Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michele Matheis"'
Autor:
Todd C. Henninger, Dennis J. Hlasta, Michael P. Wachter, Dennis C. Argentieri, Michele A. Weidner-Wells, Michele Matheis, David M. Ritchie, Christine M. Boggs, Stephanie A. Fraga-Spano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4307-4311
A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8 induced elastase release from neutrophils. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984bc281c15de937c9532b2050d824c4
https://doi.org/10.1016/j.bmcl.2004.05.080
https://doi.org/10.1016/j.bmcl.2004.05.080
Autor:
Druie Cavender, Mingde Xia, Michele Matheis, Meng Pan, Monica Singer, William V. Murray, Demong Duane E, Scott R. Pollack, Michael P. Wachter, Cuifen Hou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6468-6470
The synthesis and structure-activity relationship of a series of 7-azaindole piperidine derivatives are described. SAR studies led to the discovery of the potent CCR2 antagonists displaying IC(50) values in the nanomolar range. The representative com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953f731037971b5faa2d4a3c9a3a0f5a
https://doi.org/10.1016/j.bmcl.2008.10.061
https://doi.org/10.1016/j.bmcl.2008.10.061
Autor:
James Brackley, Monica Singer, Cuifen Hou, Michael P. Wachter, Druie Cavender, Michele Matheis, Mingde Xia, Meng Pan, Scott R. Pollack, Demong Duane E
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3562-3564
The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure-activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC(50) values in the nanomolar or subnanomolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e084a0c77db0c8f8366185d0b2ba1c3
https://doi.org/10.1016/j.bmcl.2008.05.010
https://doi.org/10.1016/j.bmcl.2008.05.010
Autor:
Monica Singer, Ravi Malaviya, Nareshkumar F. Jain, Chrissy Gerchak, Meng Pan, Demong Duane E, Michael P. Wachter, Cuifen Hou, Druie Cavender, Michele Matheis, Gil Olini, Mingde Xia, James Brackley, Scott R. Pollack
Publikováno v:
Journal of medicinal chemistry. 50(23)
A series of substituted dipiperidine compounds have been synthesized and identified as selective CCR2 antagonists. Combining the most favorable substituents led to the discovery of remarkably potent CCR2 antagonists displaying IC50 values in the nano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39488e1d575b9efde2afb68953bba86
https://pubmed.ncbi.nlm.nih.gov/17929797
https://pubmed.ncbi.nlm.nih.gov/17929797
Autor:
Cuifen Hou, Monica Singer, Michele Matheis, Scott R. Pollack, Demong Duane E, Michael P. Wachter, Meng Pan, Druie Cavender, Mingde Xia, Gil Olini, James Brackley
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
A series of phenyl piperidine derivatives possessing potent and selective CCR2 antagonist activity is reported. Structure–activity relationship (SAR) studies have established that incorporation of a second ring system adjacent to the aryl piperidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ce8b33b0398e9a5915e41552b70d89
https://pubmed.ncbi.nlm.nih.gov/17869105
https://pubmed.ncbi.nlm.nih.gov/17869105
Autor:
Druie Cavender, Michele Matheis, Dennis C. Argentieri, Cuifen Hou, Monica Singer, Thomas Kirchner
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 309(2)
To investigate the role of phospholipase C (PLC) in inflammatory processes, we tested 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), a widely used PLC inhibitor, in several in vitro and in vivo assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7e9a77d9e7fd651d59675bbd6d4054
https://pubmed.ncbi.nlm.nih.gov/14730005
https://pubmed.ncbi.nlm.nih.gov/14730005
Autor:
Cuifen, Hou, Thomas, Kirchner, Monica, Singer, Michele, Matheis, Dennis, Argentieri, Druie, Cavender
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; May 2004, Vol. 309 Issue: 2 p697-704, 8p
Autor:
Mingde Xia, Cuifen Hou, Duane E. DeMong, Scott R. Pollack, Meng Pan, James A. Brackley, Nareshkumar Jain, Chrissy Gerchak, Monica Singer, Ravi Malaviya, Michele Matheis, Gil Olini, Druie Cavender, Michael Wachter
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 23, p5561-5563, 3p