Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Michele Pietrafesa"'
Autor:
Guido Giordano, Pietro Parcesepe, Giuseppina Bruno, Annamaria Piscazzi, Vincenzo Lizzi, Andrea Remo, Massimo Pancione, Mario Rosario D’Andrea, Elena De Santis, Luigi Coppola, Michele Pietrafesa, Alberto Fersini, Antonio Ambrosi, Matteo Landriscina
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7717 (2021)
Target-oriented agents improve metastatic colorectal cancer (mCRC) survival in combination with chemotherapy. However, the majority of patients experience disease progression after first-line treatment and are eligible for second-line approaches. In
Externí odkaz:
https://doaj.org/article/a585bcde8c7c4acc928cd01d67a5f4ba
Autor:
Giacomo Lettini, Valentina Condelli, Michele Pietrafesa, Fabiana Crispo, Pietro Zoppoli, Francesca Maddalena, Ilaria Laurenzana, Alessandro Sgambato, Franca Esposito, Matteo Landriscina
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7526 (2020)
Wnt/β-Catenin signaling is involved in embryonic development, regeneration, and cellular differentiation and is responsible for cancer stemness maintenance. The HSP90 molecular chaperone TRAP1 is upregulated in 60–70% of human colorectal carcinoma
Externí odkaz:
https://doaj.org/article/19034249c8914e1f8ced42be4cbc536e
Autor:
Fabiana Crispo, Michele Pietrafesa, Valentina Condelli, Francesca Maddalena, Giuseppina Bruno, Annamaria Piscazzi, Alessandro Sgambato, Franca Esposito, Matteo Landriscina
Publikováno v:
Molecules, Vol 25, Iss 16, p 3754 (2020)
Cholangiocarcinoma is a primary malignancy of the biliary tract characterized by late and unspecific symptoms, unfavorable prognosis, and few treatment options. The advent of next-generation sequencing has revealed potential targetable or actionable
Externí odkaz:
https://doaj.org/article/e75a858fb11e46fcaccf73d283e63b70
Autor:
Michele Pietrafesa, Francesca Maddalena, Luciana Possidente, Valentina Condelli, Pietro Zoppoli, Valeria Li Bergolis, Maria Grazia Rodriquenz, Michele Aieta, Giulia Vita, Franca Esposito, Matteo Landriscina
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 145 (2019)
Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1) is a heat shock protein 90 (HSP90) molecular chaperone overexpressed in 60−70% human colorectal carcinomas (CRCs) and the co-upregulation of TRAP1 and associated 6-related proteins identif
Externí odkaz:
https://doaj.org/article/c49bfe29f584480eb204861552a4b757
Autor:
Valentina Condelli, Fabiana Crispo, Michele Pietrafesa, Giacomo Lettini, Danilo Swann Matassa, Franca Esposito, Matteo Landriscina, Francesca Maddalena
Publikováno v:
Cells, Vol 8, Iss 6, p 532 (2019)
Heat shock protein 90 (HSP90) molecular chaperones are a family of ubiquitous proteins participating in several cellular functions through the regulation of folding and/or assembly of large multiprotein complexes and client proteins. Thus, HSP90s cha
Externí odkaz:
https://doaj.org/article/5fac772dc3f845699d1e379d3306fdc6
Autor:
Lorenza Sisinni, Michele Pietrafesa, Silvia Lepore, Francesca Maddalena, Valentina Condelli, Franca Esposito, Matteo Landriscina
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 4, p 857 (2019)
The unfolded protein response (UPR) is a stress response activated by the accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its uncontrolled activation is mechanistically responsible for several human p
Externí odkaz:
https://doaj.org/article/3c7f4a63a9ee4ae1934744ba1fb1cb39
Autor:
Annamaria, Piscazzi, Valentina, Condelli, Fabiana, Crispo, Anna Rita Daniela, Coda, Giovanni, Calice, Giuseppina, Bruno, Santina, Venuto, Daniele, Tibullo, Guido, Giordano, Michele, Pietrafesa, Arcangelo, Liso, Matteo, Landriscina
Publikováno v:
Oncology Letters. 23
Insulin-like growth factor binding protein 6 (IGFBP6) is a secreted protein with a controversial role in human malignancies, being downregulated in most types of human cancer, but upregulated in selected tumors. Ovarian cancer (OC) is a human maligna
Autor:
Giuseppina Bruno, Valeria Li Bergolis, Annamaria Piscazzi, Fabiana Crispo, Valentina Condelli, Pietro Zoppoli, Francesca Maddalena, Michele Pietrafesa, Guido Giordano, Danilo Matassa, Franca Esposito, Matteo Landriscina
Publikováno v:
International journal of oncology. 60(6)
Metabolic rewiring fuels rapid cancer cell proliferation by promoting adjustments in energetic resources, and increasing glucose uptake and its conversion into lactate, even in the presence of oxygen. Furthermore, solid tumors often contain hypoxic a
Autor:
Annamaria Piscazzi, Giacomo Lettini, Vittorio Simeon, Pietro Zoppoli, Valentina Condelli, Michele Pietrafesa, Maria Iole Natalicchio, Silvia Lepore, Lorenza Sisinni, Matteo Landriscina, Maria Carmela Pedicillo
Publikováno v:
International Journal of Medical Sciences
Background: HPV-positive oral squamous cell carcinomas (OSCCs) are specific biological and clinical entities, characterized by a more favorable prognosis compared to HPV-negative OSCCs and occurring generally in non-smoking and non-drinking younger i
Autor:
Alberto Fersini, Guido Giordano, Pietro Parcesepe, Andrea Remo, Luigi Michele Coppola, Vincenzo Lizzi, Matteo Landriscina, Mario D'Andrea, Giuseppina Bruno, Elena De Santis, Antonio Ambrosi, Annamaria Piscazzi, Massimo Pancione, Michele Pietrafesa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7717, p 7717 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Target-oriented agents improve metastatic colorectal cancer (mCRC) survival in combination with chemotherapy. However, the majority of patients experience disease progression after first-line treatment and are eligible for second-line approaches. In