Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michele P. Marron"'
Autor:
Alexandra E. Grier, Michele P. Marron, David V. Serreze, Marijke Niens, Dale L. Greiner, Thomas W.H. Kay
Publikováno v:
Diabetes
OBJECTIVE Type 1 diabetes can be inhibited in standard NOD mice by autoantigen-specific immunotherapy targeting pathogenic CD8+ T-cells. NOD.β2mnull.HHD mice expressing human HLA-A2.1 but lacking murine major histocompatibility complex class I molec
Autor:
Jason C. Baker, Irene Jarchum, Toshiyuki Takaki, David V. Serreze, Teresa P. DiLorenzo, Michele P. Marron, Tatsuya Yamada
Publikováno v:
Diabetes. 56:2551-2560
OBJECTIVE—CD8+ T-cells specific for islet antigens are essential for the development of type 1 diabetes in the NOD mouse model of the disease. Such T-cells can also be detected in the blood of type 1 diabetic patients, suggesting their importance i
Autor:
Massimo Trucco, David V. Serreze, Toshiyuki Takaki, Clayton E. Mathews, Michele P. Marron, Stephen T. Guttmann, Rita Bottino, Teresa P. DiLorenzo
Publikováno v:
The Journal of Immunology. 176:3257-3265
In both humans and NOD mice, particular MHC genes are primary contributors to development of the autoreactive CD4+ and CD8+ T cell responses against pancreatic β cells that cause type 1 diabetes (T1D). Association studies have suggested, but not pro
Publikováno v:
Proceedings of the National Academy of Sciences. 99:13753-13758
Particular major histocompatibility complex (MHC) class II alleles clearly contribute to T cell-mediated autoimmune type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice. However, studies in NOD mice indicate MHC class I-restricted T
Autor:
Michele P. Marron, David V. Serreze, Robyn Maree Slattery, Brett Charlton, Arno Müllbacher, Ellis A. Johnson, Emma E. Hamilton-Williams
Publikováno v:
Proceedings of the National Academy of Sciences. 98:11533-11538
Type 1 diabetes in both humans and nonobese diabetic (NOD) mice results from T-cell-mediated autoimmune destruction of insulin-producing pancreatic β cells. Linkage studies have shown that type 1 diabetes in NOD mice is a polygenic disease involving
Autor:
Pablo A. Silveira, Yoshitaka Yoshimura, David V. Serreze, Ellis A. Johnson, Teresa P. DiLorenzo, Harold D. Chapman, Sebastian Joyce, Stanley G. Nathenson, Robert T. Graser, Michele P. Marron
Publikováno v:
Diabetes. 50:1992-2000
A broad repertoire of pancreatic β-cell autoreactive T-cells normally contributes to the development of type 1 diabetes in NOD mice. However, it has been unknown if a large reduction in the precursor pool from which autoreactive T-cells are drawn wo
Autor:
Adina Zeidler, Jin-Xiong She, Mark C. K. Yang, Jean Francois Bach, James J. Yang, Sarah Eckenrode, Diane Hopkins, Michele P. Marron, Yongsoo Park, Henri Jean Garchon, Chaim O. Jacob, Leslie J. Raffel, Jerome I. Rotter, Manuel Serrano-Ríos, María Teresa Martínez Larrad
Publikováno v:
Diabetes. 49:492-499
Polymorphic markers within the CTLA4 gene on chromosome 2q33 have been shown to be associated with type 1 diabetes. Therefore, a gene responsible for the disease (IDDM12) most likely lies within a region of
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes
Autor:
Strominger Jl, Kent Sc, Clive Wasserfall, Mark A. Atkinson, David A. Hafler, Andrew Muir, Jin-Xiong She, Michele P. Marron, Neuberg Ds, Reimsneider S, Tamir M. Ellis, S B Wilson
Publikováno v:
Proceedings of the National Academy of Sciences. 96:8116-8119
Markedly elevated levels of serum IL-4 were reported previously in 50% of a small group of type 1 diabetes nonprogessors. To determine the patterns of expression for this phenotype, a larger cohort of 58 families containing type 1 diabetic patients w
Autor:
Bobbilynn Hawkins-Lee, Michele P. Marron, Yi-Qun Huang, Qing-Guo Ruan, Jing-Da Shi, Cong-Yi Wang, Jin-Xiong She, Bernardo Ochoa
Publikováno v:
American Journal of Medical Genetics. 84:454-459
The urofacial (Ochoa) syndrome (UFS) is a rare autosomal recessive disorder characterized by abnormal facial expression and urinary abnormalities. Previously, we mapped the gene to a genomic interval of approximately 1 cM on chromosome region 10q23-2
Autor:
John C. Detter, Qing Guo Ruan, Yi Qun Huang, Jing Da Shi, Michele P. Marron, Cong-Yi Wang, Jin-Xiong She
Publikováno v:
Autoimmunity. 31:47-53
We have recently cloned the murine autoimmune regulator (Aire) gene, the homologue of human AIRE responsible for the autoimmune polyglandular syndrome type 1 (APS1) or autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED). Here, we