Výsledky vyhledávání - "Michele Vasaturo"

The anti-tumor diterpene oridonin is a direct inhibitor of Nucleolin in cancer cells

Autor: Roberta Cotugno, Fabrizio Dal Piaz, Nunziatina De Tommasi, Michele Vasaturo, Lorenzo Fiengo, Claudio Vinegoni

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports

The bioactive plant diterpene oridonin displays important pharmacological activities and is widely used in traditional Chinese medicine; however, its molecular mechanism of action is still incompletely described. In vitro and in vivo data have demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6356a122ab3c0fdf48d26684f3dcd7b7
http://link.springer.com/article/10.1038/s41598-018-35088-x

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N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil Targeting FBXW7 Tumor Suppressor

Autor: Fabrizio Dal Piaz, Cristina Pagano, Michele Vasaturo, C. Laezza, Maurizio Bifulco, Bruno Marcello Fusco, Maria Proto, Chiara Piscopo, Donatella Fiore, Patrizia Gazzerro

Publikováno v: Cancers, Vol 11, Iss 10, p 1456 (2019)
Cancers
Volume 11
Issue 10
Cancers (Basel) 11 (2019). doi:10.3390/cancers11101456
info:cnr-pdr/source/autori:Fiore D.; Piscopo C.; Proto M.C.; Vasaturo M.; Piaz F.D.; Fusco B.M.; Pagano C.; Laezza C.; Bifulco M.; Gazzerro P./titolo:N6-isopentenyladenosine inhibits colorectal cancer and improves sensitivity to 5-fluorouracil-targeting FBXW7 tumor suppressor/doi:10.3390%2Fcancers11101456/rivista:Cancers (Basel)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:11

N6-isopentenyladenosine has been shown to exert potent in vitro antitumor activity on different human cancers, including colorectal cancer. Although some potential biochemical targets have been identified, its precise mechanism of action remains uncl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ffc77da31b05f457db09de0a6604ee
https://www.mdpi.com/2072-6694/11/10/1456

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Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach

Autor: Ciro Milite, Maria C. Vaccaro, Nicola Malafronte, Maria Giovanna Chini, Maria J. Gualtieri, Sabrina Castellano, Antonietta Leone, Giuseppe Bifulco, Antonio Vassallo, Michele Vasaturo, Fabrizio Dal Piaz, Nunziatina De Tommasi

Publikováno v: Chemistry - A European Journal. 22:13236-13250

The identification of inhibitors of Hsp90 is currently a primary goal in the development of more effective drugs for the treatment of various types of multidrug resistant malignancies. In an attempt to identify new small molecules modulating the acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ccacb70750d7e00660af0b4831e7a7
https://doi.org/10.1002/chem.201602242

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Identification and mechanism of action analysis of the new PARP-1 inhibitor 2″-hydroxygenkwanol A

Autor: Nunziatina De Tommasi, Fabrizio Dal Piaz, Maria Giovanna Chini, Michele Vasaturo, Piera Ferro, Alessandra Tosco, Giuseppe Bifulco, Giovanni Forte, Antonio Vassallo

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1850:1806-1814

Background Poly(ADP-ribose) polymerase 1 (PARP-1) activity has been implicated in the pathogenesis of numerous diseases as cancer, inflammation, diabetes and neurodegenerative disorders, therefore the research for new PARP-1 inhibitors is still an ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfff04887e76588eae5155c2cf046abf
https://doi.org/10.1016/j.bbagen.2015.05.014

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A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability

Autor: Vittorio Colantuoni, Carmen Cerchia, Pamela Ziccardi, Nunziatina De Tommasi, Fabrizio Dal Piaz, Angelo Lupo, Lina Sabatino, Ettore Novellino, Maurizio Bruno, Michele Vasaturo, Lorenzo Fiengo, Antonio Lavecchia

Publikováno v: Scientific Reports

Proteomics based approaches are emerging as useful tools to identify the targets of bioactive compounds and elucidate their molecular mechanisms of action. Here, we applied a chemical proteomic strategy to identify the peroxisome proliferator-activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22dd5f5843f35fd0a0da11bc2eca7780

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Biomolecular proteomics discloses ATP synthase as the main target of the natural glycoside deglucoruscin

Autor: Raffaele Riccio, Agostino Casapullo, Michele Vasaturo, Carmen Festa, Maria Chiara Monti, Federica del Gaudio, Simona De Marino, Matteo Mozzicafreddo

Extracts of Ruscus aculeatus are a rich source of bioactive steroidal glycosides, such as ruscogenins which are reported to act against chronic venous disorders. Nowadays, several preparations of its roots, commonly used in traditional medicine, are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc20ca51c9ccde93d8f95502e3ebdb84
http://hdl.handle.net/11588/643126

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Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells

Autor: Michele Vasaturo, Luca Parente, Ada Popolo, Valentina Bizzarro, Raffaella Belvedere, Antonello Petrella, Fabrizio Dal Piaz, Paola Picardi

Publikováno v: BMC Cancer

Background: Annexin A1 (ANXA1), a 37 kDa multifunctional protein, is over-expressed in tissues from patients of pancreatic carcinoma (PC) where the protein seems to be associated with malignant transformation and poor prognosis. Methods: The expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfcea4a9b74bbf7c2e1edfd1ee3f744
http://europepmc.org/articles/PMC4301448

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Bioactive Limonoids from the Leaves of Azaridachta indica (Neem)

Autor: Antonio Vassallo, Nicola Malafronte, Maria J. Gualtieri, Michele Vasaturo, Alessandra Braca, Nunziatina De Tommasi, Fabrizio Dal Piaz, Roberta Cotugno

Eight new limonoids (1–8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1–9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77296506c156588fc30eceb5220ebc1e
http://hdl.handle.net/11386/4356258

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