Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michele Tomanelli"'
Publikováno v:
Life, Vol 13, Iss 12, p 2284 (2023)
Intracranial primary tumors (IPTs) are aggressive forms of malignancies that cause high mortality in both humans and domestic animals. Meningiomas are frequent adult IPTs in humans, dogs, and cats, and both benign and malignant forms cause a decrease
Externí odkaz:
https://doaj.org/article/e4f2fbee54d2473a9efffacb7098a94a
Autor:
Elisa Bonaldi, Michele Tomanelli, Alice Iezzi, Marina Chiara Garassino, Elisa Caiola, Marika Colombo, Edoardo Micotti, Massimo Broggini, Arianna Scagliotti, Lucia Minoli, Mirko Marabese, Eugenio Scanziani, Federica Guffanti
Publikováno v:
Journal of Thoracic Oncology. 15:360-370
Introduction Serine/threonine kinase 11 (LKB1/STK11) is one of the most mutated genes in NSCLC accounting for approximately one-third of cases and its activity is impaired in approximately half of KRAS-mutated NSCLC. At present, these patients cannot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8b984982a4286fb1c3afcb5482d835
https://doi.org/10.1016/j.jtho.2019.10.009
https://doi.org/10.1016/j.jtho.2019.10.009
Autor:
Roberta Frapolli, Michele Tomanelli, Alice Iezzi, Massimo Broggini, Rossana Valerio, Marina Chiara Garassino, Elisa Caiola, Mirko Marabese
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Scientific Reports
Scientific Reports
Non-Small-Cell Lung Cancer (NSCLC) is a poorly chemosensitive tumor and targeted therapies are only used for about 15% of patients where a specific driving and druggable lesion is observed (EGFR, ALK, ROS). KRAS is one of the most frequently mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfbb2e98a310bed0fe4276d71534ff9
https://doi.org/10.1038/s41598-017-18900-y
https://doi.org/10.1038/s41598-017-18900-y
Autor:
Alice Iezzi, Arianna Scagliotti, Mirko Marabese, Michele Tomanelli, Elisa Bonaldi, Massimo Broggini, Elisa Caiola
Publikováno v:
ESMO Open. 3:A34-A35
Introduction Lung Cancer is the first cause of cancer-related death in the world. The alterations in KRAS oncogene are very frequent (25%), but, unfortunately, this protein is at present undruggable. KRAS mutations determine over-activation of import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2425d5d98da793131ee2fa046af97b76
https://doi.org/10.1136/esmoopen-2018-eacr25.80
https://doi.org/10.1136/esmoopen-2018-eacr25.80