Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michele Rovini"'
Autor:
Vincenzo Calderone, Antonio Giordani, Gianluca Giorgi, Angela Di Capua, Andrea Cappelli, Germano Giuliani, Maurizio Anzini, Paola Patrignani, Carla Ghelardini, Luisa Chiasserini, Giovanna Poce, Lara Testai, Melania Dovizio, Lorenzo Di Cesare Mannelli, Antonietta Rossi, Mariangela Biava, Alma Martelli, V. Benetti, Salvatore Valenti, Salvatore Vomero, Paola Anzellotti, Simone Brogi, Alessandro Sega, Simona Pace, Michele Rovini, Lidia Sautebin
Publikováno v:
Journal of medicinal chemistry. 56(8)
A series of 3-substituted 1,5-diarylpyrroles bearing a nitrooxyalkyl side chain linked to different spacers were designed. New classes of pyrrole-derived nitrooxyalkyl inverse esters, carbonates, and ethers (7-10) as COX-2 selective inhibitors and NO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8898a3e667bc129de1046241e6562d94
https://pubmed.ncbi.nlm.nih.gov/23534442
https://pubmed.ncbi.nlm.nih.gov/23534442
Autor:
Antonietta Rossi, P. Patrignani, Carla Ghelardini, S. Alfonso, Paola Anzellotti, Gianluca Giorgi, Antonio Giordani, Di Cesare Mannelli L, Claudio Battilocchio, Giovanna Poce, Mariangela Biava, Salvatore Valenti, Annalisa Bruno, Michele Rovini, Papa G, Giulio Cesare Porretta, L. Sautebin, Anzini M, Calderone, Alma Martelli, Lara Testai
Publikováno v:
Journal of medicinal chemistry. 54(22)
The design of compounds that are able to inhibit cyclooxygenase (COX) and to release nitric oxide (NO) should give rise to drugs endowed with an overall safer profile for the gastrointestinal and cardiovascular systems. Herein we report a new class o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c531ce5629b29c5cdd1fc043bd22a2
https://pubmed.ncbi.nlm.nih.gov/21992176
https://pubmed.ncbi.nlm.nih.gov/21992176
Autor:
L. Sautebin, Maurizio Botta, Fabrizio Manetti, Michele Rovini, G. C. Porretta, Antonio Giordani, Maurizio Anzini, Claudio Battilocchio, S. Tacconelli, Antonietta Rossi, P. Patrignani, Francesco Makovec, Giovanna Poce, Nicoletta Galeotti, Carlo Pergola, Mariangela Biava, Carla Ghelardini, Paola Anzellotti, Andrea Cappelli
The development of the coxib family has represented a stimulating approach in the treatment of inflammatory disorders, such as arthritis, and for the management of acute pains, in relation to the well-known traditional Non-Steroidal Anti-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5453c2789c7b12517804164731397978
http://hdl.handle.net/2158/586712
http://hdl.handle.net/2158/586712
Autor:
Antonio Giordano, Melinda Maddalena, Alessandra Rossi, Maurizio Anzini, Giuseppina Sorda, Anna Maria Aloisi, Paolo Fiorenzani, Michele Rovini, Barbara Danielli, Ilaria Ceccarelli, Andrea Cappelli, Valentina Tomei
Publikováno v:
Molecular Pain, Vol 6, Iss 1, p 69 (2010)
Molecular Pain
Molecular Pain
Background: The steroid hormone testosterone has been found to be greatly reduced by opioids in different experimental and clinical conditions. The purpose of this study on male rats was to determine the effects of a single injection of morphine (5 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b598fa0b993b7387ba7c0a236b6dc957
http://hdl.handle.net/11365/2505
http://hdl.handle.net/11365/2505
Autor:
Antonio Giordani, Monica Norcini, Salvatore Vomero, Fabrizio Manetti, Maurizio Anzini, Antonietta Rossi, P. Patrignani, Carla Ghelardini, Francesco Makovec, Maurizio Botta, Paola Anzellotti, Andrea Cappelli, Michele Rovini, Carlo Pergola, L. Sautebin, Mariangela Biava
A series of substituted 1,5-diarylpyrrole-3-alkoxyethyl ethers (6, 7, and 8) has been synthesized with the aim to assess if in the previously reported 1,5-diarylpyrrole derivatives (5) the replacement of the acetic ester moiety with an alkoxyethyl gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c0e27c7dde0b4ca5344d0c1e7f1ff9
http://hdl.handle.net/11365/21130
http://hdl.handle.net/11365/21130
Autor:
Simona Merlini, Michele Rovini, Antonella Tabucchi, Dario Cattaneo, Maurizio Anzini, Filippo Carlucci
Mycophenolate mofetil (MMF) is a widely used drug for the maintenance of immunosuppressive therapy in renal-transplant recipients. MMF is rapidly metabolized in vivo to mycophenolic acid (MPA), a reversible, noncompetitive inhibitor of inosine monoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1121bb957dda7fecd8048a5286ee7d
http://hdl.handle.net/11365/8733
http://hdl.handle.net/11365/8733
Autor:
Francesco Makovec, Giovanna Poce, E. Vivoli, Andrea Cappelli, Michele Rovini, G. C. Porretta, Carla Ghelardini, Carlo Pergola, Maurizio Botta, Mariangela Biava, Antonietta Rossi, P. Patrignani, Stefano Forli, Fabrizio Manetti, L. Sautebin, Paola Anzellotti, Sibilla Supino, Maurizio Anzini
The important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates. We previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a481b4a465484431c938352f99f8bd1
http://hdl.handle.net/11588/111689
http://hdl.handle.net/11588/111689
Autor:
Gennaro Pescitelli, Salvatore Vomero, Maurizio Anzini, Andrea Cappelli, Lorenzo Di Bari, Michele Rovini, Piero Salvadori
Three racemic esters based on the 1,5-diarylpyrrole structure, which proved to be highly selective COX-2 inhibitors endowed with an appreciable anti-inflammatory activity in some animal models, were subjected to chiral resolution. Their absolute conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be33002bcf94529ad642ae60732df513
http://hdl.handle.net/11365/3494
http://hdl.handle.net/11365/3494
Autor:
Maurizio Anzini, Angela Di Capua, Salvatore Valenti, Simone Brogi, Michele Rovini, Germano Giuliani, Andrea Cappelli, Salvatore Vomero, Luisa Chiasserini, Alessandro Sega, Giovanna Poce, Gianluca Giorgi, Vincenzo Calderone, Alma Martelli, Lara Testai, Lidia Sautebin, Antonietta Rossi, Simona Pace, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Veronica Benetti, Antonio Giordani, Paola Anzellotti, Melania Dovizio, Paola Patrignani, Mariangela Biava
Publikováno v:
Journal of Medicinal Chemistry. 56:4821-4821
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b723f648f8c68c484b502e4a3cf68e09
https://doi.org/10.1021/jm400748x
https://doi.org/10.1021/jm400748x
Autor:
Mauro Galeazzi, Andrea Cappelli, Giulia Collodel, T. Laura, Tommaso Serchi, Maurizio Anzini, Antonella Fioravanti, Elena Moretti, Michele Rovini, Salvatore Vomero
Publikováno v:
Osteoarthritis and Cartilage. 16:S84
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2439d59d3e9428903efba45dac9fe4
https://doi.org/10.1016/s1063-4584(08)60213-7
https://doi.org/10.1016/s1063-4584(08)60213-7