerman, Michele Y. Ono

Publikováno v: Current Opinion in Psychiatry. 18:490-496

Purpose of reviewThis review will describe recent developments in the neurobiology of fragile X syndrome (FXS), the association between FXS and autism, and involvement in premutation carriers.Recent findingsMetabotropic glutamate receptor 5 (mGluR5)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::911f42c7c8a912f8f03cf73f8c6d1086
https://doi.org/10.1097/01.yco.0000179485.39520.b0

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Dynamics of DNA Condensates at the Solid−Liquid Interface by Atomic Force Microscopy

Autor: Michele Y. Ono and, Eileen M. Spain

Publikováno v: Journal of the American Chemical Society. 121:7330-7334

Real-time dynamics of the interaction of two DNA condensates are imaged with atomic force microscopy under fluid. DNA condensates are formed at the solid−liquid interface of aqueous buffer and chemically modified mica. Atomic force microscopy shows

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b18b4b2a675e10cf277111d4a1d797e2
https://doi.org/10.1021/ja9915697

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Advances in the Treatment of Fragile X Syndrome

Autor: Rebecca Kronk, Carol Delahunty, Jeannie Visootsak, Louise W. Gane, Nicole Tartaglia, David R Hessl, Elizabeth Berry-Kravis, Michele Y. Ono, Walter E. Kaufmann, Jonathan Picker, Ave M. Lachiewicz, Randi J Hagerman, Michael Tranfaglia

The FMR1 mutations can cause a variety of disabilities, including cognitive deficits, attention-deficit/hyperactivity disorder, autism, and other socioemotional problems, in individuals with the full mutation form (fragile X syndrome) and distinct di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d7c82efcbb61fe64ed2938aeef0326
https://europepmc.org/articles/PMC2888470/

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Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes

Autor: David J. Riese, Sarah M. Slavik, Stephanie L. Coffing, Jennifer L. Vanderpoel, Andrew B. Morris, John K. Lim, Michele Y. Ono, Scott E. Taylor, Kitaw Negash, Henry F. VanBrocklin, Darren L. Hom, Stephen M. Hanrahan

Publikováno v: Journal of medicinal chemistry. 48(23)

The epidermal growth factor receptor (EGFR), a long-standing drug development target, is also a desirable target for imaging. Sixteen dialkoxyquinazoline analogues, suitable for labeling with positron-emitting isotopes, have been synthesized and eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139965c01f7b52370def249f382361ee
https://pubmed.ncbi.nlm.nih.gov/16279804

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