Výsledky vyhledávání - "Michele R. Stabile"

Modulation of Esterase and Amidase Activity of Subtilisin Bacillus lentus by Chemical Modification of Cysteine Mutants

Autor: J. Bryan Jones, and Michele R. Stabile, Erika Plettner, Grace Desantis

Publikováno v: Journal of the American Chemical Society. 121:4977-4981

For synthetic applications of proteases, such as for peptide coupling, a combination of high esterase and low amidase activities is required. While achieving such specificity has been a long-standing goal, the decreases in amidase activity achieved t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01e814a742ebb5372313f7a2525b5e06
https://doi.org/10.1021/ja9902266

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Probing the specificity of the S1 binding site of M222 mutants of subtilisin B. lentus with boronic acid inhibitors

Autor: W. George Lai, J. Bryan Jones, Thomas P. Graycar, Grace Desantis, Richard R. Bott, Colin Mitchinson, Marvin Gold, Michele R. Stabile, Chung-Cheng Liu

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2501-2506

Specificity differences between the S1-pockets of subtilisin B. lentus (SBL), and its M222C/S mutants have been explored with boronic acid inhibitors. Similar binding trends were noted, with 2,4-dichlorophenylboronic acid being the best overall inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cd1e41c7539f4e021c1296837b6b9af
https://doi.org/10.1016/0960-894x(96)00466-0

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Chemoenzymatic synthesis of the morphine skeleton via radical cyclization and a C10C11 closure

Autor: Stephen P. Fearnley, Gabor Butora, Andrew G. Gum, Tomas Hudlicky, Michele R. Stabile, Khalil A. Abboud

Publikováno v: Tetrahedron Letters. 37:8155-8158

A short synthesis of a morphinan skeleton has been accomplished. The key steps involve enzymatic dihydroxylation of β-bromoethyl benzene, vinyl and aryl radical cyclizations, and Friedel-Crafts closure of an aziridinium ion or an acid-catalyzed clos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a0e3bc5833a1166759cc84614b675a9
https://doi.org/10.1016/0040-4039(96)01867-9

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New chiral synthon from bromoethylbenzene: Absolute stereochemistry of a biooxidation metabolite

Autor: Meredith L. Meisels, Michele R. Stabile, Tomas Hudlicky

Publikováno v: Tetrahedron: Asymmetry. 6:537-542

(2-Bromoethyl)benzene was subjected to biooxidation with whole cells of Pseudomonas putida 39/D to yield (1 S , 2 R ) 3-(2-bromoethyl)-cyclohexa-3,5-diene-1,2-diol 1 with an optical purity of 96%.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b0a376cfb5f87bbcd19970cac05ec8e
https://doi.org/10.1016/0957-4166(95)00037-p

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Oxidation of 2-(2-bromoethyl)bromobenzene with toluene dioxygenase: Isolation and identification of new chiral synthons

Autor: A. G. Gum, Andrew J. Thorpe, Stephen P. Fearnley, Gabor Butora, Tomas Hudlicky, Matthew R. Ellis, Meredith L. Meisels, Michele R. Stabile

Publikováno v: Chirality. 7:556-559

2(2-Bromoethyl)bromobenzene was subjected to microbial oxidation by the whole cells of Pseudomonas putida 39/D and JM109(pDTG601) yielding (3R,4S)-2-(2-bromoethyl)-bromocyclohexa-1,5-diene-3,4-diol. © 1995 Wiley-Liss, Inc.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5ff47809f829a44707fe8bb2c3c3563
https://doi.org/10.1002/chir.530070710

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Intramolecular Diels–Alder reactions of the furan diene (IMDAF); rapid construction of highly functionalised isoquinoline skeletons

Autor: A. G. Gum, Gabor Butora, Tomas Hudlicky, P. J. Persichini, Joseph S. Merola, Michele R. Stabile, Stephen P. Fearnley

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :2393-2398

Intramolecular Diels–Alder reaction of substituted furans has been investigated as a prelude to focused application to the synthesis of isoquinoline alkaloids. Several conditions have been investigated for the model compound 6 containing both unact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a05aed638fe13071af603730f9b1a759
https://doi.org/10.1039/p19950002393

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