Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Michele Mishto"'
Publikováno v:
eLife, Vol 13 (2024)
Mass cytometry is a cutting-edge high-dimensional technology for profiling marker expression at the single-cell level, advancing clinical research in immune monitoring. Nevertheless, the vast data generated by cytometry by time-of-flight (CyTOF) pose
Externí odkaz:
https://doaj.org/article/cb08c1cbe40549cca694acaf7a99b8df
Autor:
Wai Tuck Soh, Hanna P. Roetschke, John A. Cormican, Bei Fang Teo, Nyet Cheng Chiam, Monika Raabe, Ralf Pflanz, Fabian Henneberg, Stefan Becker, Ashwin Chari, Haiyan Liu, Henning Urlaub, Juliane Liepe, Michele Mishto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract If and how proteasomes catalyze not only peptide hydrolysis but also peptide splicing is an open question that has divided the scientific community. The debate has so far been based on immunopeptidomics, in vitro digestions of synthetic poly
Externí odkaz:
https://doaj.org/article/b17003d64f9544af818720977eafb74a
Autor:
Hanna P. Roetschke, Guillermo Rodriguez-Hernandez, John A. Cormican, Xiaoping Yang, Steven Lynham, Michele Mishto, Juliane Liepe
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-22 (2023)
Abstract Noncanonical epitopes presented by Human Leucocyte Antigen class I (HLA-I) complexes to CD8+ T cells attracted the spotlight in the research of novel immunotherapies against cancer, infection and autoimmunity. Proteasomes, which are the main
Externí odkaz:
https://doaj.org/article/7581743a49874334bcd875238d583deb
Autor:
Michele Mishto, Guillermo Rodriguez-Hernandez, Jacques Neefjes, Henning Urlaub, Juliane Liepe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/ed00d8bd3da842e7b734fbc4cc606cba
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Increasing evidence suggests that post-translational peptide splicing can play a role in the immune response under pathological conditions. This seems to be particularly relevant in Type 1 Diabetes (T1D) since post-translationally spliced epitopes de
Externí odkaz:
https://doaj.org/article/cefcd8e1e47d4904b649b381de8dbafc
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The human immune system relies on the capability of CD8+ T cells to patrol body cells, spot infected cells and eliminate them. This cytotoxic response is supposed to be limited to infected cells to avoid killing of healthy cells. To enable this, CD8+
Externí odkaz:
https://doaj.org/article/a9f5ed74576c4d55bc64b7830e9a96e4
Autor:
Anouk C.M. Platteel, Juliane Liepe, Kathrin Textoris-Taube, Christin Keller, Petra Henklein, Hanna H. Schalkwijk, Rebeca Cardoso, Peter M. Kloetzel, Michele Mishto, Alice J.A.M. Sijts
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1242-1253 (2017)
Summary: Proteasome-catalyzed peptide splicing (PCPS) generates peptides that are presented by MHC class I molecules, but because their identification is challenging, the immunological relevance of spliced peptides remains unclear. Here, we developed
Externí odkaz:
https://doaj.org/article/dbbb84c5c1774707b8e9c342d573f020
Autor:
Michele Mishto, Artem Mansurkhodzhaev, Ge Ying, Aruna Bitra, Robert A. Cordfunke, Sarah Henze, Debdas Paul, John Sidney, Henning Urlaub, Jacques Neefjes, Alessandro Sette, Dirk M. Zajonc, Juliane Liepe
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Targeting CD8+ T cells to recurrent tumor-specific mutations can profoundly contribute to cancer treatment. Some of these mutations are potential tumor antigens although they can be displayed by non-spliced epitopes only in a few patients, because of
Externí odkaz:
https://doaj.org/article/bd2035f8513243a1a896fac804a15745
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Efficient and safe induction of CD8+ T cell responses is a desired characteristic of vaccines against intracellular pathogens. To achieve this, a new generation of safe vaccines is being developed accommodating single, dominant antigens of pathogens
Externí odkaz:
https://doaj.org/article/7a7c6b9f343945dabbf6755815e736ca
Autor:
Juliane Liepe, Herman-Georg Holzhütter, Peter M. Kloetzel, Michael P. H. Stumpf, Michele Mishto
Publikováno v:
Biomolecules, Vol 4, Iss 2, Pp 585-599 (2014)
Proteasomes are key proteases involved in a variety of processes ranging from the clearance of damaged proteins to the presentation of antigens to CD8+ T-lymphocytes. Which cleavage sites are used within the target proteins and how fast these protein
Externí odkaz:
https://doaj.org/article/3b995493abdf4de18c6ee277be88eb18