Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michele M. Maxwell"'
Autor:
Allison M. Amore, Michele M. Maxwell, Luisa Quinti, Johnathan Nobles, Vanita Chopra, Elizabeth M. Tomkinson, Aleksey G. Kazantsev, John W. Wizeman, Steven M. Hersch
Publikováno v:
Human Molecular Genetics. 20:3986-3996
Sirtuin 2 (SIRT2) is one of seven known mammalian protein deacetylases homologous to the yeast master lifespan regulator Sir2. In recent years, the sirtuin protein deacetylases have emerged as candidate therapeutic targets for many human diseases, in
Autor:
Guney Boso, Christina Jamieson, Nicholas A. Cacalano, Michele M. Maxwell, Silvia Diaz-Perez, Joseph J. Belanto, Clara E. Magyar, Kasey Topp, Yasemin Yilmaz, Catriona Jamieson
Publikováno v:
Neuromuscular Disorders. 20:111-121
Glucocorticoids are beneficial in many muscular dystrophies but they are ineffective in treating dysferlinopathy, a rare muscular dystrophy caused by loss of dysferlin. We sought to understand the molecular basis for this disparity by studying the ef
Autor:
Jean-Christophe Rochet, Eirene Kontopoulos, Ruben Abagyan, Allison M. Amore, Bradley T. Hyman, Irina Kufareva, Mel B. Feany, Tiago F. Outeiro, Catherine B. Volk, Stephen M. Altmann, Aleksey G. Kazantsev, Anne B. Young, Michele M. Maxwell, Pamela J. McLean, Katherine E. Strathearn
Publikováno v:
Science. 317:516-519
The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued α-s
Autor:
Michele M. Maxwell, Aleksey G. Kazantsev, Michael Y. Sherman, Sabine Engemann, Gillian P. Bates, Donna L. Smith, Deborah E. Russel, David E. Housman, Shetia L. Washington, Anne B. Young, Margo Roark, Xiaoqian Zhang, Erich E. Wanker, J. Lawrence Marsh, Anatoli B. Meriin, Leslie M. Thompson
Publikováno v:
Proceedings of the National Academy of Sciences. 102:892-897
Polyglutamine (polyQ) disorders, including Huntington's disease (HD), are caused by expansion of polyQ-encoding repeats within otherwise unrelated gene products. In polyQ diseases, the pathology and death of affected neurons are associated with the a
Publikováno v:
Journal of Biological Chemistry. 270:25213-25219
Ke 6 gene is a newly identified gene located in the major histocompatibility complex and is a candidate steroid dehydrogenase gene because of structural homology and regulatory similarities with mammalian steroid dehydrogenases. We report here the co
Autor:
David E. Housman, Myra Coufal, Aleksey G. Kazantsev, Michele M. Maxwell, Deborah E. Russel, Anne B. Young, Stephen M. Altmann, Allison M. Amore, Zane R. Hollingsworth
Publikováno v:
Journal of biomolecular screening. 12(3)
CAG-triplet repeat extension, translated into polyglutamines within the coding frame of otherwise unrelated gene products, causes 9 incurable neurodegenerative disorders, including Huntington's disease. Although an expansion in the CAG repeat length
Autor:
Wendy J. Broom, Robert H. Brown, Li-An Yeh, Aleksey G. Kazantsev, Marcie A. Glicksman, Kristen E. Auwarter, Michele M. Maxwell, Deborah E. Russel, Jake Ni
Publikováno v:
Journal of biomolecular screening. 11(7)
Familial amyotrophic lateral sclerosis (ALS) accounts for 10% of all ALS cases; approximately 25% of these cases are due to mutations in the Cu/Zn superoxide dismutase gene (SOD1). To date, 105 different mutations spanning all 5 exons have been ident
Autor:
Bradley T. Hyman, Ruth A. Bodner, Aleksey G. Kazantsev, Stephanie H. Cho, Stephen M. Altmann, Pamela J. McLean, Tiago F. Outeiro, David E. Housman, Michele M. Maxwell, Anne B. Young
Misfolded proteins accumulate in many neurodegenerative diseases, including huntingtin in Huntington’s disease and α-synuclein in Parkinson’s disease. The disease-causing proteins can take various conformations and are prone to aggregate and for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a282b17bb95579a766095283fb6ded27
https://europepmc.org/articles/PMC1449678/
https://europepmc.org/articles/PMC1449678/
Autor:
Andrey Muryshev, Jonathan H. Fox, Francine N. Norflus, Ruben Abagyan, Elisa Fossale, Marcy E. MacDonald, Steven M. Hersch, Michele M. Maxwell, Anne B. Young, Aleksey G. Kazantsev, Stephen M. Altmann
Publikováno v:
Chemistrybiology. 13(7)
SummaryPoly (ADP-ribose) polymerase (PARP1) is a nuclear protein that, when overactivated by oxidative stress-induced DNA damage, ADP ribosylates target proteins leading to dramatic cellular ATP depletion. We have discovered a biologically active sma
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(9)
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disorder resulting from selective death of motor neurons in the brain and spinal cord. In ≈25% of familial ALS cases, the disease is caused by dominantly acting point