Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michele Simonetti"'
Autor:
Ning Zhang, Luuk Harbers, Michele Simonetti, Constantin Diekmann, Quentin Verron, Enrico Berrino, Sara E. Bellomo, Gabriel M. C. Longo, Michael Ratz, Niklas Schultz, Firas Tarish, Peng Su, Bo Han, Wanzhong Wang, Sofia Onorato, Dora Grassini, Roberto Ballarino, Silvia Giordano, Qifeng Yang, Anna Sapino, Jonas Frisén, Kanar Alkass, Henrik Druid, Vassilis Roukos, Thomas Helleday, Caterina Marchiò, Magda Bienko, Nicola Crosetto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Somatic copy number alterations (SCNAs) are pervasive in advanced human cancers, but their prevalence and spatial distribution in early-stage, localized tumors and their surrounding normal tissues are poorly characterized. Here, we perform m
Externí odkaz:
https://doaj.org/article/a7bc352b5e9d473f9b3b201fba7c47d9
Autor:
Marcin Nicoś, PhD, Luuk Harbers, MSc, Enrico Patrucco, PhD, Maximilian Kramer-Drauberg, PhD, Xiaolu Zhang, PhD, Claudia Voena, PhD, Anna Kowalczyk, MD, PhD, Aleksandra Bożyk, PhD, Rafał Pęksa, MD, PhD, Bożena Jarosz, MD, PhD, Justyna Szumiło, MD, Michele Simonetti, PhD, Monika Żuk, PhD, Bartosz Wasąg, MD, Katarzyna Reszka, PhD, Renata Duchnowska, MD, Janusz Milanowski, MD, Roberto Chiarle, MD, Magda Bienko, PhD, Paweł Krawczyk, MD, Jacek Jassem, MD, Chiara Ambrogio, PhD, Nicola Crosetto, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 3, Iss 12, Pp 100435- (2022)
Introduction: Brain metastases (BM) severely affect the prognosis and quality of life of patients with NSCLC. Recently, molecularly targeted agents were found to have promising activity against BM in patients with NSCLC whose primary tumors carry “
Externí odkaz:
https://doaj.org/article/93978b32039848998a35af7844ee33cf
Autor:
Ioannis Zerdes, Michele Simonetti, Alexios Matikas, Luuk Harbers, Balazs Acs, Ceren Boyaci, Ning Zhang, Dimitrios Salgkamis, Susanne Agartz, Pablo Moreno-Ruiz, Yalai Bai, David L. Rimm, Johan Hartman, Artur Mezheyeuski, Jonas Bergh, Nicola Crosetto, Theodoros Foukakis
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Emerging data indicate that genomic alterations can shape immune cell composition in early breast cancer. However, there is a need for complementary imaging and sequencing methods for the quantitative assessment of combined somatic copy numb
Externí odkaz:
https://doaj.org/article/3346ad4f61b5411594a62c963ed56bb4
Autor:
Michele Simonetti, Ning Zhang, Luuk Harbers, Maria Grazia Milia, Silvia Brossa, Thi Thu Huong Nguyen, Francesco Cerutti, Enrico Berrino, Anna Sapino, Magda Bienko, Antonino Sottile, Valeria Ghisetti, Nicola Crosetto
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Genomic surveillance of SARS-CoV-2 is crucial to monitor the spread of variants of concern. A new sequencing method enables cost-effective SARS-CoV-2 genomic surveillance at scale and is easily adaptable to other viruses.
Externí odkaz:
https://doaj.org/article/59ac650297524e1a915ee584a53ec570
Autor:
Xiaolu Zhang, Silvano Garnerone, Michele Simonetti, Luuk Harbers, Marcin Nicoś, Reza Mirzazadeh, Tiziana Venesio, Anna Sapino, Johan Hartman, Caterina Marchiò, Magda Bienko, Nicola Crosetto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Genomics DNA library preparation from formalin-fixed paraffin-embedded tissues is challenging. Here the authors describe CUTseq that uses restriction enzymes and in vitro amplification to barcode samples for reduced representation genome sequencing.
Externí odkaz:
https://doaj.org/article/5bd13737717a4dc7914df1406868bf3e
Autor:
Sabrina Cipriani, Barbara Renga, Claudio D'Amore, Michele Simonetti, Antonio Angelo De Tursi, Adriana Carino, Maria Chiara Monti, Valentina Sepe, Angela Zampella, Stefano Fiorucci
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0129866 (2015)
In cholestatic syndromes, body accumulation of bile acids is thought to cause itching. However, the mechanisms supporting this effect remain elusive. Recently, GPBAR1 (TGR5) a G-protein coupled receptor has been shown to mediate itching caused by int
Externí odkaz:
https://doaj.org/article/785cebc253384ea9ac82397275fdeef3
Autor:
Barbara Renga, Sabrina Cipriani, Adriana Carino, Michele Simonetti, Angela Zampella, Stefano Fiorucci
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141082 (2015)
GPBAR1 is a bile acids activated receptor expressed in entero-hepatic tissues. In the liver expression of GPBAR1 is restricted to sinusoidal and Kuppfer cells. In the systemic circulation vasodilation caused by GPBAR1 agonists is abrogated by inhibit
Externí odkaz:
https://doaj.org/article/8778f54e2b0e4e4788a507dc0b58d008
Autor:
Ning Zhang, Michele Simonetti, Luuk Harbers, Thomas Helleday, Vassilis Roukos, Caterina Marchio, Magda Bienko, Nicola Crosetto
Chromosomal instability and copy number alterations (CNAs) are pervasive in human cancers. However, the exact timing and mechanism of CNA formation during carcinogenesis remain poorly understood. Here, we describe scCUTseq, an agile and robust workfl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23da6786adef7fa5c5dcf94ce5b7470f
https://doi.org/10.21203/rs.3.pex-1602/v1
https://doi.org/10.21203/rs.3.pex-1602/v1
Autor:
Jonas Bergh, Theodoros Foukakis, Pablo Moreno-Ruiz, Johan Hartman, Balazs Acs, Michele Simonetti, Susanne Agartz, Ning Zhang, Luuk Harbers, Dimitrios Salgkamis, David L. Rimm, Yalai Bai, Nicola Crosetto, Alexios Matikas, Artur Mezheyeuski, Ioannis Zerdes, Ceren Boyaci
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-11 (2021)
NPJ Breast Cancer
NPJ Breast Cancer
Emerging data indicate that genomic alterations can shape immune cell composition in early breast cancer. However, there is a need for complementary imaging and sequencing methods for the quantitative assessment of combined somatic copy number altera
Autor:
Jonas Bergh, Markella Zacharouli, Ioannis Zerdes, Johan Hartman, Luuk Harbers, Michele Simonetti, Susanne Agartz, Ning Zhang, Dimitrios Salgkamis, Alexios Matikas, Theodoros Foukakis, Nicola Crosetto, Pablo Moreno-Ruiz, Artur Mezheyeuski
Publikováno v:
Cancer Research. 81:PS18-27
Background: Given the emerging role of immune-related biomarkers in breast cancer (BC), little is known about specific immune cell composition patterns and genomic alterations and how these could interact in early BC setting. The aim of this proof-of