Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michele M. P. Lufino"'
Autor:
Fernando Cavalcanti, Elena Gonzalez-Rey, Mario Delgado, Clara P. Falo, Leyre Mestre, Carmen Guaza, Francisco O’Valle, Michele M. P. Lufino, Jordi Xaus, Cristina Mascaró, Serena Lunardi, Natalia Sacilotto, Paola Dessanti, David Rotllant, Xavier Navarro, Mireia Herrando-Grabulosa, Carlos Buesa, Tamara Maes
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1420 (2022)
Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes that regulate the expression of genes involved in the onset and progression of
Externí odkaz:
https://doaj.org/article/df089ff6678843aa91f71f1d603fc7ce
Autor:
Natalia, Sacilotto, Paola, Dessanti, Michele M P, Lufino, Alberto, Ortega, Alejandra, Rodríguez-Gimeno, Jordi, Salas, Tamara, Maes, Carlos, Buesa, Cristina, Mascaró, Robert, Soliva
Publikováno v:
ACS pharmacologytranslational science. 4(6)
Lysine-specific demethylase 1 (LSD1 or KDM1A) is a chromatin modifying enzyme playing a key role in the cell cycle and cell differentiation and proliferation through the demethylation of histones and nonhistone substrates. In addition to its enzymati
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004318 (2014)
Friedreich ataxia (FRDA) and Fragile X syndrome (FXS) are among 40 diseases associated with expansion of repeated sequences (TREDs). Although their molecular pathology is not well understood, formation of repressive chromatin and unusual DNA structur
Externí odkaz:
https://doaj.org/article/59d3b62d01cf4bcfae2f59ce38e7822d
Autor:
Michele M P, Lufino, Pauline A H, Edser, Michael A, Quail, Stephen, Rice, David J, Adams, Richard, Wade-Martins
Publikováno v:
Scientific Reports
Gene dosage plays a critical role in a range of cellular phenotypes, yet most cellular expression systems use heterologous cDNA-based vectors which express proteins well above physiological levels. In contrast, genomic DNA expression vectors generate
Autor:
Michele M P, Lufino, Anna R, Popplestone, Sally A, Cowley, Pauline A H, Edser, William S, James, Richard, Wade-Martins
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 767
Herpes simplex type 1 (HSV-1) amplicon vectors possess a number of features that make them excellent vectors for the delivery of transgenes into stem cells. HSV-1 amplicon vectors are capable of efficiently transducing both dividing and nondividing c