Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Michele Pelosi"'
1
Akademický článek
Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations
Autor: Michele Pelosi, Eric Testet, Soazig Le Lay, Isabelle Dugail, Xiaoyun Tang, Guillaume Mabilleau, Yamina Hamel, Marine Madrange, Thomas Blanc, Thierry Odent, Todd P.W. McMullen, Marco Alfò, David N. Brindley, Pascale de Lonlay
Publikováno v: Journal of Lipid Research, Vol 58, Iss 12, Pp 2348-2364 (2017)
Lipin-1 is a Mg2+-dependent phosphatidic acid phosphatase (PAP) that in mice is necessary for normal glycerolipid biosynthesis, controlling adipocyte metabolism, and adipogenic differentiation. Mice carrying inactivating mutations in the Lpin1 gene d
Externí odkaz: https://doaj.org/article/cf817ac8be29467abb21d280db7df091
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2
Akademický článek
A thermolabile aldolase A mutant causes fever-induced recurrent rhabdomyolysis without hemolytic anemia.
Autor: Asmaa Mamoune, Michel Bahuau, Yamina Hamel, Valérie Serre, Michele Pelosi, Florence Habarou, Marie-Ange Nguyen Morel, Bertrand Boisson, Sabrina Vergnaud, Mai Thao Viou, Luc Nonnenmacher, Monique Piraud, Patrick Nusbaum, Joseph Vamecq, Norma Romero, Chris Ottolenghi, Jean-Laurent Casanova, Pascale de Lonlay
Publikováno v: PLoS Genetics, Vol 10, Iss 11, p e1004711 (2014)
Aldolase A deficiency has been reported as a rare cause of hemolytic anemia occasionally associated with myopathy. We identified a deleterious homozygous mutation in the ALDOA gene in 3 siblings with episodic rhabdomyolysis without hemolytic anemia.
Externí odkaz: https://doaj.org/article/3473475ac66b4e78b0e843eda9d685cc
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4
Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations
Autor: Pascale de Lonlay, Michele Pelosi, Soazig Le Lay, Yamina Hamel, Todd P. W. McMullen, David N. Brindley, Guillaume Mabilleau, Xiaoyun Tang, Marine Madrange, Thomas Blanc, Eric Testet, Marco Alfò, T. Odent, Isabelle Dugail
Publikováno v: Journal of Lipid Research
Journal of Lipid Research, 2017, 58 (12), pp.2348-2364. ⟨10.1194/jlr.P075440⟩
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2017, 58 (12), pp.2348-2364. ⟨10.1194/jlr.P075440⟩
Journal of Lipid Research, Vol 58, Iss 12, Pp 2348-2364 (2017)
International audience; Lipin-1 is a Mg2+-dependent phosphatidic acid phosphatase (PAP) that in mice is necessary for normal glycerolipid biosynthesis, controlling adipocytes metabolism and adipogenic differentiation. Mice carrying inactivating mutat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c71a927a596d765d23cb8fcfa7ba2e
https://doi.org/10.1194/jlr.P075440
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5
Parathyroid hormone-related protein is induced by hypoxia and promotes expression of the differentiated phenotype of human articular chondrocytes
Autor: Christopher L. Murphy, Stefano Lazzarano, Michele Pelosi, Brendan L. Thoms
Publikováno v: Clinical Science. 125:461-470
PTHrP (parathyroid hormone-related protein) is crucial for normal cartilage development and long bone growth and acts to delay chondrocyte hypertrophy and terminal differentiation in the growth plate. After growth plate closure adult HACs (human arti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05aee617945e4155bd38d9eec2275b7
https://doi.org/10.1042/cs20120610
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6
LRP‐1‐mediated endocytosis regulates extracellular activity of ADAMTS‐5 in articular cartilage
Autor: Christopher L. Murphy, Hideaki Nagase, Linda Troeberg, Kazuhiro Yamamoto, Dudley K. Strickland, Michele Pelosi, Simone D. Scilabra
Publikováno v: The FASEB Journal. 27:511-521
Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial event in the development of osteoarthritis (OA). Adamalysin-like metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is a major aggrecan-degrading enz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2082a6477a73ae65e23f32e4d76f4f
https://doi.org/10.1096/fj.12-216671
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7
ROCK2 and Its Alternatively Spliced Isoform ROCK2m Positively Control the Maturation of the Myogenic Program
Autor: Michele Pelosi, Antonio Musarò, Nadia Rosenthal, Shuh Narumiya, Viviana Caputo, Sabrina Prudente, Valeria Berno, Luciano Cianetti, Shin W Kang, Bianca M. Zani, Francesco Marampon, Emerald Perlas
Publikováno v: Molecular and Cellular Biology. 27:6163-6176
Signal transduction cascades involving Rho-associated kinases (ROCK), the serine/threonine kinases downstream effectors of Rho, have been implicated in the regulation of diverse cellular functions including cytoskeletal organization, cell size contro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d589d0ea0bbea59b3be3d4ff5f1c2bda
https://doi.org/10.1128/mcb.01735-06
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8
A Thermolabile Aldolase A Mutant Causes Fever-Induced Recurrent Rhabdomyolysis without Hemolytic Anemia
Autor: Valérie Serre, Monique Piraud, Norma B. Romero, Florence Habarou, Asmaa Mamoune, Jean-Laurent Casanova, Michele Pelosi, Pascale de Lonlay, Mai Thao Viou, Patrick Nusbaum, Luc Nonnenmacher, Marie-Ange Nguyen Morel, Yamina Hamel, Chris Ottolenghi, Bertrand Boisson, Michel Bahuau, Sabrina Vergnaud, Joseph Vamecq
Publikováno v: PLoS Genetics
PLoS Genetics, 2014, 10 (11), pp.e1004711. ⟨10.1371/journal.pgen.1004711⟩
PLoS Genetics, Public Library of Science, 2014, 10 (11), pp.e1004711. ⟨10.1371/journal.pgen.1004711⟩
PLoS Genetics, Vol 10, Iss 11, p e1004711 (2014)
PLoS Genetics, Public Library of Science, 2014, 10 (11), pp.e1004711. <10.1371/journal.pgen.1004711>
PLoS Genetics, Public Library of Science, 2014, 10 (11), pp.e1004711. 〈10.1371/journal.pgen.1004711〉
International audience; Aldolase A deficiency has been reported as a rare cause of hemolytic anemia occasionally associated with myopathy. We identified a deleterious homozygous mutation in the ALDOA gene in 3 siblings with episodic rhabdomyolysis wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5c8db83b83ef06965344b833450846
https://hal.sorbonne-universite.fr/hal-01342663
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9
IL-6 impairs myogenic differentiation by downmodulation of p90RSK/eEF2 and mTOR/p70S6K axes, without affecting AKT activity
Autor: Laura Barberi, Manuela De Rossi, Antonio Musarò, Michele Pelosi
Publikováno v: BioMed Research International
BioMed Research International, Hindawi Publishing Corporation, 2014, 2014, pp.206026. ⟨10.1155/2014/206026⟩
BioMed Research International, Vol 2014 (2014)
IL-6 is a multifaceted pleiotropic cytokine, which is produced by a variety of cell types and targets different cells and tissues. In physiological conditions, IL-6 can be locally and transiently produced by skeletal muscle and plays an important rol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b58498a0e9d50e46e6d30313722538e
https://hal-riip.archives-ouvertes.fr/pasteur-01182462
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10
A potential role for protein tyrosine kinase p56(lck) in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness
Autor: Michele Pelosi, Joost P. M. van Meerwijk, Alain Cantagrel, Donna Strahan, Paola Romagnoli
Publikováno v: International immunology. 13(3)
Rheumatoid arthritis (RA) synovial fluid (SF)-T lymphocytes appear relatively inactive in situ and respond only weakly to diverse stimuli ex vivo. To characterize the molecular defects underlying this hyporesponsiveness we analyzed the expression lev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e74e0dc3713b4cb3603a3ad0422d1aa
https://pubmed.ncbi.nlm.nih.gov/11222499
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