Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Michele Tinti"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Although genome-wide polycistronic transcription places major emphasis on post-transcriptional controls in trypanosomatids, messenger RNA cis-regulatory untranslated regions (UTRs) have remained largely uncharacterised. Here, we describe a g
Externí odkaz:
https://doaj.org/article/33cb6962a551462faf5258253779e7b0
Autor:
Joana R. C. Faria, Michele Tinti, Catarina A. Marques, Martin Zoltner, Harunori Yoshikawa, Mark C. Field, David Horn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract UPF1-like helicases play roles in telomeric heterochromatin formation and X-chromosome inactivation, and also in monogenic variant surface glycoprotein (VSG) expression via VSG exclusion-factor-2 (VEX2), a UPF1-related protein in the African
Externí odkaz:
https://doaj.org/article/16ff35d784f44ce5b0d4ec6740ef38bd
Autor:
Lindsay B. Tulloch, Sandra Carvalho, Marta Lima, Richard J. Wall, Michele Tinti, Erika G. Pinto, Lorna MacLean, Susan Wyllie
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTVisceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. New therapeutic options with diverse mechanisms of actions (MoAs) are required to consolidate progress toward control o
Externí odkaz:
https://doaj.org/article/7bb16e5a50ee43d6b0b2d50b417e7077
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Progression of the canonical eukaryotic cell cycle is tightly regulated. While the cell cycle control of flagellated protozoa Trypanosoma brucei shares conserved features with other eukaryotes certain cell cycle checkpoints are absent. Here, Marques
Externí odkaz:
https://doaj.org/article/8280850909f14bf194bd49b8a55c126f
Autor:
Michele Tinti, Michael A. J. Ferguson
Publikováno v:
Wellcome Open Research, Vol 7 (2023)
Background: Trypanosoma brucei is a protozoan parasite and etiological agent of human and animal African trypanosomiasis. It has a complex life cycle, but the most studied cellular types are the in vitro cultivated bloodstream- and procyclic-forms. T
Externí odkaz:
https://doaj.org/article/d9432d36f34d4fdd978bd057bb8a4aa9
Publikováno v:
mSphere, Vol 7, Iss 2 (2022)
ABSTRACT Variant surface glycoproteins (VSGs) coat parasitic African trypanosomes and underpin antigenic variation and immune evasion. These VSGs are superabundant virulence factors that are subject to posttranscriptional gene expression controls med
Externí odkaz:
https://doaj.org/article/8a3fa1d9e73441a59fe9f92cf3253f6e
Autor:
Michele Tinti, Michael A. J. Ferguson
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: Trypanosoma brucei is a protozoan parasite and etiological agent of human and animal African trypanosomiasis. It has a complex life cycle, but the most studied cellular types are the in vitro cultivated bloodstream- and procyclic-forms. T
Externí odkaz:
https://doaj.org/article/6e9d8d7f925f40f49d38e3fa2c5b8aa1
Autor:
Michael A. J. Ferguson, Michele Tinti
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: Trypanosoma brucei is a protozoan parasite and the etiological agent of human and animal African trypanosomiasis. The organism cycles between its mammalian host and tsetse vector. The host-dwelling bloodstream form of the parasite is cove
Externí odkaz:
https://doaj.org/article/319a8b9ccd024aa88506f5b187e30f6f
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: The contrasting physiological environments of Trypanosoma brucei procyclic (insect vector) and bloodstream (mammalian host) forms necessitates deployment of different molecular processes and, therefore, changes in protein expression. Tran
Externí odkaz:
https://doaj.org/article/dfb93ae1a7b6469f840065f83ca8143f
Autor:
Carla Gilabert Carbajo, Lucy J Cornell, Youssef Madbouly, Zhihao Lai, Phillip A Yates, Michele Tinti, Calvin Tiengwe
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009696 (2021)
Iron is an essential regulatory signal for virulence factors in many pathogens. Mammals and bloodstream form (BSF) Trypanosoma brucei obtain iron by receptor-mediated endocytosis of transferrin bound to receptors (TfR) but the mechanisms by which T.
Externí odkaz:
https://doaj.org/article/77a1b755c58441838b870af7cd58b3a6